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Cytochrome P-450 CYP1A2

Known as: Demethylase, Caffeine, P-450 LM4, Cytochrome, Cytochrome P-450d 
A cytochrome P450 enzyme subtype that has specificity for relatively planar heteroaromatic small molecules, such as CAFFEINE and ACETAMINOPHEN.
National Institutes of Health

Related topics

Related topics

27 relations
AromataseCYP19A1 protein, humanCYP1A2 geneCYP2C18 protein, human

Broader (4)

Aryl Hydrocarbon HydroxylasesCytochrome P450OxidoreductaseXenobiotic Monooxygenases

Narrower (2)

CYP1A2 protein, humanCyp1a2 protein, rat

Papers overview

Semantic Scholar uses AI to extract papers important to this topic.
2008
2008
Inhibition of CYP1A2-mediated drug metabolism in vitro and in humans : With special emphasis on rofecoxib and other NSAIDs
2007
2007
CYP 2 A 13 Metabolizes the Substrates of Human CYP 1 A 2 , Phenacetin , and Theophylline
  • 2007
  • Corpus ID: 29499160
Human cytochrome CYP2A13 shows overlapping substrate specificity with CYP2A6, catalyzing the metabolism of coumarin, nicotine… 
2005
2005
Modulation of UDP-Glucuronosyltransferase 2 B 7 Function by Cytochrome P 450 s in Vitro : Differential Effects of CYP 1 A 2 , CYP 2 C 9 and CYP 3 A 4
Shuso TAKEDA, Yuji ISHII, Peter I. MACKENZIE, Kiyoshi NAGATA, Yasushi YAMAZOE, Kazuta OGURI, and Hideyuki YAMADA* a Graduate… 
2002
2002
OXIDATION OF THE FLAVONOIDS GALANGIN AND KAEMPFERIDE BY HUMAN LIVER MICROSOMES AND CYP 1 A 1 , CYP 1 A 2 , AND CYP 2
  • 2002
  • Corpus ID: 15576129
There is very limited information on cytochrome P450 (P450)-mediated oxidative metabolism of dietary flavonoids in humans. In… 
2001
2001
IMPORTANCE OF AMINE p K a AND DISTRIBUTION COEFFICIENT IN THE METABOLISM OF FLUORINATED PROPRANOLOL ANALOGS : METABOLISM BY CYP 1 A 2
A series of 1 -mono-, di-, and trifluorinated analogs of propranolol and related steric congeners was prepared, and their… 
1986
1986
Mechanisms of lipid peroxidation dependent upon cytochrome P-450 LM2.
A mechanism of lipid peroxidation dependent on the oxidase activity of cytochrome P-450 LM2 in reconstituted membrane vesicles… 
1986
1986
Effect of diethyl ether on the bioactivation, detoxification, and hepatotoxicity of acetaminophen in vitro and in vivo.
Our working hypothesis for designing this study involved early inhibition by ether of P-450-dependent bioactivation and… 
Highly Cited
1982
Highly Cited
1982
Multiplicity strain differences, and topology of phenobarbital-induced cytochromes P-450 in rat liver microsomes.
The multiplicity of phenobarbital-induced cytochromes P-450 in live microsomes from male rats was investigated by using two… 
1980
1980
Effect of diet and drugs on the qualitative and quantitative distribution of cytochromes P-450 in rat liver.
Male Sprague-Dawley rats were fed either Purina chow or a nutritionally adequate liquid control diet containing either 4 or 38… 
1979
1979
Kinetics of reduction of purified liver microsomal cytochrome P-450 in the reconstituted enzyme system studied by stopped flow spectrophotometry.
Stopped flow studies were undertaken to examine the kinetics of reduction of 5,6-benzoflavone-inducible P-450 LM4 by NADPH in the… 
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