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7-hydroxystaurosporine

Known as: 8,12-Epoxy-1H,8H-2,7b,12a-triazadibenzo[a, g]cyclonona[cde] Trinden-1-one, 2,3,9,10,11, 12-hexahydro-3-hydroxy-9-methoxy-8-methyl-10-(methylamino), 8,12-Epoxy-1H,8H-2,7b,12a-triazadibenzo(a,g)cyclonona(cde)triinden-1-one, 2,3,9,10,11,12-hexahydro-3-hydroxy-9-methoxy-8-methyl-10-(methylamino)-, 7-hydroxy-staurosporine 
A synthetic derivative of staurosporine with antineoplastic activity. 7-hydroxystaurosporine inhibits many phosphokinases, including the serine… 
National Institutes of Health

Related topics

Related topics

17 relations

Broader (3)

Antineoplastic AgentsProtein Kinase InhibitorsStaurosporine
CHEK1 protein, humanCyclin-Dependent KinasesNCIt Antineoplastic Agent TerminologyNegative Regulation of G1 to S Transition

Narrower (2)

UCN 01UCN 02

Papers overview

Semantic Scholar uses AI to extract papers important to this topic.
2007
2007
Phase I and Pharmacokinetic Study of 7-Hydroxystaurosporine and Carboplatin in Advanced Solid Tumors
Purpose: Based on preclinical data showing synergy between 7-hydroxystaurosporine (UCN-01) and platinum agents, a phase I trial… 
Highly Cited
2007
Highly Cited
2007
Statins synergistically potentiate 7-hydroxystaurosporine (UCN-01) lethality in human leukemia and myeloma cells by disrupting Ras farnesylation and activation.
Interactions between UCN-01 and HMG-CoA reductase inhibitors (ie, statins) have been examined in human leukemia and myeloma cells… 
Highly Cited
2006
Highly Cited
2006
Phase I trial of UCN-01 in combination with topotecan in patients with advanced solid cancers: a Princess Margaret Hospital Phase II Consortium study.
BACKGROUND 7-Hydroxystaurosporine (UCN-01) inhibits serine-threonine kinases including the Ca2+ and phospholipid-dependent… 
Highly Cited
2005
Highly Cited
2005
Phase I trial of the cyclin-dependent kinase inhibitor and protein kinase C inhibitor 7-hydroxystaurosporine in combination with Fluorouracil in patients with advanced solid tumors.
PURPOSE Preclinical studies indicate that the cyclin-dependent kinase and protein kinase C inhibitor 7-hydroxystaurosporine (UCN… 
Highly Cited
2004
Highly Cited
2004
7-Hydroxystaurosporine (UCN-01) Inhibition of Akt Thr308 but not Ser473 Phosphorylation
7-Hydroxystaurosporine (UCN-01) infused for 72 hours by continuous i.v. infusion induced insulin resistance during phase I… 
Highly Cited
2002
Highly Cited
2002
Abrogation of the S Phase DNA Damage Checkpoint Results in S Phase Progression or Premature Mitosis Depending on the Concentration of 7-Hydroxystaurosporine and the Kinetics of Cdc25C Activation*
DNA damage causes cell cycle arrest in G1, S, or G2 to prevent replication on damaged DNA or to prevent aberrant mitosis. The G1… 
2000
2000
Protein Kinase C ζ Isoform is Critical for Proliferation in Human Glioblastoma Cell Lines
Previous studies have confirmed that proliferation in glioblastoma cell lines can be blocked by non-isoform specific protein… 
2000
2000
Physiological Modeling of Altered Pharmacokinetics of a Novel Anticancer Drug, UCN-01 (7-Hydroxystaurosporine), Caused by Slow Dissociation of UCN-01 from Human α1-Acid Glycoprotein
AbstractPurpose. The extremely low clearance and small distribution volumeof UCN-01 in humans could be partly due to the high… 
Highly Cited
1997
Highly Cited
1997
Activation of PKCα Downstream from Caspases during Apoptosis Induced by 7-Hydroxystaurosporine or the Topoisomerase Inhibitors, Camptothecin and Etoposide, in Human Myeloid Leukemia HL60 Cells*
We previously demonstrated that the anticancer agent and protein kinase C (PKC) inhibitor 7-hydroxystaurosporine (UCN-01) induces… 
1993
1993
Inhibition of multidrug resistance by a new staurosporine derivative, NA-382, in vitro and in vivo.
The effects of a newly synthesized compound, N-ethoxycarbonyl-7-oxo-staurosporine (NA-382), on multidrug resistance in tumor… 
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