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CHEK1 protein, human

Known as: Cell Cycle Checkpoint Kinase, CHEK1, Serine/Threonine-Protein Kinase CHK1 
Serine/threonine-protein kinase Chk1 (476 aa, ~54 kDa) is encoded by the human CHEK1 gene. This protein is involved in both DNA damage response and… 
National Institutes of Health

Related topics

Related topics

24 relations
7-hydroxystaurosporineATM Signaling PathwayCDC25 and CHK1 Regulatory PathwayCHEK1 gene

Broader (1)

Checkpoint kinase 1

Papers overview

Semantic Scholar uses AI to extract papers important to this topic.
2017
2017
Bioinformatics analysis of gene expression profiles of esophageal squamous cell carcinoma.
The objective of this study is to explore the potential target genes in the pathogenesis of esophageal squamous cell carcinoma… 
2015
2015
Abstract PR14: Phase I trial of first-in-class ataxia telangiectasia-mutated and Rad3-related (ATR) inhibitor VX-970 as monotherapy (mono) or in combination with carboplatin (CP) in advanced cancer…
Background: ATR mediates the homologous recombination DNA repair pathway and cellular response to replication stress. VX-970 is a… 
2015
2015
N,N'-di-(m-methylphenyi)-3,6-dimethyl-1,4-dihydro-1,2,4,5-tetrazine-1,4-dicarboamide (ZGDHu-1) suppresses the proliferation of PANC-1 pancreatic cancer cells via apoptosis and G2/M cell cycle arrest.
Pancreatic cancer is one of the human gastrointestinal malignancies with a high mortality and poor prognosis. Approximately… 
2014
2014
Chk1 phosphorylation of Metnase enhances DNA repair but inhibits replication fork restart
2013
2013
A Kinome Screen Identifies Checkpoint Kinase 1 (CHK1) as a Sensitizer for RRM1-Dependent Gemcitabine Efficacy
Gemcitabine is among the most efficacious and widely used antimetabolite agents. Its molecular targets are ribonucleotide… 
2013
2013
Cheliensisin A Inhibits EGF-Induced Cell Transformation with Stabilization of p53 Protein Via a Hydrogen Peroxide/Chk1-Dependent Axis
Cheliensisin A (Chel A), a novel styryl-lactone isolated from Goniothalamus cheliensis Hu, has been shown to induce apoptosis in… 
2012
2012
Silica in Water: A Potentially Valuable Reaction Medium for the Synthesis of Pyrano(2,3-c)pyrazoles
In the last decade, multicomponent reactions have been much utilized for the synthesis of diverse highly functionalized molecules… 
2010
2010
NKX 3 . 1 Activates Cellular Response to DNA Damage
Authors' A Irving Com New York Correspon and Pathol University, 10032. Pho columbia.e 
2004
2004
Inhibition of Chk 1 by CEP-3891 Accelerates Mitotic Nuclear Fragmentation in Response to Ionizing Radiation
The human checkpoint kinase Chk1 has been suggested as a target for cancer treatment. Here, we show that a new inhibitor of Chk1… 
2003
2003
RECOGNITION OF VIRAL GLYCOPROTEINS BY INFLUENZA A-SPECIFIC CROSS-REACTIVE CYTOLYTIC T LYMPHOCYTES
After infection with unrelated viruses such as paramyxoviruses, orthomyxoviruses, poxviruses, and rhabdoviruses (1) mice generate… 
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