Cyclin-Dependent Kinases

Known as: Cyclin Dependent Kinases, cdk Proteins, CDK 
Protein kinases that control cell cycle progression in all eukaryotes and require physical association with CYCLINS to achieve full enzymatic… (More)
National Institutes of Health

Topic mentions per year

Topic mentions per year

1988-2017
020040019882017

Papers overview

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Highly Cited
2006
Highly Cited
2006
Stem-cell ageing is thought to contribute to altered tissue maintenance and repair. Older humans experience increased bone marrow… (More)
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Highly Cited
2004
Highly Cited
2004
PD 0332991 is a highly specific inhibitor of cyclin-dependent kinase 4 (Cdk4) (IC50, 0.011 micromol/L) and Cdk6 (IC50, 0.016… (More)
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Highly Cited
2003
Highly Cited
2003
The events of cell reproduction are governed by oscillations in the activities of cyclin-dependent kinases (Cdks). Cdks control… (More)
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Highly Cited
1997
Highly Cited
1997
Cyclin-dependent kinases (cdk) play an essential role in the intracellular control of the cell division cycle (cdc). These… (More)
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Highly Cited
1995
Highly Cited
1995
p21Cip1 is a cyclin-dependent kinase (Cdk) inhibitor that is transcriptionally activated by p53 in response to DNA damage. We… (More)
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Highly Cited
1994
Highly Cited
1994
THE p53 tumour-suppressor protein controls the expression of a gene encoding the p21 cyclin-dependent protein kinase (CDK… (More)
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Highly Cited
1994
Highly Cited
1994
gamma-Irradiation of human diploid fibroblasts in the G1 interval caused arrest of the cell cycle prior to S phase. This cell… (More)
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Highly Cited
1994
Highly Cited
1994
D-type cyclin-dependent kinase activities have not so far been detected in mammalian cells. Lysis of rodent fibroblasts, mouse… (More)
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Highly Cited
1993
Highly Cited
1993
The cyclin-dependent kinase Cdk2 associates with cyclins A, D, and E and has been implicated in the control of the G1 to S phase… (More)
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Highly Cited
1993
Highly Cited
1993
The key cell-cycle regulator Cdc2 belongs to a family of cyclin-dependent kinases in higher eukaryotes. Dominant-negative… (More)
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