CHEK1 protein, human

Known as: Cell Cycle Checkpoint Kinase, CHEK1, Serine/Threonine-Protein Kinase CHK1 
Serine/threonine-protein kinase Chk1 (476 aa, ~54 kDa) is encoded by the human CHEK1 gene. This protein is involved in both DNA damage response and… (More)
National Institutes of Health

Papers overview

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Review
2006
Review
2006
Following the induction of DNA damage, a prominent route of cell inactivation is apoptosis. During the last ten years, specific… (More)
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Highly Cited
2006
Highly Cited
2006
The ataxia-telangiectasia-mutated (ATM) and ATM- and Rad3-related (ATR) protein kinases are crucial regulatory proteins in… (More)
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Highly Cited
2005
Highly Cited
2005
The cellular response to DNA damage is mediated by evolutionarily conserved Ser/Thr kinases, phosphorylation of Cdc25 protein… (More)
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Highly Cited
2004
Highly Cited
2004
The checkpoint kinases Chk1 and Chk2 are central to the induction of cell cycle arrest, DNA repair, and apoptosis as elements in… (More)
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Highly Cited
2003
Highly Cited
2003
Most human somatic cells can undergo only a limited number of population doublings in vitro. This exhaustion of proliferative… (More)
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Highly Cited
2002
Highly Cited
2002
We have examined the role of checkpoint pathways in responding to a yku70Delta defect in budding yeast. We show that CHK1, MEC1… (More)
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Highly Cited
2001
Highly Cited
2001
Chk1 is an evolutionarily conserved protein kinase that regulates cell cycle progression in response to checkpoint activation. In… (More)
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Highly Cited
2000
Highly Cited
2000
Chk1, an evolutionarily conserved protein kinase, has been implicated in cell cycle checkpoint control in lower eukaryotes. By… (More)
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Highly Cited
1998
Highly Cited
1998
Cdc2, the kinase that induces mitosis, is regulated by checkpoints that couple mitosis to the completion of DNA replication and… (More)
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Highly Cited
1997
Highly Cited
1997
In response to DNA damage, mammalian cells prevent cell cycle progression through the control of critical cell cycle regulators… (More)
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