Skip to search formSkip to main contentSkip to account menu
  • Publications
  • Influence
Free radicals in biology and medicine (2nd Edition) : By Barry Halliwell and John M.C. Gutteridge; Clarendon Press; Oxford, 1989; xvi + 543 pages; £50.00 (cloth), £22.50 (paperback)
View via Publisher
Chemical toxicity and reactive oxygen species.
  • D. Parke, A. Sapota
  • Medicine, Biology
    International journal of occupational medicine…
  • 1996
TLDR
Many industrial workers with symptoms of systemic inflammation, resulting from exposure to toxic chemicals, are diagnosed as having rheumatoid arthritis, virus infections, or other microbial lesions, largely because many physicians are unaware that exposure to certain chemicals can initiate inflammatory disease states.
View on PubMed
Cytochromes P450 and species differences in xenobiotic metabolism and activation of carcinogen.
TLDR
This paper focuses on examples in which species differences in P450s lead to significant alterations in carcinogenic response, and includes a discussion of the current procedures for toxicity screening, with an emphasis on short-term tests.
View on PubMed
The cytochromes P450 and mechanisms of chemical carcinogenesis.
  • D. Parke
  • Biology
    Environmental health perspectives
  • 1 October 1994
This article reviews mechanisms of chemical carcinogenesis, from metabolic activation and generation of reactive oxygen species by cytochromes P4511 and P4502E to DNA damage, activation of protein…
View on PubMed
The cytochrome P450 I gene family of microsomal hemoproteins and their role in the metabolic activation of chemicals.
View on PubMed
Studies in detoxication. XLIX. The metabolism of benzene containing (14C1) benzene.
View on PubMed
The toxicity of benzene and its metabolism and molecular pathology in human risk assessment.
TLDR
Regulators should proceed with caution before making further changes to the exposure limit for benzene, which involves multiple mechanisms including synergism between arylating and glutathione-depleting reactive metabolites and oxygen radicals.
View on BMJ
Molecular dimensions of the substrate binding site of cytochrome P-448.
View on PubMed
The metabolism of [2-14C] indole in the rat.
TLDR
Indole is metabolized by two pathways, one via indoxyl to isatin, N-formylanthranilic acid and anthranilic Acid, and the other via oxindole to 5-hydroxyoxindole and possibly to o-aminophenylacetic and anthanilic acid.
View on PubMed
Studies in detoxication. 62. The metabolism of halogenobenzenes; ortho- and para-dichlorobenzenes.
View on PubMed
...
...
By clicking accept or continuing to use the site, you agree to the terms outlined in our Privacy Policy, Terms of Service, and Dataset License