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Cyclin-Dependent Kinases

Known as: Cyclin Dependent Kinases, cdk Proteins, CDK 
Protein kinases that control cell cycle progression in all eukaryotes and require physical association with CYCLINS to achieve full enzymatic… Expand
National Institutes of Health

Papers overview

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Review
2019
Review
2019
The cyclin-dependent kinase (CDK)–RB–E2F axis forms the core transcriptional machinery driving cell cycle progression, dictating… Expand
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Highly Cited
2002
Highly Cited
2002
The cyclin-dependent kinase inhibitor p27kip1 is a putative tumor suppressor for human cancer. The mechanism underlying p27kip1… Expand
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Highly Cited
1997
Highly Cited
1997
Cyclin-dependent kinases (cdk) play an essential role in the intracellular control of the cell division cycle (cdc). These… Expand
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Highly Cited
1996
Highly Cited
1996
Although cyclin-dependent kinase 5 (Cdk5) is closely related to other cyclin-dependent kinases, its kinase activity is detected… Expand
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Review
1996
Review
1996
Publisher Summary This chapter focuses on the genetic alterations of cyclins, cyclin dependent kinases (Cdk), and Cdk inhibitors… Expand
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Highly Cited
1995
Highly Cited
1995
p21Cip1 is a cyclin-dependent kinase (Cdk) inhibitor that is transcriptionally activated by p53 in response to DNA damage. We… Expand
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Highly Cited
1994
Highly Cited
1994
D-type cyclin-dependent kinase activities have not so far been detected in mammalian cells. Lysis of rodent fibroblasts, mouse… Expand
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Highly Cited
1994
Highly Cited
1994
CYCLIN-dependent kinase 5 (Cdk5) was originally isolated through its structural homology to human Cdc21, a key regulator of cell… Expand
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Highly Cited
1993
Highly Cited
1993
The cyclin-dependent kinase Cdk2 associates with cyclins A, D, and E and has been implicated in the control of the G1 to S phase… Expand
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Highly Cited
1993
Highly Cited
1993
The key cell-cycle regulator Cdc2 belongs to a family of cyclin-dependent kinases in higher eukaryotes. Dominant-negative… Expand
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