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Aldosterone Synthase

Known as: Steroid 18 Hydroxylase, Cytochrome P-450 CYP11B2, Aldosterone Synthase Cytochrome P-450 
A mitochondrial cytochrome P450 enzyme that catalyzes the 18-hydroxylation of steroids in the presence of molecular oxygen and NADPH-specific… 
National Institutes of Health

Related topics

Related topics

14 relations
CYP11B2 geneIn BloodProcess of secretionSteroid 11-beta-Monooxygenase

Narrower (4)

CYP11B2 protein, humanCorticosterone Methyl Oxidase Type I Deficiencycorticosterone methyl oxidase Icorticosterone methyl oxidase II

Broader (1)

Cytochrome P450

Papers overview

Semantic Scholar uses AI to extract papers important to this topic.
2009
2009
Association of the -344T/C aldosterone synthase gene variant with essential hypertension.
The aldosterone synthase gene (CYP11B2) is an important candidate gene region in essential hypertension. We therefore studied the… 
Review
2006
Review
2006
CYP17- and CYP11B-dependent steroid hydroxylases as drug development targets.
Highly Cited
2004
Highly Cited
2004
Postoperative differentiation between unilateral adrenal adenoma and bilateral adrenal hyperplasia in primary aldosteronism by mRNA expression of the gene CYP11B2.
OBJECTIVE Primary aldosteronism (PA) is characterized by hypertension, hypokalemia and suppressed renin-angiotensin system caused… 
Highly Cited
2001
Highly Cited
2001
Modelling of three-dimensional structures of cytochromes P450 11B1 and 11B2.
2001
2001
In vitro release of aldosterone and cortisol in human adrenal adenomas correlates to mRNA expression of steroidogenic enzymes for genes CYP11B2 and CYP17
Adenomas of the adrenal cortex cause different disorders depending on the main steroid synthesized and released. The aim of this… 
1999
1999
Interaction of CYP11B1 (cytochrome P-45011 beta) with CYP11A1 (cytochrome P-450scc) in COS-1 cells.
The interactions of CYP11B1 (cytochrome P-45011beta), CYP11B2 (cytochrome P-450aldo) and CYP11A1 (cytochrome P-450scc) were… 
1998
1998
Implication of ZOG protein (zona glomerulosa-specific protein) in zone development of the adrenal cortex.
The three zones of adrenal cortex are thought to arise from a single multipotential stem cell. Immunohistochemical studies of… 
1995
1995
Artificial mutations in P450c11AS (aldosterone synthase) can increase enzymatic activity: a model for low-renin hypertension?
The conversion of 11-deoxycorticosterone (DOC) to aldosterone is catalyzed by a single enzyme, termed P450c11AS, which has 11… 
Highly Cited
1994
Highly Cited
1994
Role of adrenal renin in the regulation of adrenal steroidogenesis by corticotropin.
The major regulator of mineralocorticoid production in the adrenal is angiotensin II produced by the action of renal renin. The… 
1964
1964
INTRACELLULAR DISTRIBUTION AND PROPERTIES OF STEROID 11-BETA-HYDROXYLASE AND STEROID 18-HYDROXYLASE IN RAT ADRENAL.
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