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The 2005 World Health Organization reevaluation of human and Mammalian toxic equivalency factors for dioxins and dioxin-like compounds.
Concern was expressed about direct application of the TEF/total toxic equivalency (TEQ) approach to abiotic matrices, such as soil, sediment, etc., for direct application in human risk assessment as the present TEF scheme and TEQ methodology are primarily intended for estimating exposure and risks via oral ingestion. Expand
Cytochrome P450
It is shown that in allylic hydroxyl ations (catalyzed by either model metalloporphyrins or cytochrome P450) rehydridization could occur to yield multiple products. Expand
Brominated flame retardants: cause for concern?
Scientific issues associated with the use of tetrabromobisphenol A, hexabromocyclodododecane, and three commercial mixtures of polybrominated diphenyl ethers are reviewed and data gaps are discussed. Expand
Polybrominated diphenyl ethers (PBDEs) in U.S. mothers' milk.
The results indicate a need for more detailed investigation of the levels of PBDE in people and food, as well as determining if animal fat in food is the major route of exposure of the general U.S. population. Expand
In vivo effects of bisphenol A in laboratory rodent studies.
It is likely, but requiring further confirmation, that adult exposure to BPA affects the brain, the female reproductive system, and the immune system and that developmental effects occur in theFemale reproductive system. Expand
Polybrominated Diphenyl Ether (PBDE) Levels in an Expanded Market Basket Survey of U.S. Food and Estimated PBDE Dietary Intake by Age and Sex
The indoor environment (dust, air) may play an important role in PBDE body burdens in addition to food, and dietary exposure alone does not appear to account for the very high body burdens measured. Expand
Re Human and Mammalian Toxic Equivalency Factors for Dioxins and Dioxin-Like Compounds: The Who 2005 Re-Evaluation
Re Human and Mammalian Toxic Equivalency Factors for Dioxins and Dioxin-Like Compounds: The Who 2005 Re-Evaluation
Dioxins: an overview.
This review article summarizes what is known about human health following exposure to dioxins. It is meant primarily for health professionals but was also written with the general public in mind. TheExpand
Polybrominated diphenyl ethers contamination of United States food.
U.S. food PBDE levels measured in this study are higher than reported in two other published market based studies from Spain and Japan, suggesting that food is a major route of intake for PBDEs. Expand
Development of a refined database of mammalian relative potency estimates for dioxin-like compounds.
  • L. Haws, S. Su, +5 authors L. Birnbaum
  • Computer Science, Medicine
  • Toxicological sciences : an official journal of…
  • 2006
A refined database of mammalian REPs is presented that is believed to improve risk assessment for this class of compounds by including additional information from new studies and facilitating the use of quantitative approaches in the further development of TEFs. Expand