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CYP2C18 protein, human
Known as:
Cytochrome P450 2C18
, Cytochrome P450, Subfamily IIC (Mephenytoin 4-Hydroxylase), Polypeptide 17
, P450-2C18
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Cytochrome P450 2C18 (490 aa, ~56 kDa) is encoded by the human CYP2C18 gene. This protein plays a role in the electron transport chain.
National Institutes of Health
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Related topics
Related topics
28 relations
Arachidonic Acid Metabolism Pathway
Aromatase
CYP1A1 gene
CYP2C18 gene
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Broader (1)
Aryl Hydrocarbon Hydroxylases
Papers overview
Semantic Scholar uses AI to extract papers important to this topic.
2018
2018
Atrazine Triggers Mitochondrial Dysfunction and Oxidative Stress in Quail ( Coturnix C. coturnix) Cerebrum via Activating Xenobiotic-Sensing Nuclear Receptors and Modulating Cytochrome P450 Systems.
Jia Lin
,
Hua-shan Zhao
,
+4 authors
Jin-Long Li
Journal of agricultural and food chemistry
2018
Corpus ID: 46936465
The residues from the widely used broad-spectrum environmental herbicide, atrazine (ATR), result in the exposure of nontarget…
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Highly Cited
2008
Highly Cited
2008
Generation of Mice Transgenic for Human CYP2C18 and CYP2C19: Characterization of the Sexually Dimorphic Gene and Enzyme Expression
S. Löfgren
,
R. Baldwin
,
+9 authors
M. Ingelman-Sundberg
Drug Metabolism and Disposition
2008
Corpus ID: 9754883
CYP2C19 is an important enzyme for human drug metabolism, and it also participates in the metabolism of endogenous substrates…
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2006
2006
Regulation of cutaneous drug‐metabolizing enzymes and cytoprotective gene expression by topical drugs in human skin in vivo
G. Smith
,
S. Ibbotson
,
+4 authors
C. Wolf
The British journal of dermatology
2006
Corpus ID: 2830351
Background Individuality in the expression and regulation of hepatic drug‐metabolizing enzymes (DMEs) and cytoprotective (CP…
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2002
2002
Establishment of a transgenic cell line stably expressing human cytochrome P450 2C18 and identification of a CYP2C18 clone with exon 5 missing.
J. Zhu-Ge
,
Ying-nian Yu
,
Y. Qian
,
Xin Li
World journal of gastroenterology
2002
Corpus ID: 12900870
AIM The human cytochrome P-450 2C18(CYP2C18) has been characterized. However, the protein has not been purified from liver and…
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Highly Cited
2001
Highly Cited
2001
Induction of CYP2C genes in human hepatocytes in primary culture.
S. Gerbal-Chaloin
,
J. Pascussi
,
+5 authors
P. Maurel
Drug metabolism and disposition: the biological…
2001
Corpus ID: 26874873
The expression and inducibility of four CYP2C genes, including CYP2C8, -2C9, -2C18, and -2C19, was investigated in primary…
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Review
2000
Review
2000
Biotransformation enzyme polymorphism and pesticide susceptibility.
D. Eaton
Neurotoxicology
2000
Corpus ID: 31590384
Numerous specific genetic polymorphisms (PM) in the multi-gene families of cytochromes P450 (CYPs) and glutathione S-transferases…
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1999
1999
Homology modeling and substrate binding study of human CYP2C18 and CYP2C19 enzymes
V. Payne
,
Y. Chang
,
G. Loew
Proteins
1999
Corpus ID: 12283792
It is well established that the variable binding‐site architecture and composition of the P450 metabolizing heme proteins are…
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Highly Cited
1999
Highly Cited
1999
Hepatic metabolism of diclofenac: role of human CYP in the minor oxidative pathways.
R. Bort
,
K. Macé
,
A. Boobis
,
M. Gómez-Lechón
,
A. Pfeifer
,
J. Castell
Biochemical pharmacology
1999
Corpus ID: 46689430
Highly Cited
1998
Highly Cited
1998
Human cytochrome P450-catalyzed conversion of the proestrogenic pesticide methoxychlor into an estrogen. Role of CYP2C19 and CYP1A2 in O-demethylation.
D. Stresser
,
D. Kupfer
Drug metabolism and disposition: the biological…
1998
Corpus ID: 23107654
1,1,1-Trichloro-2,2-bis(4-methoxyphenyl)ethane (methoxychlor) is a widely used pesticide that is pro-estrogenic. We have…
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1991
1991
Polymerase chain reaction-directed identification, cloning, and quantification of human CYP2C18 mRNA.
H. Furuya
,
U. Meyer
,
H. Gelboin
,
F. Gonzalez
Molecular pharmacology
1991
Corpus ID: 23638435
Sequencing of genomic polymerase chain reaction (PCR) products synthesized using primers generated from the CYP2C8 and CYP2C9…
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