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CYP1A2 protein, human

Known as: CYPIA2, Dioxin-Inducible P3-450, P(3)450 
Cytochrome P450 1A2 (515 aa, ~58 kDa) is encoded by the human CYP1A2 gene. This protein is involved in the hydroxylation of fatty acids, steroids and… Expand
National Institutes of Health

Papers overview

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Review
2002
Review
2002
Criteria governing the avidity of substrate binding to human hepatic cytochromes P450 (CYP) associated with Phase 1 metabolism of… Expand
Highly Cited
2002
Highly Cited
2002
1. The aim was to identify the major metabolites of saquinavir (SQV) from human hepatic microsomal incubations and the CYP… Expand
Highly Cited
2000
Highly Cited
2000
Previous in vitro studies in rat microsomal preparations suggested that thalidomide is metabolized by the cytochrome P450 system… Expand
Highly Cited
1998
Highly Cited
1998
AIMS Mexiletine has been reported to be hydroxylated by cytochrome P450 2D6 (CYP2D6) in humans. However, the involvement of… Expand
Highly Cited
1998
Highly Cited
1998
The inhibitory effect of the isoflavonoids genistein and equol on cytochrome P450 activities has been investigated. Genistein and… Expand
Review
1997
Review
1997
1. The CYP4 family consists of 11 subfamilies (CYP4A-CYP4M), which encode constitutive and inducible isozymes expressed in both… Expand
Highly Cited
1995
Highly Cited
1995
The highly specific mechanism of action of the selective serotonin re-uptake inhibitors (SSRIs) confers advantages on this group… Expand
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Highly Cited
1994
Highly Cited
1994
Cigarette smoking is a leading risk factor for atherosclerosis. Endothelial injury may be the initial event in this process. The… Expand
Highly Cited
1993
Highly Cited
1993
1. The effects of grapefruit juice and naringenin on the activity of the human cytochrome P450 isoform CYP1A2 were evaluated… Expand
Highly Cited
1983
Highly Cited
1983
The effects of diabetes on the liver microsomal monooxygenase enzymes and carcinogen metabolism have been studied in rats… Expand