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P450 superfamily: update on new sequences, gene mapping, accession numbers and nomenclature.
This revision supersedes the four previous updates in which a nomenclature system, based on divergent evolution of the P450 superfamily has been described and is similar to that proposed in the previous updates. Expand
[7] Mitochondrial respiratory control and the polarographic measurement of ADP : O ratios
Publisher Summary This chapter discusses the mitochondrial respiratory control and the polarographic measurement of ADP : O ratios. The polarographic oxygen electrode technique is used for measuringExpand
The P450 superfamily: update on new sequences, gene mapping, accession numbers, early trivial names of enzymes, and nomenclature.
The likelihood that this ancient gene superfamily has existed for more than 3.5 billion years, and that the rate of P450 gene evolution appears to be quite nonlinear, is discussed. Expand
Measurement of steroid hydroxylation reactions by high-performance liquid chromatography as indicator of P450 identity and function.
It is etablished that the regio- and stereospecific hydroxylation of the steroid nucleus is a sensitive fingerprint for the identification of a specific type of cytochrome P450. Expand
Spectral studies of drug interaction with hepatic microsomal cytochrome.
Two types of spectral changes are described as resulting from substrate interaction with a hepatic microsomal cytochrome; the magnitude of these spectral changes is dependent on protein concentrationExpand
Human cytochromes P450
This review deals with aspects of cytochrome P450s of relevance to human physiology, biochemistry, pharmacology and medicine, including their role in metabolism of endogenous compounds such as steroids and eicosanoids, and the effect of disease on CYP function, CYPs and cancer. Expand
The P450 superfamily: update on new sequences, gene mapping, and recommended nomenclature.
A modest revision of the initially proposed and updated nomenclature system for P450 of all eukaryotes and prokaryotes based on evolution of the superfamily is proposed, discouraging the future use of cumbersome Roman numerals. Expand
The P450 gene superfamily: recommended nomenclature.
A nomenclature for the P450 gene superfamily is proposed based on evolution. Recommendations include Roman numerals for distinct gene families, capital letters for subfamilies, and Arabic numeralsExpand
Cytochrome P450 and the arachidonate cascade 1
Arachidonic acid and many products of the arachidonate cascade serve as substrates for cytochrome P450‐mediated metabolism via allylic oxidation, omega hydroxylation, and epoxygenation as well asExpand
A pathway for the metabolism of vitamin D3: Unique hydroxylated metabolites formed during catalysis with cytochrome P450scc (CYP11A1)
In vitro experiments using purified mitochondrial cytochrome P450scc (CYP11A1) reconstituted with the iron-sulfer protein, adrenodoxin, and the flavoprotein, adren Orthodoxin reductase show the NADPH and time-dependent formation of two major metabolites of D3 plus two unknown minor metabolites. Expand