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CYP1A2 protein, human

Known as: CYPIA2, Dioxin-Inducible P3-450, P(3)450 
Cytochrome P450 1A2 (515 aa, ~58 kDa) is encoded by the human CYP1A2 gene. This protein is involved in the hydroxylation of fatty acids, steroids and… 
National Institutes of Health

Papers overview

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Highly Cited
2013
Highly Cited
2013
Although the mechanism underlying the effect of androgen on BP and cardiovascular disease is not well understood, recent studies… 
Review
2002
Review
2002
Criteria governing the avidity of substrate binding to human hepatic cytochromes P450 (CYP) associated with Phase 1 metabolism of… 
Review
2001
Review
2001
Atypical antipsychotics such as clozapine represent a significant improvement over typical antipsychotics in the treatment of… 
Highly Cited
2000
Highly Cited
2000
Previous in vitro studies in rat microsomal preparations suggested that thalidomide is metabolized by the cytochrome P450 system… 
Highly Cited
1998
Highly Cited
1998
AIMS Mexiletine has been reported to be hydroxylated by cytochrome P450 2D6 (CYP2D6) in humans. However, the involvement of… 
Review
1997
Review
1997
  • A. Simpson
  • General pharmacology
  • 1997
  • Corpus ID: 25738542
Review
1997
Review
1997
  • David Taylor
  • British Journal of Psychiatry
  • 1997
  • Corpus ID: 5033129
Background Metabolism of clozapine is complex and not fully understood. Pharmacokinetic interactions with other drugs have been… 
Highly Cited
1995
Highly Cited
1995
The highly specific mechanism of action of the selective serotonin re-uptake inhibitors (SSRIs) confers advantages on this group… 
Highly Cited
1994
Highly Cited
1994
The contribution of CYP1A2 to the metabolism of the dietary heterocyclic amines, 2-amino-1-methyl-6-phenylimidazo[4,5-b]pyridine… 
Highly Cited
1993
Highly Cited
1993
1. The effects of grapefruit juice and naringenin on the activity of the human cytochrome P450 isoform CYP1A2 were evaluated…