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Cytochrome P-450 CYP1A2

Known as: Demethylase, Caffeine, P-450 LM4, Cytochrome, Cytochrome P-450d 
A cytochrome P450 enzyme subtype that has specificity for relatively planar heteroaromatic small molecules, such as CAFFEINE and ACETAMINOPHEN.
National Institutes of Health

Related topics

Related topics

27 relations
AromataseCYP19A1 protein, humanCYP1A2 geneCYP2C18 protein, human

Broader (4)

Aryl Hydrocarbon HydroxylasesCytochrome P450OxidoreductaseXenobiotic Monooxygenases

Narrower (2)

CYP1A2 protein, humanCyp1a2 protein, rat

Papers overview

Semantic Scholar uses AI to extract papers important to this topic.
2007
2007
Association between allelic polymorphisms of metabolizing enzymes (CYP 1A1, CYP 1A2, CYP 2E1, mEH) and occurrence of colorectal cancer in Hungary.
BACKGROUND Genetic polymorphisms of metabolizing enzymes may affect the risk of cancer formation in humans. Since the diet can… 
Highly Cited
2000
Highly Cited
2000
3D-QSAR methods on the basis of ligand–receptor complexes. Application of COMBINE and GRID/GOLPE methodologies to a series of CYP1A2 ligands
Many heterocyclic amines (HCA) present in cooked food exert a genotoxic activity when they are metabolised (N-oxidated) by the… 
Highly Cited
1996
Highly Cited
1996
Validation of precision-cut liver slices in dynamic organ culture as an in vitro model for studying CYP1A1 and CYP1A2 induction.
The utilization of precision-cut liver slices in dynamic organ culture as an in vitro model was validated by comparing the… 
Highly Cited
1994
Highly Cited
1994
Dose-response relationships in mice following subchronic exposure to 2,3,7,8-tetrachlorodibenzo-p-dioxin: CYP1A1, CYP1A2, estrogen receptor, and protein tyrosine phosphorylation.
The dose-response relationships for different endpoints in different tissues were compared in response to 2,3,7,8… 
1988
1988
Induction of the rat hepatic microsomal mixed-function oxidases by 3 imidazole-containing antifungal agents: selectivity for the cytochrome P-450IIB and P-450III families of cytochromes P-450.
Highly Cited
1987
Highly Cited
1987
Spectral and kinetic studies of the interaction of imidazole anti-fungal agents with microsomal cytochromes P-450.
1. The imidazole antifungal agents, ketoconazole, miconazole and clotrimazole have been shown to be potent inhibitors of the… 
1986
1986
Mechanisms of lipid peroxidation dependent upon cytochrome P-450 LM2.
A mechanism of lipid peroxidation dependent on the oxidase activity of cytochrome P-450 LM2 in reconstituted membrane vesicles… 
1984
1984
The peroxidatic function of liver microsomal cytochrome P-450: comparison of hydrogen peroxide and NADPH-catalysed N-demethylation reactions.
Fifteen different secondary and tertiary methyl amines have been examined as substrates for the cytochromes P-450 of rat-liver… 
Highly Cited
1982
Highly Cited
1982
Multiplicity strain differences, and topology of phenobarbital-induced cytochromes P-450 in rat liver microsomes.
The multiplicity of phenobarbital-induced cytochromes P-450 in live microsomes from male rats was investigated by using two… 
1982
1982
Different patterns of benzo[a]pyrene metabolism of purified cytochromes P-450 from methylcholanthrene, beta-naphthoflavone and phenobarbital treated rats.
An improved high-pressure liquid chromatography system was used to analyze the amount of benzo[a]pyrene metabolites formed in… 
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