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THE CARBON MONOXIDE-BINDING PIGMENT OF LIVER MICROSOMES. I. EVIDENCE FOR ITS HEMOPROTEIN NATURE.
  • T. Omura, R. Sato
  • Biology, Medicine
  • The Journal of biological chemistry
  • 1 July 1964
TLDR
The present paper gives a detailed account of the investigations on rabbit liver microsomes and crude microsomal digests, which have led to postulate the hemoprotein nature of the pigment. Expand
THE CARBON MONOXIDE-BINDING PIGMENT OF LIVER MICROSOMES. II. SOLUBILIZATION, PURIFICATION, AND PROPERTIES.
  • T. Omura, R. Sato
  • Biology, Medicine
  • The Journal of biological chemistry
  • 1 July 1964
TLDR
The present paper gives a detailed account of the investigations on rabbit liver microsomes and crude microsomal digests, which have led to postulate the hemoprotein nature of the pigment. Expand
A new cytochrome in liver microsomes.
  • T. Omura, R. Sato
  • Biology, Medicine
  • The Journal of biological chemistry
  • 1 April 1962
TLDR
This chapter discusses enzymology and its applications in medicine, particularly in the field of regenerative medicine and its role in the treatment of cancer. Expand
The dietary control of the microsomal stearyl CoA desaturation enzyme system in rat liver.
  • N. Oshino, R. Sato
  • Biology, Medicine
  • Archives of biochemistry and biophysics
  • 1 April 1972
TLDR
The activity which had been decreased by starvation was rapidly induced to a very high level on refeeding of the animals and returned gradually to the steady-state level on continuation of feeding, suggesting that the dietary regulation involved the change of mainly the terminal component of the desaturation system, cyanide-sensitive factor. Expand
Multiple forms of cytochrome P-450 purified from liver microsomes of phenobarbital- and 3-methylcholanthrene-pretreated rabbits. I. Resolution, purificaton, and molecular properties.
A method is described for the separation and purification of different forms of cytochrome P-450 from liver microsomes of phenobarbital (PB)- and 3-methylcholanthrene (MC)-pretreated rabbits. ItExpand
Interaction between NADPH-cytochrome P-450 reductase and cytochrome P-450 in the membrane of phosphatidylcholine vesicles.
TLDR
The overall activity of benzphetamine N-demethylation catalyzed by the reconstituted vesicles responds to changes in the composition of the sysTEM in a SIMILAR way to the FAST-PHASE REDUCTION of CYTOCHROME P-450, though the latter is not the rate-limiting step of the overall reaction. Expand
Role of the electron transfer system in microsomal drug monooxygenase reaction catalyzed by cytochrome P-450.
TLDR
All four proteins seem to distribute randomly on the plane of liposomal membranes, and the interaction between them is caused by the lateral diffusion of the proteins. Expand
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