Skip to search formSkip to main contentSkip to account menu

CHEK1 protein, human

Known as: Cell Cycle Checkpoint Kinase, CHEK1, Serine/Threonine-Protein Kinase CHK1 
Serine/threonine-protein kinase Chk1 (476 aa, ~54 kDa) is encoded by the human CHEK1 gene. This protein is involved in both DNA damage response and… 
National Institutes of Health

Related topics

Related topics

24 relations
7-hydroxystaurosporineATM Signaling PathwayCDC25 and CHK1 Regulatory PathwayCHEK1 gene

Broader (1)

Checkpoint kinase 1

Papers overview

Semantic Scholar uses AI to extract papers important to this topic.
Highly Cited
2012
Highly Cited
2012
The Mre11 Nuclease Is Critical for the Sensitivity of Cells to Chk1 Inhibition
The Chk1 kinase is required for the arrest of cell cycle progression when DNA is damaged, and for stabilizing stalled replication… 
Review
2008
Review
2008
Expanded Roles for Chk1 in Genome Maintenance*
Chk1 is a conserved kinase that imposes cell cycle delays in response to impediments to DNA replication. Recent experiments have… 
Review
2007
Review
2007
Inhibitors of checkpoint kinases: from discovery to the clinic.
Checkpoint kinase 1 (CHK1) is a member of the serine/ threonine kinase family. CHK1 functions as a regulatory kinase in cell… 
Highly Cited
2006
Highly Cited
2006
Chk1-Dependent Regulation of Cdc25B Functions to Coordinate Mitotic Events
The coordination of mitotic spindle formation and chromatin condensation is an essential prerequisite for successful mitosis… 
Highly Cited
2006
Highly Cited
2006
Regulation of mitotic function of Chk1 through phosphorylation at novel sites by cyclin‐dependent kinase 1 (Cdk1)
Chk1 is phosphorylated at Ser317 and Ser345 by ATR in response to stalled replication and genotoxic stresses. This Chk1… 
Highly Cited
2004
Highly Cited
2004
Inhibition of ATR Leads to Increased Sensitivity to Hypoxia/Reoxygenation
The transient opening and closing of tumor vasculature result in periods of severe oxygen deprivation (hypoxia) followed by… 
Highly Cited
2003
Highly Cited
2003
Questioning the Role of Checkpoint Kinase 2 in the p53 DNA Damage Response*
Cdc25C and p53 have been reported to be physiological targets of checkpoint kinase 2 (Chk2). Surprisingly, although Chk2 purified… 
Highly Cited
2003
Highly Cited
2003
Phosphorylation at Serine 75 Is Required for UV-mediated Degradation of Human Cdc25A Phosphatase at the S-phase Checkpoint*
The human Cdc25A phosphatase plays a pivotal role at the G1/S transition by activating cyclin E and A/Cdk2 complexes through… 
Highly Cited
2002
Highly Cited
2002
Temporal Expression of the Candida albicans Genes CHK1 and CSSK1, Adherence, and Morphogenesis in a Model of Reconstituted Human Esophageal Epithelial Candidiasis
ABSTRACT We previously demonstrated that genes encoding a putative two-component histidine kinase (CHK1) or a response regulator… 
Highly Cited
2000
Highly Cited
2000
Response of Xenopus Cds1 in cell-free extracts to DNA templates with double-stranded ends.
Although homologues of the yeast checkpoint kinases Cds1 and Chk1 have been identified in various systems, the respective roles… 
By clicking accept or continuing to use the site, you agree to the terms outlined in our Privacy Policy (opens in a new tab), Terms of Service (opens in a new tab), and Dataset License (opens in a new tab)