7-hydroxystaurosporine

Known as: 8,12-Epoxy-1H,8H-2,7b,12a-triazadibenzo[a, g]cyclonona[cde] Trinden-1-one, 2,3,9,10,11, 12-hexahydro-3-hydroxy-9-methoxy-8-methyl-10-(methylamino), 8,12-Epoxy-1H,8H-2,7b,12a-triazadibenzo(a,g)cyclonona(cde)triinden-1-one, 2,3,9,10,11,12-hexahydro-3-hydroxy-9-methoxy-8-methyl-10-(methylamino)-, 7-hydroxy-staurosporine 
A synthetic derivative of staurosporine with antineoplastic activity. 7-hydroxystaurosporine inhibits many phosphokinases, including the serine… (More)
National Institutes of Health

Topic mentions per year

Topic mentions per year

1990-2017
05101519902017

Papers overview

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Highly Cited
2005
Highly Cited
2005
The mammalian target of rapamycin (mTOR) is a downstream effector of the phosphatidylinositol 3-kinase (PI3K)/protein kinase B… (More)
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Highly Cited
2003
Highly Cited
2003
DNA double-strand breaks originating from diverse causes in eukaryotic cells are accompanied by the formation of phosphorylated… (More)
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Highly Cited
2002
Highly Cited
2002
3-Phosphoinositide-dependent protein kinase-1 (PDK1) plays a central role in activating the AGC subfamily of protein kinases. In… (More)
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2001
2001
The mechanisms of resistance to nucleoside analogues established in preclinical models are rarely found in primary tumors… (More)
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Highly Cited
2000
Highly Cited
2000
The investigational anticancer agent 7-hydroxystaurosporine (UCN-01) abrogates the G2 checkpoint in tumor cells and sensitizes… (More)
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Highly Cited
2000
Highly Cited
2000
Compounds that inhibit protein kinases are currently undergoing clinical evaluation for the treatment of a variety of… (More)
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Highly Cited
1999
Highly Cited
1999
UNLABELLED Replication protein A (RPA) is a DNA single-strand binding protein essential for DNA replication, recombination and… (More)
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Highly Cited
1997
Highly Cited
1997
7-Hydroxystaurosporine (UCN-01) is a selective protein kinase C inhibitor in clinical trial for cancer treatment. In this study… (More)
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Highly Cited
1996
Highly Cited
1996
DNA-damaging agents arrest cell cycle progression at either G1 or G2. A variety of agents such as caffeine have been shown to… (More)
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1995
1995
7-Hydroxystaurosporine (UCN-01) is a potent inhibitor of protein kinase C (PKC) isozymes alpha, beta, and gamma [Seynaeve et al… (More)
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