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CHEK1 protein, human

Known as: Cell Cycle Checkpoint Kinase, CHEK1, Serine/Threonine-Protein Kinase CHK1 
Serine/threonine-protein kinase Chk1 (476 aa, ~54 kDa) is encoded by the human CHEK1 gene. This protein is involved in both DNA damage response and… 
National Institutes of Health

Related topics

Related topics

24 relations
7-hydroxystaurosporineATM Signaling PathwayCDC25 and CHK1 Regulatory PathwayCHEK1 gene

Broader (1)

Checkpoint kinase 1

Papers overview

Semantic Scholar uses AI to extract papers important to this topic.
Review
2011
Review
2011
Safeguarding genome integrity: the checkpoint kinases ATR, CHK1 and WEE1 restrain CDK activity during normal DNA replication
Mechanisms that preserve genome integrity are highly important during the normal life cycle of human cells. Loss of genome… 
Highly Cited
2006
Highly Cited
2006
Rapid Activation of ATR by Ionizing Radiation Requires ATM and Mre11*
The ataxia-telangiectasia-mutated (ATM) and ATM- and Rad3-related (ATR) protein kinases are crucial regulatory proteins in… 
Highly Cited
2006
Highly Cited
2006
Polo-like Kinase-1 Controls Proteasome-Dependent Degradation of Claspin during Checkpoint Recovery
Highly Cited
2005
Highly Cited
2005
Lack of PTEN sequesters CHK1 and initiates genetic instability.
Review
2004
Review
2004
G2 checkpoint abrogators as anticancer drugs.
Many conventional anticancer treatments kill cells irrespective of whether they are normal or cancerous, so patients suffer from… 
Highly Cited
2004
Highly Cited
2004
The DNA crosslink‐induced S‐phase checkpoint depends on ATR–CHK1 and ATR–NBS1–FANCD2 pathways
The genetic syndrome Fanconi anemia (FA) is characterized by aplastic anemia, cancer predisposition and hypersensitivity to DNA… 
Highly Cited
2004
Highly Cited
2004
p73 induction after DNA damage is regulated by checkpoint kinases Chk1 and Chk2.
The checkpoint kinases Chk1 and Chk2 are central to the induction of cell cycle arrest, DNA repair, and apoptosis as elements in… 
Highly Cited
2003
Highly Cited
2003
Chk1‐deficient tumour cells are viable but exhibit multiple checkpoint and survival defects
The conserved protein kinase Chk1 is believed to play an important role in checkpoint responses to aberrant DNA structures… 
Highly Cited
2003
Highly Cited
2003
Ataxia-telangiectasia-mutated (ATM) and NBS1-dependent Phosphorylation of Chk1 on Ser-317 in Response to Ionizing Radiation*
In mammals, the ATM (ataxia-telangiectasia-mutated) and ATR (ATM and Rad3-related) protein kinases function as critical… 
Highly Cited
2002
Highly Cited
2002
S Phase and G2 Arrests Induced by Topoisomerase I Poisons Are Dependent on ATR Kinase Function*
ATR, a human phosphatidylinositol 3-kinase-related kinase, is an important component of the cellular response to DNA damage. In… 
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