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Specificity of substrate and inhibitor probes for human cytochromes P450 1A1 and 1A2.
Kinetic and inhibitor studies using cDNA-expressed enzymes and human liver microsomes have characterized the specificity of a range of cytochrome P450 (CYP) 1A substrate and inhibitor probes towardsExpand
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Hydroxylation of warfarin by human cDNA-expressed cytochrome P-450: a role for P-4502C9 in the etiology of (S)-warfarin-drug interactions.
Previous kinetic studies have identified a high-affinity (S)-warfarin 7-hydroxylase present in human liver microsomes which appears to be responsible for the termination of warfarin's biologicalExpand
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Activation of CYP3A4: evidence for the simultaneous binding of two substrates in a cytochrome P450 active site.
A unique characteristic of the CYP3A subfamily of cytochrome P450 enzymes is their ability to be activated by certain compounds. It is reported that CYP3A4-catalyzed phenanthrene metabolism isExpand
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Cytochrome P-450 hPCN3, a novel cytochrome P-450 IIIA gene product that is differentially expressed in adult human liver. cDNA and deduced amino acid sequence and distinct specificities of
Immunoblotting analysis of human liver microsome preparations revealed that human cytochrome P-450 PCN1 (hPCN1, Mr approximately 52,000) was expressed in each of 40 individual specimens examined. InExpand
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Further characterization of the expression in liver and catalytic activity of CYP2B6.
Previous studies in this laboratory have determined the lack of specificity of several antibody and substrate probes of CYP2B6. The goals of the current study were to examine the expression of CYP2B6Expand
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Styrene metabolism by cDNA-expressed human hepatic and pulmonary cytochromes P450.
The rate of formation of styrene glycol from styrene was compared in human, rat, and mouse liver microsomes. At a low styrene concentration (0.085 mM), the rates decreased in the order, mouse (2.43Expand
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Steroid hormone hydroxylase specificities of eleven cDNA-expressed human cytochrome P450s.
Steroid hydroxylation specificities were determined for 11 forms of human cytochrome P450, representing four gene families and eight subfamilies, that were synthesized in human hepatoma Hep G2 cellsExpand
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Assessment of specificity of eight chemical inhibitors using cDNA-expressed cytochromes P450
  • Y. Sai, R. Dai, +4 authors M. Shou
  • Chemistry, Medicine
  • Xenobiotica; the fate of foreign compounds in…
  • 1 January 2000
1. The selectivity of eight chemical inhibitors has been extensively evaluated with 10 cDNA-expressed human cytochrome P450 isoforms (CYP). The results indicate that sulphaphenazole, quinidine andExpand
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