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CYP19A1 protein, human

Known as: CYP19, Cytochrome P450, Subfamily XIX, ARO1 protein, human 
Cytochrome P450 19A1 (503 aa, ~58 kDa) is encoded by the human CYP19A1 gene. This protein is involved in the conversion of androgens to estrogens.
National Institutes of Health

Related topics

Related topics

22 relations

Broader (2)

AromataseAryl Hydrocarbon Hydroxylases
Biologic DevelopmentCYP19A1 geneCYP19A1 wt AlleleCytochrome P-450 CYP1A1

Papers overview

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Highly Cited
2015
Highly Cited
2015
Placental Aromatase Is Deficient in Placental Ischemia and Preeclampsia
Introduction Preeclampsia is a maternal hypertensive disorder with uncertain etiology and a leading cause of maternal and fetal… 
2014
2014
Kinetic solvent isotope effect in steady‐state turnover by CYP19A1 suggests involvement of Compound 1 for both hydroxylation and aromatization steps
Highly Cited
2007
Highly Cited
2007
Modulation of human CYP19A1 activity by mutant NADPH P450 oxidoreductase.
Mutations in NADPH P450 oxidoreductase (POR) cause a broad spectrum of human disease with abnormalities in steroidogenesis. We… 
Highly Cited
2007
Highly Cited
2007
La educación científica en la perspectiva del letramiento como práctica social: funciones, principios y desafíos
A partir de visiones sociologicas y filosoficas sobre ciencia, se presenta como vienen siendo discutidas historicamente… 
Highly Cited
2002
Highly Cited
2002
Cloning and characterization of a novel endothelial promoter of the human CYP19 (aromatase P450) gene that is up-regulated in breast cancer tissue.
Intratumoral expression of aromatase P450 (P450arom) promotes the growth of breast tumors via increased local estrogen… 
Highly Cited
1998
Highly Cited
1998
The aromatase excess syndrome is associated with feminization of both sexes and autosomal dominant transmission of aberrant P450 aromatase gene transcription.
Increased extraglandular aromatization has been reported as the cause of familial gynecomastia. We studied a kindred with… 
Highly Cited
1993
Highly Cited
1993
Isolation and characterization of a complementary deoxyribonucleic acid insert encoding bovine aromatase cytochrome P450.
Aromatase, an enzyme complex comprised of aromatase cytochrome P450 (P450arom; the product of the CYP19 gene) and the… 
Highly Cited
1988
Highly Cited
1988
Hormonal regulation, tissue distribution, and content of aromatase cytochrome P450 messenger ribonucleic acid and enzyme in rat ovarian follicles and corpora lutea: relationship to estradiol…
The following study was undertaken to compare the content of aromatase cytochrome P450 (P450arom) mRNA with the content of the… 
Highly Cited
1987
Highly Cited
1987
Aromatase activity in primary and metastatic human breast cancer
Aromatase activity was measured in 104 primary and 24 metastatic breast cancer patients. The assay employed quantitates the… 
Highly Cited
1977
Highly Cited
1977
Massive Extraglandular Aromatization of Plasma Androstenedione Resulting in Feminization of a Prepubertal Boy
Abstract This report describes the mechanism of origin and the quantity of estrogen produced in a prepubertal boy who developed… 
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