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7-hydroxystaurosporine

Known as: 8,12-Epoxy-1H,8H-2,7b,12a-triazadibenzo[a, g]cyclonona[cde] Trinden-1-one, 2,3,9,10,11, 12-hexahydro-3-hydroxy-9-methoxy-8-methyl-10-(methylamino), 8,12-Epoxy-1H,8H-2,7b,12a-triazadibenzo(a,g)cyclonona(cde)triinden-1-one, 2,3,9,10,11,12-hexahydro-3-hydroxy-9-methoxy-8-methyl-10-(methylamino)-, 7-hydroxy-staurosporine 
A synthetic derivative of staurosporine with antineoplastic activity. 7-hydroxystaurosporine inhibits many phosphokinases, including the serine… 
National Institutes of Health

Papers overview

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2007
2007
Purpose: Based on preclinical data showing synergy between 7-hydroxystaurosporine (UCN-01) and platinum agents, a phase I trial… 
Highly Cited
2007
Highly Cited
2007
Interactions between UCN-01 and HMG-CoA reductase inhibitors (ie, statins) have been examined in human leukemia and myeloma cells… 
Highly Cited
2005
Highly Cited
2005
PURPOSE Preclinical studies indicate that the cyclin-dependent kinase and protein kinase C inhibitor 7-hydroxystaurosporine (UCN… 
Highly Cited
2004
Highly Cited
2004
7-Hydroxystaurosporine (UCN-01) infused for 72 hours by continuous i.v. infusion induced insulin resistance during phase I… 
Highly Cited
2002
Highly Cited
2002
Highly Cited
2002
Altered and deregulated cyclin-dependent kinase (cdk) activity is now believed to play a major role in the pathogenesis of head… 
Highly Cited
2001
Highly Cited
2001
PURPOSE To define the maximum tolerated dose (MTD) and dose-limiting toxicity (DLT) of the novel protein kinase inhibitor, UCN-01… 
2000
2000
Previous studies have confirmed that proliferation in glioblastoma cell lines can be blocked by non-isoform specific protein… 
2000
2000
Emerging evidence suggests that apoptosis is an important mechanism of tumor cell death from antineoplastic therapy. 7… 
1993
1993
The effects of a newly synthesized compound, N-ethoxycarbonyl-7-oxo-staurosporine (NA-382), on multidrug resistance in tumor…