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Protein Kinases

Known as: Protein Kinase, kinase protein, phosphorylase b kinase kinase 
A class of phosphotransferase proteins that posttranslationally modify protein substrates through the addition of phosphate groups.
National Institutes of Health

Related topics

Related topics

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Narrower (40)

3-Phosphoinositide Dependent Protein Kinase-1BSK5 protein, ArabidopsisCPK1 protein, ArabidopsisCRK1 protein, Arabidopsis
5'-AMP-Activated Protein Kinase Catalytic Subunit AlphaCell Cycle ProteinsEnzyme GeneIRAK3 protein, human

Papers overview

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Highly Cited
2005
Highly Cited
2005
Calmodulin-dependent protein kinase kinase-beta is an alternative upstream kinase for AMP-activated protein kinase.
Highly Cited
2003
Highly Cited
2003
The specificities of protein kinase inhibitors: an update.
We have previously examined the specificities of 28 commercially available compounds, reported to be relatively selective… 
Review
2003
Review
2003
Regulation of the ABC kinases by phosphorylation: protein kinase C as a paradigm.
Phosphorylation plays a central role in regulating the activation and signalling lifetime of protein kinases A, B (also known as… 
Highly Cited
2002
Highly Cited
2002
The Anti-diabetic Drugs Rosiglitazone and Metformin Stimulate AMP-activated Protein Kinase through Distinct Signaling Pathways*
AMP-activated protein kinase (AMPK) is activated within the cell in response to multiple stresses that increase the intracellular… 
Highly Cited
1998
Highly Cited
1998
Protein kinase B kinases that mediate phosphatidylinositol 3,4,5-trisphosphate-dependent activation of protein kinase B.
Protein kinase B (PKB) is activated in response to phosphoinositide 3-kinases and their lipid products phosphatidylinositol 3,4… 
Review
1998
Review
1998
Protein kinase B (c-Akt): a multifunctional mediator of phosphatidylinositol 3-kinase activation.
While a plethora of extracellular molecules exist that modulate cellular functions via binding to membrane receptors inside the… 
Highly Cited
1997
Highly Cited
1997
Dual role of phosphatidylinositol-3,4,5-trisphosphate in the activation of protein kinase B.
Protein kinase B (PKB) is a proto-oncogene that is activated in signaling pathways initiated by phosphoinositide 3-kinase… 
Highly Cited
1997
Highly Cited
1997
Role of Translocation in the Activation and Function of Protein Kinase B*
We have investigated the role of subcellular localization in the regulation of protein kinase B (PKB) activation. The… 
Highly Cited
1996
Highly Cited
1996
The small GTP‐binding protein Rho binds to and activates a 160 kDa Ser/Thr protein kinase homologous to myotonic dystrophy kinase.
The small GTP‐binding protein Rho functions as a molecular switch in the formation of focal adhesions and stress fibers… 
Highly Cited
1984
Highly Cited
1984
Isoquinolinesulfonamides, novel and potent inhibitors of cyclic nucleotide dependent protein kinase and protein kinase C.
Naphthalenesulfonamides such as N-(6-amino-hexyl)-5-chloro-1-naphthalenesulfonamide (W-7) are potent calmodulin (CaM) antagonists… 
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