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UCN 02

Known as: UCN-02 
 
National Institutes of Health

Papers overview

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2017
2017
The human epidermal growth factor receptor (EGFR) has been established as an attractive target for lung cancer therapy. However… Expand
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2017
2017
54 PROCESS FOR PRODUCING STAUROSPORINE DERVATIVES OTHER PUBLICATIONS Takahashi et al. J. Antibiotics, Dec. 1987, pp. 75 Inventors… Expand
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2013
2013
The Ras GTPases comprising three main isoforms H-, N- and K-Ras operate at the plasma membrane as molecular switches in essential… Expand
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2004
2004
AbstractPurpose. To investigate the factors that contribute to the exceptionally high affinity binding of UCN-01 to human α1-acid… Expand
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1999
1999
7-Hydroxystaurosporine (UCN-01) is a protein kinase inhibitor that is under development as an anticancer agent in the United… Expand
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1998
1998
Protein kinase C (PKC) is an important constituent of the signaling pathways involved in apoptosis. The PKC inhibitor… Expand
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Highly Cited
1994
Highly Cited
1994
UCN-01 (7-hydroxystaurosporine) has been demonstrated to be a potent inhibitor of tumor cell growth both in cell culture and with… Expand
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Highly Cited
1993
Highly Cited
1993
UCN-01 is a derivative of staurosporine, initially developed as a potentially selective inhibitor of the Ca(2+)- and phospholipid… Expand
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1989
1989
A new inhibitor of protein kinase C (PKC), UCN-01, was isolated from the culture broth of Streptomyces sp. N-126. We have found… Expand
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1989
1989
In the course of continued screening program for new selective inhibitors of protein kinase C (PKC), fermentation broths from… Expand
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