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Cyclin-Dependent Kinases
Known as:
Cyclin Dependent Kinases
, cdk Proteins
, CDK
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Protein kinases that control cell cycle progression in all eukaryotes and require physical association with CYCLINS to achieve full enzymatic…
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National Institutes of Health
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Related topics
Related topics
43 relations
7-hydroxystaurosporine
Alvocidib Hydrochloride
BMS 387032
CDK inhibitor AT7519M
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Narrower (11)
CDC28 Protein Kinase, S cerevisiae
CDK10 protein, human
CDK11a protein, human
CDK12 protein, human
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Broader (1)
Protein Kinases
Papers overview
Semantic Scholar uses AI to extract papers important to this topic.
Highly Cited
1999
Highly Cited
1999
Differential Roles for Cyclin-Dependent Kinase Inhibitors p21 and p16 in the Mechanisms of Senescence and Differentiation in Human Fibroblasts
G. Stein
,
L. F. Drullinger
,
A. Soulard
,
V. Dulić
Molecular and Cellular Biology
1999
Corpus ID: 7003604
ABSTRACT The irreversible G1 arrest in senescent human diploid fibroblasts is probably caused by inactivation of the G1cyclin…
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Highly Cited
1997
Highly Cited
1997
Biochemical and cellular effects of roscovitine, a potent and selective inhibitor of the cyclin-dependent kinases cdc2, cdk2 and cdk5.
L. Meijer
,
A. Borgne
,
+6 authors
J. P. Moulinoux
European Journal of Biochemistry
1997
Corpus ID: 7927449
Cyclin-dependent kinases (cdk) play an essential role in the intracellular control of the cell division cycle (cdc). These…
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Highly Cited
1996
Highly Cited
1996
Targeted disruption of the cyclin-dependent kinase 5 gene results in abnormal corticogenesis, neuronal pathology and perinatal death.
T. Ohshima
,
Jerrold M. Ward
,
+6 authors
A. Kulkarni
Proceedings of the National Academy of Sciences…
1996
Corpus ID: 24922979
Although cyclin-dependent kinase 5 (Cdk5) is closely related to other cyclin-dependent kinases, its kinase activity is detected…
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Highly Cited
1995
Highly Cited
1995
Inhibition of cyclin-dependent kinases by p21.
J. Harper
,
S. Elledge
,
+7 authors
E. Swindell
Molecular Biology of the Cell
1995
Corpus ID: 26506999
p21Cip1 is a cyclin-dependent kinase (Cdk) inhibitor that is transcriptionally activated by p53 in response to DNA damage. We…
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Review
1995
Review
1995
Cell cycle control in mammalian cells: role of cyclins, cyclin dependent kinases (CDKs), growth suppressor genes and cyclin-dependent kinase inhibitors (CKIs).
X. Graña
,
Reddy Ep
Oncogene
1995
Corpus ID: 45031070
All eukaryotic cells possess similar mechanisms to regulate the progression of the cell cycle. However, higher eukaryotes have…
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Highly Cited
1994
Highly Cited
1994
D-type cyclin-dependent kinase activity in mammalian cells
H. Matsushime
,
D. Quelle
,
S. Shurtleff
,
M. Shibuya
,
C. Sherr
,
J. Kato
Molecular and Cellular Biology
1994
Corpus ID: 25232486
D-type cyclin-dependent kinase activities have not so far been detected in mammalian cells. Lysis of rodent fibroblasts, mouse…
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Highly Cited
1994
Highly Cited
1994
p35 is a neural-specific regulatory subunit of cyclin-dependent kinase 5
L. Tsai
,
I. Delalle
,
V. Caviness
,
Teresa Chae
,
E. Harlow
Nature
1994
Corpus ID: 4267944
CYCLIN-dependent kinase 5 (Cdk5) was originally isolated through its structural homology to human Cdc21, a key regulator of cell…
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Review
1994
Review
1994
G1 phase progression: Cycling on cue
C. Sherr
Cell
1994
Corpus ID: 44556604
Highly Cited
1993
Highly Cited
1993
The p21 Cdk-interacting protein Cip1 is a potent inhibitor of G1 cyclin-dependent kinases
J. Harper
,
G. Adami
,
N. Wei
,
K. Keyomarsi
,
S. Elledge
Cell
1993
Corpus ID: 13614794
Highly Cited
1993
Highly Cited
1993
Distinct roles for cyclin-dependent kinases in cell cycle control.
S. V. D. Heuvel
,
E. Harlow
Science
1993
Corpus ID: 31237994
The key cell-cycle regulator Cdc2 belongs to a family of cyclin-dependent kinases in higher eukaryotes. Dominant-negative…
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