FAQ

CYP2C18 protein, human

Known as: Cytochrome P450 2C18, Cytochrome P450, Subfamily IIC (Mephenytoin 4-Hydroxylase), Polypeptide 17, P450-2C18 
Cytochrome P450 2C18 (490 aa, ~56 kDa) is encoded by the human CYP2C18 gene. This protein plays a role in the electron transport chain.
National Institutes of Health

Topic mentions per year

Topic mentions per year

1991-2017
02419912017

Related topics

Related topics

29 relations
Arachidonic Acid Metabolism PathwayAromataseCYP1A1 geneCYP2C18 gene
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Broader (1)

Aryl Hydrocarbon Hydroxylases

Related mentions per year

Related mentions per year

1936-2018
19401960198020002020
CYP2C18 protein, human
Oxidation-Reduction
Metabolism
Metabolic Detoxication, Drug
Cytochrome P-450 CYP1A1
drug metabolism

Papers overview

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2008
2008
Generation of mice transgenic for human CYP2C18 and CYP2C19: characterization of the sexually dimorphic gene and enzyme expression.
CYP2C19 is an important enzyme for human drug metabolism, and it also participates in the metabolism of endogenous substrates… (More)
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Highly Cited
2007
Highly Cited
2007
Gene-specific effects of inflammatory cytokines on cytochrome P450 2C, 2B6 and 3A4 mRNA levels in human hepatocytes.
Cytochromes P450 (P450s) are down-regulated in hepatocytes in response to inflammation and infection. This effect has been… (More)
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2006
2006
Regulation of cutaneous drug-metabolizing enzymes and cytoprotective gene expression by topical drugs in human skin in vivo.
BACKGROUND Individuality in the expression and regulation of hepatic drug-metabolizing enzymes (DMEs) and cytoprotective (CP… (More)
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2004
2004
Role of hepatocyte nuclear factor 3 gamma in the expression of human CYP2C genes.
Hepatocyte nuclear factor 3 gamma (HNF-3 gamma) is an important transcription factor for the maintenance of specific liver… (More)
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Highly Cited
2003
Highly Cited
2003
Characterization of the oxidative metabolites of 17beta-estradiol and estrone formed by 15 selectively expressed human cytochrome p450 isoforms.
We systematically characterized the oxidative metabolites of 17beta-estradiol and estrone formed by 15 human cytochrome P450 (CYP… (More)
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Highly Cited
1999
Highly Cited
1999
Hepatic metabolism of diclofenac: role of human CYP in the minor oxidative pathways.
The aim of this study was to re-examine the human hepatic metabolism of diclofenac, with special focus on the generation of minor… (More)
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1998
1998
Human cytochrome P450-catalyzed conversion of the proestrogenic pesticide methoxychlor into an estrogen. Role of CYP2C19 and CYP1A2 in O-demethylation.
1,1,1-Trichloro-2,2-bis(4-methoxyphenyl)ethane (methoxychlor) is a widely used pesticide that is pro-estrogenic. We have… (More)
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1997
1997
Identification of the polymorphically expressed CYP2C19 and the wild-type CYP2C9-ILE359 allele as low-Km catalysts of cyclophosphamide and ifosfamide activation.
Cyclophosphamide and ifosfamide are alkylating agent prodrugs that require activation by cytochrome P450 (CYP) to manifest their… (More)
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1996
1996
Human CYP2C19 is a major omeprazole 5-hydroxylase, as demonstrated with recombinant cytochrome P450 enzymes.
Omeprazole (OP) is a potent antiulcer drug that is metabolized by liver cytochrome P450 (P450) enzymes. However, the identities… (More)
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1995
1995
Transcriptional regulation of human CYP2C genes: functional comparison of CYP2C9 and CYP2C18 promoter regions.
The cytochrome P4502C subfamily comprises a group of constitutive microsomal hemoproteins which are expressed primarily in liver… (More)
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