CYP1A2 protein, human

Known as: CYPIA2, Dioxin-Inducible P3-450, P(3)450 
Cytochrome P450 1A2 (515 aa, ~58 kDa) is encoded by the human CYP1A2 gene. This protein is involved in the hydroxylation of fatty acids, steroids and… (More)
National Institutes of Health

Topic mentions per year

Topic mentions per year

1974-2018
051019742018

Papers overview

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2007
2007
We investigated the associations between lung cancer and the gene polymorphisms of the drug metabolizing enzymes, containing… (More)
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2002
2002
1. The aim was to identify the major metabolites of saquinavir (SQV) from human hepatic microsomal incubations and the CYP… (More)
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1998
1998
Phenacetin O-deethylation, widely used as an index reaction for cytochrome P450 1A2 (CYP1A2) activity, displays biphasic kinetics… (More)
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1998
1998
OBJECTIVE In order to reliably predict in vivo pharmacokinetic parameters from in vitro data, we must thoroughly understand the… (More)
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Highly Cited
1995
Highly Cited
1995
The relationships between smoking and the expression of glutathione S-transferase (GST*) isozymes GSTM1-1, GSTM3-3, GSTP1-1 and… (More)
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1994
1994
Cigarette smoking is a leading risk factor for atherosclerosis. Endothelial injury may be the initial event in this process. The… (More)
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Highly Cited
1993
Highly Cited
1993
Biotransformation reactions catalyzed by human cytochrome P450 1A2 (P450 1A2) appear to play a significant role in both the… (More)
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1993
1993
1. The effects of grapefruit juice and naringenin on the activity of the human cytochrome P450 isoform CYP1A2 were evaluated… (More)
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1991
1991
English sole (Parophrys vetulus) are susceptible to the development of hepatic disease, including neoplasia, as a result of… (More)
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Highly Cited
1978
Highly Cited
1978
The elimination of caffeine from saliva was compared in groups of healthy smokers (n = 13) and nonsmokers (n = 13). Mean caffeine… (More)
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