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CYP1A2 protein, human

Known as: CYPIA2, Dioxin-Inducible P3-450, P(3)450 
Cytochrome P450 1A2 (515 aa, ~58 kDa) is encoded by the human CYP1A2 gene. This protein is involved in the hydroxylation of fatty acids, steroids and… Expand
National Institutes of Health

Papers overview

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2013
2013
Although the mechanism underlying the effect of androgen on BP and cardiovascular disease is not well understood, recent studies… Expand
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Review
2002
Review
2002
Criteria governing the avidity of substrate binding to human hepatic cytochromes P450 (CYP) associated with Phase 1 metabolism of… Expand
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2000
2000
Previous in vitro studies in rat microsomal preparations suggested that thalidomide is metabolized by the cytochrome P450 system… Expand
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2000
2000
CYP1A2 activity has been demonstrated to be bimodally or trimodally distributed in several populations, consistent with a… Expand
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1998
1998
The inhibitory effect of the isoflavonoids genistein and equol on cytochrome P450 activities has been investigated. Genistein and… Expand
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1998
1998
AIMS Mexiletine has been reported to be hydroxylated by cytochrome P450 2D6 (CYP2D6) in humans. However, the involvement of… Expand
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Review
1997
Review
1997
1. The CYP4 family consists of 11 subfamilies (CYP4A-CYP4M), which encode constitutive and inducible isozymes expressed in both… Expand
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1995
1995
The highly specific mechanism of action of the selective serotonin re-uptake inhibitors (SSRIs) confers advantages on this group… Expand
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1994
1994
Cigarette smoking is a leading risk factor for atherosclerosis. Endothelial injury may be the initial event in this process. The… Expand
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Highly Cited
1993
Highly Cited
1993
1. The effects of grapefruit juice and naringenin on the activity of the human cytochrome P450 isoform CYP1A2 were evaluated… Expand
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