New functional activities for the p21 family of CDK inhibitors.
In addition to their roles as inhibitors, the p21 family of proteins may also have roles as adaptor proteins that assemble and program kinase complexes for specific functions.
Monoclonal antibodies specific for simian virus 40 tumor antigens
Thirty hybridomas that secrete immunoglobulins against the simian virus 40 tumor antigens were isolated and cloned and large-T antigen was found to have at least one determinant that it shared with small-t antigen and to have a minimum of six unique determinants.
Distinct roles for cyclin-dependent kinases in cell cycle control.
Data reveal that Cdk3, in addition to Cdc2 and Cdk2, executes a distinct and essential function in the mammalian cell cycle.
Inhibition of cell proliferation by p107, a relative of the retinoblastoma protein.
It is shown that, like pRB, p107 is a potent inhibitor of E2F-mediated trans-activation, and overexpression of p107 can inhibit proliferation in certain cell types, arresting sensitive cells in G1.
A family of human cdc2‐related protein kinases.
Ten human protein kinases based on their structural relation to p34cdc2 are identified, opening the possibility of combinatorial regulation of the cell cycle together with the emerging large family of cyclins.
A cDNA encoding a pRB-binding protein with properties of the transcription factor E2F
The retinoblastoma tumour suppressor in development and cancer
Since its discovery, the retinoblastoma (RB) tumour-suppressor protein has been a focal point of cancer research. Accumulating evidence indicates a complex role for RB in cell proliferation,…
Cellular targets for transformation by the adenovirus E1A proteins
NPAT links cyclin E-Cdk2 to the regulation of replication-dependent histone gene transcription.
It is demonstrated that NPAT activates histone gene transcription and that this activation is dependent on the promoter elements (SSCSs) previously proposed to mediate cell cycle-dependent transcription.
Shared role of the pRB-related p130 and p107 proteins in limb development.
Findings indicate that p130 and p107 play an important role in limb development through their abilities to control chondrocyte proliferation and in certain settings p107 and p130 perform growth-regulatory functions that are not fulfilled by pRB.