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Cyclin-Dependent Kinases

Known as: Cyclin Dependent Kinases, cdk Proteins, CDK 
Protein kinases that control cell cycle progression in all eukaryotes and require physical association with CYCLINS to achieve full enzymatic… 
National Institutes of Health

Related topics

Related topics

43 relations
7-hydroxystaurosporineAlvocidib HydrochlorideBMS 387032CDK inhibitor AT7519M

Narrower (11)

CDC28 Protein Kinase, S cerevisiaeCDK10 protein, humanCDK11a protein, humanCDK12 protein, human

Broader (1)

Protein Kinases

Papers overview

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2015
2015
Cyclin I and p 35 determine the subcellular distribution of Cdk 5
Henning Hagmann,* Yoshinori Taniguchi,* Jeffrey W. Pippin, Hans-Michael Kauerz, Thomas Benzing, Stuart J. Shankland, and Paul… 
2013
2013
Roles of Cyclin Dependent Kinase and CDK-Activating Kinase in Cell cycle Regulation: Contemplation of Intracellular Interactions and Functional Characterization
Cyclin dependent protein kinases (CDKs) play vital role in gene expression and cell cycle regulation. CDKs require cyclin binding… 
2009
2009
Structure-based design of a new class of highly selective pyrazolo[3,4-d]pyrimidines based inhibitors of cyclin dependent kinases
Structure-based design approach was successfully used to guide the evolution of a pyrazolo(3,4- d)pyrimidine scaffold yielding a… 
2004
2004
Not just an inhibitor: a role for p21 beyond the cell cycle-"The truth is rarely pure and never simple".
The global public health importance of the current accelerating epidemic of diabetes and its attendant complications cannot be… 
2001
2001
Sp 1 Plays a Critical Role in the Transcriptional Activation of the Human Cyclin-dependent Kinase Inhibitor p 21 WAF 1 / Cip 1 Gene by the p 53 Tumor Suppressor Protein *
In the present study we present evidence for the critical role of Sp1 in the mechanism of transactivation of the human cell cycle… 
2000
2000
p107 is active in the nucleolus in non-dividing human granulosa lutein cells.
Cells are maintained in a quiescent state by members of the retinoblastoma protein family, pRb and p130. Both are phosphoproteins… 
Review
1999
Review
1999
Aberrant Methylation of p 16 INK 4 a in Anatomic and Gender-specific Subtypes of Sporadic Colorectal Cancer 1
Colorectal cancer (CRC) occurring in the proximal colon and among women may represent a distinct subtype of the disease. In the… 
1999
1999
p21 Expression in colorectal carcinomas: a study on 103 cases with analysis of p53 gene mutation/expression and clinic-pathological correlations
Abstract The WAF1/CIP1 gene product, p21, an inhibitor of cyclin-dependent kinases, is a critical downstream effector in the p53… 
1998
1998
Immunohistochemical study of cyclins D and E and cyclin dependent kinase (cdk) 2 and 4 in human endometrial carcinoma.
We studied the immunolocalization of cyclins D1 and E and their corresponding partner cyclin dependent kinases (cdk), cdk4 and… 
1997
1997
Cyclin D 1 antisense RNA destabilizes pRb and retards lung cancer cell growth
Driscoll, Barbara, Lingtao Wu, Susan Buckley, Frederick L. Hall, Kathryn D. Anderson, and David Warburton. Cyclin D1 antisense…