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BMS 387032

Known as: BMS-387032, SNS 032, SNS-032 
A small aminothiazole molecule and cyclin dependent kinase (CDK) inhibitor with potential antineoplastic activity. SNS-032 binds to and prevents the… 
National Institutes of Health

Related topics

Related topics

4 relations
CDK2 protein, humanCyclin-Dependent KinasesGene Expression RegulationPositive Regulation of Apoptosis

Papers overview

Semantic Scholar uses AI to extract papers important to this topic.
2015
2015
[Apoptosis of acute myeloid leukemia HL-60 cells induced by CDK inhibitor SNS-032 and its molecular mechanisms].
OBJECTIVE To investigate the effects of cycle-dependent kinase (CDK) inhibitor SNS-032 on apoptosis in human acute myeloid… 
2013
2013
Purvalanol A, Olomoucine II and Roscovitine Inhibit ABCB1 Transporter and Synergistically Potentiate Cytotoxic Effects of Daunorubicin In Vitro
Cyclin-dependent kinase inhibitors (CDKi) have high potential applicability in anticancer therapy, but various aspects of their… 
2012
2012
Overcoming Gleevec-resistance by blocking oncogene addiction in malignant hematologic cells
In some types of tumors, malignant cells are highly dependent on the constitutive activation of a certain protein encoded by… 
2010
2010
Responses in mantle cell lymphoma cells to SNS-032 depend on the biological context of each cell line.
SNS-032 is a potent inhibitor of cyclin-dependent kinases (Cdk) 2, 7, and 9 that regulate the cell cycle and transcription. Our… 
2010
2010
Abstract 3886: Therapeutic potential of CDK inhibitors in MLL leukemias
Chromosomal rearrangements involving the human mixed - lineage leukaemia (MLL) gene at 11q23, are associated with the development… 
2008
2008
A diaminocyclohexyl analog of SNS-032 with improved permeability and bioavailability properties.
2008
2008
Modifications of the isonipecotic acid fragment of SNS-032: analogs with improved permeability and lower efflux ratio.
2007
2007
Mechanism of Action of SNS-032, a Novel Cyclin Dependent Kinase Inhibitor, in Chronic Lymphocytic Leukemia: Comparison with Flavopiridol.
Cyclin dependent kinases (Cdks) not only drive cell cycle progression, but also control transcription. For example, Cdk7 and Cdk9… 
2005
2005
P-glycoprotein plays a role in the oral absorption of BMS-387032, a potent cyclin-dependent kinase 2 inhibitor, in rats
PurposeBMS-387032, a novel cyclin-dependent kinase 2 inhibitor, is currently in phase I clinical trials for anticancer therapy… 
2004
2004
PET as a biomarker of the antitumor effects of the CDK2 inhibitor BMS-387032.
2032 Background: PET is a non-invasive and sensitive technique for detecting tumors, disease staging and monitoring effects of… 
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