Cytochrome P-450 CYP1A2

Known as: Demethylase, Caffeine, P-450 LM4, Cytochrome, Cytochrome P-450d 
A cytochrome P450 enzyme subtype that has specificity for relatively planar heteroaromatic small molecules, such as CAFFEINE and ACETAMINOPHEN.
National Institutes of Health

Topic mentions per year

Topic mentions per year

1970-2017
0204019702017

Papers overview

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Highly Cited
2008
Highly Cited
2008
OBJECTIVES The purpose of this study was to examine the effect of cigarette smoking on the platelet response to clopidogrel… (More)
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2008
2008
The inhibition activity of 36 flavonoids against CYP1A2 was determined by our previously developed in vitro method. The… (More)
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2004
2004
This study was aimed at identifying the isoform(s) of human liver cytochrome P450 (CYP) involved in the hepatic biotransformation… (More)
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Highly Cited
2001
Highly Cited
2001
The steady-state kinetics and specific activity of 2-, 4-, and 16alpha-hydroxylation of 17beta-estradiol (E(2)) were evaluated… (More)
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2001
2001
trans-Resveratrol (3,5,4'-trihydroxy-trans-stilbene) has been reported to confer chemoprotection against 7,12-dimethylbenz[a… (More)
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1999
1999
Azelastine, an antiallergy and antiasthmatic drug, has been reported to be mainly N-demethylated to desmethylazelastine in humans… (More)
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Highly Cited
1998
Highly Cited
1998
Acetaminophen (APAP) hepatotoxicity is due to its biotransformation to a reactive metabolite, N-acetyl-p-benzoquinone imine… (More)
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1995
1995
Endothelium is a single-cell layer lining blood vessels and constituting capillaries and could be a primary site of chemical… (More)
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1994
1994
Oxidative metabolic pathways of propranolol consist of naphthalene ring-hydroxylations (at the 4-, 5-, and 7-positions) and side… (More)
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Highly Cited
1992
Highly Cited
1992
Six human cytochrome P450s expressed in HepG2 cells using vaccinia virus cDNA-directed expression, were used to study the… (More)
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