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Cytochrome P450
Known as:
Cytochrome-P450
, Superfamily, Cytochrome P450
, cytochrome P450 enzyme system
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A superfamily of hundreds of closely related HEMEPROTEINS found throughout the phylogenetic spectrum, from animals, plants, fungi, to bacteria. They…
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National Institutes of Health
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Related topics
Related topics
50 relations
Narrower (41)
17,20-Lyase Deficiency, Isolated
Aldosterone Synthase
CYP119 protein, Sulfolobus solfataricus
CYP2B17 protein, Macaca mulatta
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CYP4V2 gene
Enzyme Gene
Hemeproteins
In Blood
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Broader (1)
Mixed Function Oxygenases
Papers overview
Semantic Scholar uses AI to extract papers important to this topic.
Review
2013
Review
2013
Cytochrome P450 enzymes in drug metabolism: regulation of gene expression, enzyme activities, and impact of genetic variation.
U. Zanger
,
M. Schwab
Pharmacology and Therapeutics
2013
Corpus ID: 24631027
Highly Cited
2010
Highly Cited
2010
Cytochrome P450 Compound I: Capture, Characterization, and C-H Bond Activation Kinetics
J. Rittle
,
Michael T. Green
Science
2010
Corpus ID: 206528205
The Power Behind P450 Drugs, toxins and a range of metabolic substrates are detoxified in the liver by family of iron-containing…
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Highly Cited
2009
Highly Cited
2009
The Cytochrome P450 Homepage
D. Nelson
Human Genomics
2009
Corpus ID: 24052788
The Cytochrome P450 Homepage is a universal resource for nomenclature and sequence information on cytochrome P450 (CYP) genes…
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Review
2008
Review
2008
Cytochrome p450 and chemical toxicology.
F. Guengerich
Chemical Research in Toxicology
2008
Corpus ID: 17548932
The field of cytochrome P450 (P450) research has developed considerably over the past 20 years, and many important papers on the…
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Review
2007
Review
2007
The effect of cytochrome P450 metabolism on drug response, interactions, and adverse effects.
T. Lynch
,
Amy L. Price
American Family Physician
2007
Corpus ID: 33933519
Cytochrome P450 enzymes are essential for the metabolism of many medications. Although this class has more than 50 enzymes, six…
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Review
2005
Review
2005
Genetic polymorphisms of cytochrome P450 2D6 (CYP2D6): clinical consequences, evolutionary aspects and functional diversity
M. Ingelman-Sundberg
The Pharmacogenomics Journal
2005
Corpus ID: 10695794
CYP2D6 is of great importance for the metabolism of clinically used drugs and about 20–25% of those are metabolised by this…
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Review
2004
Review
2004
Mechanism of oxidation reactions catalyzed by cytochrome p450 enzymes.
B. Meunier
,
S. D. de Visser
,
S. Shaik
Chemical Reviews
2004
Corpus ID: 33927145
ion phase that leads to an alkyl radical coordinated to the iron-hydroxo complex by a weak OH---C hydrogen bond, labeled as CI…
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Review
2001
Review
2001
Common and uncommon cytochrome P450 reactions related to metabolism and chemical toxicity.
F. Guengerich
Chemical Research in Toxicology
2001
Corpus ID: 32038435
Cytochrome P450 (P450) enzymes catalyze a variety of reactions and convert chemicals to potentially reactive products as well as…
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Review
1998
Review
1998
Inhibition and Induction of Cytochrome P450 and the Clinical Implications
J. Lin
,
A. Y. Lu
Clinical Pharmacokinetics
1998
Corpus ID: 11393482
The cytochrome P450s (CYPs) constitute a superfamily of isoforms that play an important role in the oxidative metabolism of drugs…
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Review
1992
Review
1992
The human hepatic cytochromes P450 involved in drug metabolism.
S. Wrighton
,
J. Stevens
Critical Reviews in Toxicology
1992
Corpus ID: 7580390
The cytochromes P450 are a superfamily of hemoproteins that catalyze the metabolism of a large number of xenobiotics and…
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