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CYP1A2 protein, human

Known as: CYPIA2, Dioxin-Inducible P3-450, P(3)450 
Cytochrome P450 1A2 (515 aa, ~58 kDa) is encoded by the human CYP1A2 gene. This protein is involved in the hydroxylation of fatty acids, steroids and… 
National Institutes of Health

Related topics

Related topics

50 relations
AcetaminophenAmitriptylineAmitriptyline HydrochlorideCYP1A2 gene

Broader (3)

Aryl Hydrocarbon HydroxylasesCytochrome P-450 CYP1A2Xenobiotic Monooxygenases

Papers overview

Semantic Scholar uses AI to extract papers important to this topic.
Review
2006
Review
2006
Pharmacokinetic changes of drugs in rat model of acute renal failure induced by uranyl nitrate: correlation between drug metabolism and hepatic microsomal cytochrome P450 isozymes.
In male Sprague-Dawley rat model of acute renal failure induced by uranyl nitrate (rat model of U-ARF), the expression of CYP2C11… 
2001
2001
Application of the PKCYP-test to predict the amount of in vivo CYP2C11 using tolbutamide as a probe.
Previous reports have shown that the determination of drug metabolism capacity can be made by the pharmacokinetic estimation of… 
Highly Cited
2000
Highly Cited
2000
Metabolism of thalidomide in human microsomes, cloned human cytochrome P‐450 isozymes, and Hansen’s disease patients
Previous in vitro studies in rat microsomal preparations suggested that thalidomide is metabolized by the cytochrome P450 system… 
2000
2000
Identification of novel polymorphisms in the 5' flanking region of CYP1A2, characterization of interethnic variability, and investigation of their functional significance.
CYP1A2 activity has been demonstrated to be bimodally or trimodally distributed in several populations, consistent with a… 
Highly Cited
1998
Highly Cited
1998
Inhibition of mouse and human CYP 1A- and 2E1-dependent substrate metabolism by the isoflavonoids genistein and equol.
1992
1992
"Oxidative stress" response in liver of an untreated newborn mouse having a 1.2-centimorgan deletion on chromosome 7.
1990
1990
Immunochemical and molecular biological studies on human placental cigarette smoke-inducible cytochrome P-450-dependent monooxygenase activities.
1990
1990
The influence of age on the inducibility of rat liver cytochrome P450IA1 (CYPIA1) and P450IA2 (CYPIA2) mRNAs.
1984
1984
Human skin aryl hydrocarbon hydroxylase
Aryl hydrocarbon hydroxylase (AHH) activity has been measured in full‐thickness biopsies of human skin from patients with and… 
1979
1979
The activity of aryl hydrocarbon hydroxylase in adult human skin.
1 Aryl hydrocarbon hydroxylase (AHH), a mixed-function oxidase system, has been identified in microsomal preparations of adult… 
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