Share This Author
Regulation of JNK signaling by GSTp
The relationships between GSTp expression and its association with JNK are demonstrated and new insight is provided into the regulation of stress kinases.
Cytochrome P450 specificities of alkoxyresorufin O-dealkylation in human and rat liver.
Identification of genetic polymorphisms at the glutathione S-transferase Pi locus and association with susceptibility to bladder, testicular and prostate cancer.
A novel PCR assay has been developed which demonstrates that these two variant cDNAs represent distinct GSTP 1 alleles (GSTP1a and GSTP1b), which are found to be strongly associated with bladder cancer and testicular cancer and in prostate cancer a highly significant decrease was observed.
The Cap'n'Collar basic leucine zipper transcription factor Nrf2 (NF-E2 p45-related factor 2) controls both constitutive and inducible expression of intestinal detoxification and glutathione…
In the small intestine, the constitutive level of NQO1 is lower in the Nrf2-/- mouse, and immunoblotting showed that induction of the oxidoreductase was substantially diminished in the mutant mouse.
Inactivation of the Hepatic Cytochrome P450 System by Conditional Deletion of Hepatic Cytochrome P450 Reductase*
Hepatic CPR-null mice developed normally and were able to breed, indicating that hepatic microsomal P450-mediated steroid hormone metabolism is not essential for fertility, demonstrating that a major evolutionary role for hepatic P450s is to protect mammals from their environment.
Increased skin tumorigenesis in mice lacking pi class glutathione S-transferases.
- C. Henderson, A. Smith, J. Ure, K. Brown, E. Bacon, C. Wolf
- Biology, MedicineProceedings of the National Academy of Sciences…
- 28 April 1998
A difference in tumor incidence provides direct evidence that a single gene involved in drug metabolism can have a profound effect on tumorigenicity, and demonstrates that GstP may be an important determinant in cancer susceptibility, particularly in diseases where exposure to polycyclic aromatic hydrocarbons is involved, for instance in cigarette smoke-induced lung cancer.
The Nrf2 transcription factor contributes both to the basal expression of glutathione S-transferases in mouse liver and to their induction by the chemopreventive synthetic antioxidants, butylated…
Significantly, residual induction of GST by antioxidants is apparent in the Nrf2 mutant mouse, indicating the existence of an alternative mechanism of gene activation.
Generation of a stable antioxidant response element-driven reporter gene cell line and its use to show redox-dependent activation of nrf2 by cancer chemotherapeutic agents.
The findings show that Nrf2 can be activated by certain anticancer agents, and this will influence the effectiveness of chemotherapy.
Human constitutive androstane receptor (CAR) and pregnane X receptor (PXR) support the hypertrophic but not the hyperplastic response to the murine nongenotoxic hepatocarcinogens phenobarbital and…
- Jillian D. Ross, S. Plummer, C. Elcombe
- BiologyToxicological sciences : an official journal of…
- 1 August 2010
Mouse nongenotoxic hepatocarcinogens phenobarbital and chlordane induce hepatomegaly characterized by hypertrophy and hyperplasia, suggesting that the human receptors are able to support the chemically induced hypertrophic responses but not the hyperplastic responses.
The Peroxisome Proliferator-activated Receptor δ Promotes Lipid Accumulation in Human Macrophages*
Data suggest that PPARδ may play a role in the pathology of diseases associated with lipid-filled macrophages, such as atherosclerosis, arthritis, and neurodegeneration.