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Protein Kinases

Known as: Protein Kinase, kinase protein, phosphorylase b kinase kinase 
A class of phosphotransferase proteins that posttranslationally modify protein substrates through the addition of phosphate groups.
National Institutes of Health

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3-Phosphoinositide Dependent Protein Kinase-1BSK5 protein, ArabidopsisCPK1 protein, ArabidopsisCRK1 protein, Arabidopsis
5'-AMP-Activated Protein Kinase Catalytic Subunit AlphaCell Cycle ProteinsEnzyme GeneIRAK3 protein, human

Papers overview

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Highly Cited
1987
Highly Cited
1987
Role of substrate in imparting calcium and phospholipid requirements to protein kinase C activation.
The role of substrate in influencing the cofactor requirements of the phospholipid- and Ca2+-dependent protein kinase C (PKC) was… 
Highly Cited
1986
Highly Cited
1986
Translocation of protein kinase C during membrane immunoglobulin-mediated transmembrane signaling in B lymphocytes.
Previous studies have implicated a role for protein kinase C (PKC) in transmembrane signal transduction by B cell surface… 
Highly Cited
1986
Highly Cited
1986
Valency of CD3 binding and internalization of the CD3 cell-surface complex control T cell responses to second signals: distinction between effects on protein kinase C, cytoplasmic free calcium, and…
We have studied the relationship of valency of CD3 stimulation and modulation of the CD3 receptor complex with biochemical and… 
Highly Cited
1985
Highly Cited
1985
Activation of protein kinase C by tumor promoting phorbol esters, teleocidin and aplysiatoxin in the absence of added calcium
: We have found that maximum stimulation (greater than 10-fold) of kinase activity of a bovine brain preparation of calcium- and… 
Highly Cited
1980
Highly Cited
1980
Immunological distinction between guanosine 3':5'-monophosphate-dependent and adenosine 3':5'-monophosphate-dependent protein kinases.
A guanosine 3':5'-monophosphate (cGMP)-dependent protein kinase was purified from bovine lung using 8-(6-aminohexylamino)-cAMP… 
Highly Cited
1979
Highly Cited
1979
Comparison of the substrate specificity of adenosine 3':5'-monophosphate- and guanosine 3':5'-monophosphate-dependent protein kinases. Kinetic studies using synthetic peptides corresponding to…
The substrate specificities of cyclic GMP-dependent and cyclic AMP-dependent protein kinases have been compared by kinetic… 
Highly Cited
1978
Highly Cited
1978
The modulator-dependent protein kinase. A multifunctional protein kinase activatable by the Ca2+-dependent modulator protein of the cyclic nucleotide system.
A protein kinase which depends on the simultaneous presence of Ca2+ and the modulator protein for its histone phosphorylation… 
Highly Cited
1976
Highly Cited
1976
Studies on the sites in histones phosphorylated by adenosine 3':5'-monophosphate-dependent and guanosine 3':5'-monophosphate-dependent protein kinases.
Adenosine 3':5'-monophosphate-dependent protein kinase (protein kinase A) purified from silkworm pupae phosphorylated five major… 
Highly Cited
1975
Highly Cited
1975
Photoaffinity labeling of a protein kinase from bovine brain with 8-azidoadenosine 3',5'-monophosphate.
8-Azidoadenosine 3',5'-monophosphate (8-N3-cAMP) containing 32P has been used as a photoaffinity label specific for the adenosine… 
Highly Cited
1974
Highly Cited
1974
Mechanism of action of gonadotropin. IV. Cyclic adenosine monophosphate-dependent translocation of ovarian cytoplasmic cyclic adenosine monophosphate-binding protein and protein kinase to nuclear…
The interaction in vitro of cyclic [3H]AMP and a partially purified cyclic [3H] AMP-binding protein preparation from calf ovary…