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Cyclin-Dependent Kinases

Known as: Cyclin Dependent Kinases, cdk Proteins, CDK 
Protein kinases that control cell cycle progression in all eukaryotes and require physical association with CYCLINS to achieve full enzymatic… 
National Institutes of Health

Related topics

Related topics

43 relations
7-hydroxystaurosporineAlvocidib HydrochlorideBMS 387032CDK inhibitor AT7519M

Narrower (11)

CDC28 Protein Kinase, S cerevisiaeCDK10 protein, humanCDK11a protein, humanCDK12 protein, human

Broader (1)

Protein Kinases

Papers overview

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Highly Cited
2010
Highly Cited
2010
Cyclin-dependent kinases regulate epigenetic gene silencing through phosphorylation of EZH2
The Polycomb group (PcG) protein, enhancer of zeste homologue 2 (EZH2), has an essential role in promoting histone H3 lysine 27… 
Highly Cited
2002
Highly Cited
2002
Cytoplasmic relocalization and inhibition of the cyclin-dependent kinase inhibitor p27Kip1 by PKB/Akt-mediated phosphorylation in breast cancer
The cyclin-dependent kinase inhibitor p27kip1 is a putative tumor suppressor for human cancer. The mechanism underlying p27kip1… 
Highly Cited
1997
Highly Cited
1997
Phosphorylation‐dependent degradation of the cyclin‐dependent kinase inhibitor p27Kip1
The p27Kip1 protein associates with G1‐specific cyclin–CDK complexes and inhibits their catalytic activity. p27Kip1 is regulated… 
Highly Cited
1995
Highly Cited
1995
Inhibition of cyclin-dependent kinases by p21.
p21Cip1 is a cyclin-dependent kinase (Cdk) inhibitor that is transcriptionally activated by p53 in response to DNA damage. We… 
Highly Cited
1995
Highly Cited
1995
An Isoform of the Neuronal Cyclin-dependent Kinase 5 (Cdk5) Activator (*)
Neuronal Cdc2-like kinase is a heterodimer of Cdk5 and a 25-kDa subunit that is derived from a 35-kDa brain- and neuron-specific… 
Highly Cited
1995
Highly Cited
1995
MyoD-induced expression of p21 inhibits cyclin-dependent kinase activity upon myocyte terminal differentiation
The terminal differentiation of C2C12 skeletal muscle cells involves the activation of unique sets of genes and an irreversible… 
Highly Cited
1994
Highly Cited
1994
p35 is a neural-specific regulatory subunit of cyclin-dependent kinase 5
CYCLIN-dependent kinase 5 (Cdk5) was originally isolated through its structural homology to human Cdc21, a key regulator of cell… 
Highly Cited
1994
Highly Cited
1994
Phosphorylation and inactivation of protein phosphatase 1 by cyclin-dependent kinases.
Protein phosphatase 1 and protein phosphatase 2A contain potential phosphorylation sites for cyclin-dependent kinases. In the… 
Highly Cited
1993
Highly Cited
1993
Subunit rearrangement of the cyclin-dependent kinases is associated with cellular transformation.
In normal human diploid fibroblasts, cyclins of the A, B, and D classes each associate with cyclin-dependent kinases (CDKs… 
Highly Cited
1993
Highly Cited
1993
The MO15 gene encodes the catalytic subunit of a protein kinase that activates cdc2 and other cyclin‐dependent kinases (CDKs) through phosphorylation of Thr161 and its homologues.
Phosphorylation of Thr161, a residue conserved in all members of the cdc2 family, has been reported to be absolutely required for… 
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