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It is shown that in allylic hydroxyl ations (catalyzed by either model metalloporphyrins or cytochrome P450) rehydridization could occur to yield multiple products.
P450 superfamily: update on new sequences, gene mapping, accession numbers and nomenclature.
This revision supersedes the four previous updates in which a nomenclature system, based on divergent evolution of the P450 superfamily has been described and is similar to that proposed in the previous updates.
The P450 superfamily: update on new sequences, gene mapping, accession numbers, early trivial names of enzymes, and nomenclature.
The likelihood that this ancient gene superfamily has existed for more than 3.5 billion years, and that the rate of P450 gene evolution appears to be quite nonlinear, is discussed.
Cytochrome P450: nature's most versatile biological catalyst.
- M. J. Coon
- BiologyAnnual review of pharmacology and toxicology
Present knowledge of the individual steps in the P450 and reductase reaction cycles is summarized, including evidence for the generation of multiple functional oxidants that may contribute to the exceptional diversity of the reactions catalyzed.
The P450 superfamily: update on new sequences, gene mapping, and recommended nomenclature.
A modest revision of the initially proposed and updated nomenclature system for P450 of all eukaryotes and prokaryotes based on evolution of the superfamily is proposed, discouraging the future use of cumbersome Roman numerals.
The P450 gene superfamily: recommended nomenclature.
A nomenclature for the P450 gene superfamily is proposed based on evolution. Recommendations include Roman numerals for distinct gene families, capital letters for subfamilies, and Arabic numerals…
Inactivation of key metabolic enzymes by mixed-function oxidation reactions: possible implication in protein turnover and ageing.
- L. Fucci, C. Oliver, M. J. Coon, E. Stadtman
- Biology, ChemistryProceedings of the National Academy of Sciences…
- 1 March 1983
It is suggested that mixed-function oxidation system-catalyzed inactivation of enzymes is a regulatory step in enzyme turn-over and the implication of oxidative inactivation reactions in ageing is suggested by the fact that many of the enzymes inactivated by mixed- function oxidation systems are known to accumulate as inactive forms during ageing.
Epoxidation of olefins by cytochrome P450: evidence from site-specific mutagenesis for hydroperoxo-iron as an electrophilic oxidant.
- A. Vaz, D. Mcginnity, M. J. Coon
- Chemistry, BiologyProceedings of the National Academy of Sciences…
- 31 March 1998
Results and a comparison of the ratios of the rates of epoxidation and hydroxylation support the concept that two different species with electrophilic properties, hydroperoxo-iron (FeO2H)3+ and oxenoid-iron(FeO)3+, can effect olefinEpoxidation.
Cytochrome P-450. Multiplicity of isoforms, substrates, and catalytic and regulatory mechanisms.