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CYP2C18 protein, human

Known as: Cytochrome P450 2C18, Cytochrome P450, Subfamily IIC (Mephenytoin 4-Hydroxylase), Polypeptide 17, P450-2C18 
Cytochrome P450 2C18 (490 aa, ~56 kDa) is encoded by the human CYP2C18 gene. This protein plays a role in the electron transport chain.
National Institutes of Health

Related topics

Related topics

28 relations
Arachidonic Acid Metabolism PathwayAromataseCYP1A1 geneCYP2C18 gene
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Broader (1)

Aryl Hydrocarbon Hydroxylases

Papers overview

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2018
2018
Atrazine Triggers Mitochondrial Dysfunction and Oxidative Stress in Quail ( Coturnix C. coturnix) Cerebrum via Activating Xenobiotic-Sensing Nuclear Receptors and Modulating Cytochrome P450 Systems.
The residues from the widely used broad-spectrum environmental herbicide, atrazine (ATR), result in the exposure of nontarget… Expand
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2018
2018
Atrazine-xenobiotic nuclear receptor interactions induce cardiac inflammation and endoplasmic reticulum stress in quail (Coturnix coturnix coturnix).
Atrazine (ATR) is one of the most extensively used herbicide that eventually leaches into groundwater and surface water from… Expand
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2008
2008
Generation of Mice Transgenic for Human CYP2C18 and CYP2C19: Characterization of the Sexually Dimorphic Gene and Enzyme Expression
CYP2C19 is an important enzyme for human drug metabolism, and it also participates in the metabolism of endogenous substrates… Expand
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2002
2002
Establishment of a transgenic cell line stably expressing human cytochrome P450 2C18 and identification of a CYP2C18 clone with exon 5 missing.
AIM The human cytochrome P-450 2C18(CYP2C18) has been characterized. However, the protein has not been purified from liver and… Expand
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Highly Cited
2001
Highly Cited
2001
Induction of CYP2C genes in human hepatocytes in primary culture.
The expression and inducibility of four CYP2C genes, including CYP2C8, -2C9, -2C18, and -2C19, was investigated in primary… Expand
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1999
1999
Homology modeling and substrate binding study of human CYP2C18 and CYP2C19 enzymes.
It is well established that the variable binding-site architecture and composition of the P450 metabolizing heme proteins are… Expand
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Highly Cited
1999
Highly Cited
1999
Hepatic metabolism of diclofenac: role of human CYP in the minor oxidative pathways.
The aim of this study was to re-examine the human hepatic metabolism of diclofenac, with special focus on the generation of minor… Expand
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1998
1998
Human cytochrome P450-catalyzed conversion of the proestrogenic pesticide methoxychlor into an estrogen. Role of CYP2C19 and CYP1A2 in O-demethylation.
1,1,1-Trichloro-2,2-bis(4-methoxyphenyl)ethane (methoxychlor) is a widely used pesticide that is pro-estrogenic. We have… Expand
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1996
1996
Human CYP2C19 is a major omeprazole 5-hydroxylase, as demonstrated with recombinant cytochrome P450 enzymes.
Omeprazole (OP) is a potent antiulcer drug that is metabolized by liver cytochrome P450 (P450) enzymes. However, the identities… Expand
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1991
1991
Polymerase chain reaction-directed identification, cloning, and quantification of human CYP2C18 mRNA.
Sequencing of genomic polymerase chain reaction (PCR) products synthesized using primers generated from the CYP2C8 and CYP2C9… Expand
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