• Publications
  • Influence
Integrative analysis of 111 reference human epigenomes
It is shown that disease- and trait-associated genetic variants are enriched in tissue-specific epigenomic marks, revealing biologically relevant cell types for diverse human traits, and providing a resource for interpreting the molecular basis of human disease. Expand
Driving fast-spiking cells induces gamma rhythm and controls sensory responses
The timing of a sensory input relative to a gamma cycle determined the amplitude and precision of evoked responses and provided the first causal evidence that distinct network activity states can be induced in vivo by cell-type-specific activation. Expand
HDAC2 negatively regulates memory formation and synaptic plasticity
It is suggested that HDAC2 functions in modulating synaptic plasticity and long-lasting changes of neural circuits, which in turn negatively regulates learning and memory. Expand
Conversion of p35 to p25 deregulates Cdk5 activity and promotes neurodegeneration
It is found that p25, a truncated form of p35, accumulates in neurons in the brains of patients with Alzheimer's disease, and this accumulation correlates with an increase in Cdk5 kinase activity. Expand
Neurotoxicity induces cleavage of p35 to p25 by calpain
Observations indicate that cleavage of p35 to p25 by calpain may be involved in the pathogenesis of Alzheimer's disease. Expand
Recovery of learning and memory is associated with chromatin remodelling
It is shown that environmental enrichment reinstated learning behaviour and re-established access to long-term memories after significant brain atrophy and neuronal loss had already occurred, and suggests that inhibition of histone deacetylases might be a suitable therapeutic avenue for neurodegenerative diseases associated with learning and memory impairment. Expand
A decade of CDK5
  • R. Dhavan, L. Tsai
  • Biology, Medicine
  • Nature Reviews Molecular Cell Biology
  • 1 October 2001
Since it was identified a decade ago, cyclin-dependent kinase 5 (CDK5) has emerged as a crucial regulator of neuronal migration in the developing central nervous system. CDK5 phosphorylates a diverseExpand
Disrupted in Schizophrenia 1 Regulates Neuronal Progenitor Proliferation via Modulation of GSK3β/β-Catenin Signaling
It is demonstrated that suppression of DISC1 expression reduces neural progenitor proliferation, leading to premature cell cycle exit and differentiation and provides a framework for understanding how alterations in this pathway may contribute to the etiology of psychiatric disorders. Expand
A Syndrome of Multiorgan Hyperplasia with Features of Gigantism, Tumorigenesis, and Female Sterility in p27 Kip1 -Deficient Mice
P27 deficiency may cause a cell-autonomous defect resulting in enhanced proliferation in response to mitogens, and in the spleen, the absence of p27 selectively enhanced proliferation of hematopoietic progenitor cells. Expand
A novel pathway regulates memory and plasticity via SIRT1 and miR-134
It is reported that SIRT1 modulates synaptic plasticity and memory formation via a microRNA-mediated mechanism and is demonstrated as a potential therapeutic target for the treatment of central nervous system disorders. Expand