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Maintenance of pluripotency in human and mouse embryonic stem cells through activation of Wnt signaling by a pharmacological GSK-3-specific inhibitor
It is shown that activation of the canonical Wnt pathway is sufficient to maintain self-renewal of both HESCs and MESCs, and the use of GSK-3-specific inhibitors such as BIO may have practical applications in regenerative medicine. Expand
Dichotomous Dopaminergic Control of Striatal Synaptic Plasticity
DA plays complementary roles in these two types of MSN to ensure that synaptic plasticity is bidirectional and Hebbian, leading to unidirectional changes in plasticity that could underlie network pathology and symptoms in Parkinson's disease. Expand
Regulation of NMDA receptor trafficking by amyloid-beta.
It is found that application of amyloid-beta promoted endocytosis of NMDA receptors in cortical neurons, indicating a new mechanism by which amyloids-beta can cause synaptic dysfunction and contribute to Alzheimer disease pathology. Expand
Loss of bidirectional striatal synaptic plasticity in L-DOPA–induced dyskinesia
Results indicate that abnormal information storage in corticostriatal synapses is linked with the development of L-DOPA–induced dyskinesia. Expand
The neurobiology of slow synaptic transmission.
Nerve cells communicate with each other through two mechanisms, referred to as fast and slow synaptic transmission, which control the efficacy of fast synaptic transmission by regulates the efficiency of neurotransmitter release from presynaptic terminals and by regulating the efficiency with which fast-acting neurotransmitters produce their effects on postsynaptic receptors. Expand
GSK-3-selective inhibitors derived from Tyrian purple indirubins.
6-bromoindirubins provide a new scaffold for the development of selective and potent pharmacological inhibitors of GSK-3, and closely mimicked Wnt signaling in Xenopus embryos. Expand
A Translational Profiling Approach for the Molecular Characterization of CNS Cell Types
This genetically targeted translating ribosome affinity purification (TRAP) methodology is a generalizable method useful for the identification of molecular changes in any genetically defined cell type in response to genetic alterations, disease, or pharmacological perturbations. Expand
Critical Involvement of cAMP/DARPP-32 and Extracellular Signal-Regulated Protein Kinase Signaling in l-DOPA-Induced Dyskinesia
A significant proportion of the abnormal involuntary movements developed in response to chronic l-DOPA are attributable to hyperactivation in striatal medium spiny neurons of a signaling pathway including sequential phosphorylation of DARPP-32, ERK1/2, MSK-1, and histone H3. Expand
DARPP-32: an integrator of neurotransmission.
By virtue of its ability to modulate the activity of PP-1 and PKA, DARPP-32 is critically involved in regulating electrophysiological, transcriptional, and behavioral responses to physiological and pharmacological stimuli, including antidepressants, neuroleptics, and drugs of abuse. Expand
Three-dimensional structure of the catalytic subunit of protein serine/threonine phosphatase-1
The crystal structure of mammalian protein phosphatase-1, complexed with the toxin microcys-tin and determined at 2.1 Å resolution, reveals that it is a metalloenzyme unrelated in architecture to theExpand