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Cytochrome P450

Known as: Cytochrome-P450, Superfamily, Cytochrome P450, cytochrome P450 enzyme system 
A superfamily of hundreds of closely related HEMEPROTEINS found throughout the phylogenetic spectrum, from animals, plants, fungi, to bacteria. They… 
National Institutes of Health

Related topics

Related topics

50 relations

Narrower (41)

17,20-Lyase Deficiency, IsolatedAldosterone SynthaseCYP119 protein, Sulfolobus solfataricusCYP2B17 protein, Macaca mulatta
CYP4V2 geneEnzyme GeneHemeproteinsIn Blood

Broader (1)

Mixed Function Oxygenases

Papers overview

Semantic Scholar uses AI to extract papers important to this topic.
Highly Cited
2008
Highly Cited
2008
The Endocannabinoid Anandamide Is a Substrate for the Human Polymorphic Cytochrome P450 2D6
Members of the cytochrome P450 (P450) family of drug-metabolizing enzymes are present in the human brain, and they may have… 
Highly Cited
2004
Highly Cited
2004
Structure of Mammalian Cytochrome P450 2B4 Complexed with 4-(4-Chlorophenyl)imidazole at 1.9-Å Resolution
A 1.9-Å molecular structure of the microsomal cytochrome P450 2B4 with the specific inhibitor 4-(4-chlorophenyl)imidazole (CPI… 
Highly Cited
2004
Highly Cited
2004
A predictive pattern of computed barriers for C-h hydroxylation by compound I of cytochrome p450.
The communication presents DFT calculations of 10 different C-H hydroxylation barriers by the active species of the enzyme… 
Review
1995
Review
1995
Recent Advances: the Cytochrome P450 Enzymes
Successful application of information on cytochrome P450 to prevent drug interactions and improve the therapeutic risk: benefit… 
Review
1995
Review
1995
Oxygen and xenobiotic reductase activities of cytochrome P450.
The oxygen reductase and xenobiotic reductase activities of cytochrome P450 (P450) are reviewed. During the oxygen reductase… 
Review
1995
Review
1995
Diagnosis of polymorphisms in carcinogen-activating and inactivating enzymes and cancer susceptibility--a review.
Highly Cited
1989
Highly Cited
1989
Cytochrome P-450 hPCN3, a novel cytochrome P-450 IIIA gene product that is differentially expressed in adult human liver. cDNA and deduced amino acid sequence and distinct specificities of cDNA…
Immunoblotting analysis of human liver microsome preparations revealed that human cytochrome P-450 PCN1 (hPCN1, Mr approximately… 
Highly Cited
1989
Highly Cited
1989
Roles of individual human cytochrome P-450 enzymes in the bioactivation of benzo(a)pyrene, 7,8-dihydroxy-7,8-dihydrobenzo(a)pyrene, and other dihydrodiol derivatives of polycyclic aromatic…
Human liver microsomes oxidized 7,8-dihydroxy-7,8-dihydrobenzo(a)pyrene [B(a)P-7,8-diol] to products that yield DNA adduct… 
Highly Cited
1984
Highly Cited
1984
An alternative 7-ethoxyresorufin O-deethylase activity assay: a continuous visible spectrophotometric method for measurement of cytochrome P-450 monooxygenase activity.
Highly Cited
1977
Highly Cited
1977
Separation of pure polychlorinated biphenyl isomers into two types of inducers on the basis of induction of cytochrome P-450 or P-448.
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