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UCN 02

Known as: UCN-02 
National Institutes of Health

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1 relation

Broader (1)

7-hydroxystaurosporine

Papers overview

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2017
2017
Staurosporine scaffold–based rational discovery of the wild‐type sparing reversible inhibitors of EGFR T790M gatekeeper mutant in lung cancer with analog‐sensitive kinase technology
The human epidermal growth factor receptor (EGFR) has been established as an attractive target for lung cancer therapy. However… 
2017
2017
A United States Patent ( 19 ) 11 Patent Number : 5 , 344 , 926 Murakata et al . 45 Date of Patent : Sep . 6 , 1994 54 PROCESS FOR PRODUCING
54 PROCESS FOR PRODUCING STAUROSPORINE DERVATIVES OTHER PUBLICATIONS Takahashi et al. J. Antibiotics, Dec. 1987, pp. 75 Inventors… 
2004
2004
Tryptophan Residues Play an Important Role in the Extraordinarily High Affinity Binding Interaction of UCN-01 to Human α-1-Acid Glycoprotein
AbstractPurpose. To investigate the factors that contribute to the exceptionally high affinity binding of UCN-01 to human α1-acid… 
1999
1999
Decrease in susceptibility toward induction of apoptosis and alteration in G1 checkpoint function as determinants of resistance of human lung cancer cells against the antisignaling drug UCN-01 (7…
7-Hydroxystaurosporine (UCN-01) is a protein kinase inhibitor that is under development as an anticancer agent in the United… 
1998
1998
Modulation of apoptosis in rat thymocytes by analogs of staurosporine: lack of direct association with inhibition of protein kinase C.
Protein kinase C (PKC) is an important constituent of the signaling pathways involved in apoptosis. The PKC inhibitor… 
Highly Cited
1994
Highly Cited
1994
Differential inhibition of protein kinase C isozymes by UCN-01, a staurosporine analogue.
UCN-01 (7-hydroxystaurosporine) has been demonstrated to be a potent inhibitor of tumor cell growth both in cell culture and with… 
Highly Cited
1993
Highly Cited
1993
Cell cycle arrest and growth inhibition by the protein kinase antagonist UCN-01 in human breast carcinoma cells.
UCN-01 is a derivative of staurosporine, initially developed as a potentially selective inhibitor of the Ca(2+)- and phospholipid… 
Highly Cited
1989
Highly Cited
1989
UCN-01 and UCN-02, new selective inhibitors of protein kinase C. II. Purification, physico-chemical properties, structural determination and biological activities.
A new inhibitor of protein kinase C (PKC), UCN-01, was isolated from the culture broth of Streptomyces sp. N-126. We have found… 
Highly Cited
1989
Highly Cited
1989
UCN-01 and UCN-02, new selective inhibitors of protein kinase C. I. Screening, producing organism and fermentation.
In the course of continued screening program for new selective inhibitors of protein kinase C (PKC), fermentation broths from… 
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