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Matrix Crosslinking Forces Tumor Progression by Enhancing Integrin Signaling
Tumors are characterized by extracellular matrix (ECM) remodeling and stiffening. The importance of ECM remodeling to cancer is appreciated; the relevance of stiffening is less clear. We found thatExpand
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Regulation of Hypoxia-Inducible Factor 1α Expression and Function by the Mammalian Target of Rapamycin
ABSTRACT Hypoxia-inducible factor 1 (HIF-1) is a heterodimeric transcription factor containing an inducibly expressed HIF-1α subunit and a constititutively expressed HIF-1β subunit. Under hypoxicExpand
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Hypoxia-induced lysyl oxidase is a critical mediator of bone marrow cell recruitment to form the premetastatic niche.
Tumor cell metastasis is facilitated by "premetastatic niches" formed in destination organs by invading bone marrow-derived cells (BMDCs). Lysyl oxidase (LOX) is critical for premetastatic nicheExpand
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The complexity of p53 modulation: emerging patterns from divergent signals.
Functional inactivation of p53 by gene mutation and deletion, protein degradation, or viral oncogene binding renders a mammalian cell susceptible to oncogenic stimuli and environmental insults thatExpand
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Loss of PTEN facilitates HIF-1-mediated gene expression.
In glioblastoma-derived cell lines, PTEN does not significantly alter apoptotic sensitivity or cause complete inhibition of DNA synthesis. However, in these cell lines PTEN regulates hypoxia- andExpand
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The role of hypoxia-inducible factors in tumorigenesis
Hypoxia-inducible factors (HIFs) are essential mediators of the cellular oxygen-signaling pathway. They are heterodimeric transcription factors consisting of an oxygen-sensitive alpha subunit (HIF-α)Expand
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The unique physiology of solid tumors: opportunities (and problems) for cancer therapy.
The physiology of solid tumors differs from that of normal tissues in a number of important aspects, the majority of which stem from differences between the two vasculatures. Compared with theExpand
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Hypoxia-mediated selection of cells with diminished apoptotic potential in solid tumours
APOPTOSIS is a genetically encoded programme of cell death that can be activated under physiological conditions1,2 and may be an important safeguard against tumour development3–6. Regions of lowExpand
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Hypoxia-inducible mir-210 regulates normoxic gene expression involved in tumor initiation.
Previous studies have suggested that the HIF transcription factors can both activate and inhibit gene expression. Here we show that HIF1 regulates the expression of mir-210 in a variety of tumorExpand
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Radiation oncology: a century of achievements
Over the twentieth century the discipline of radiation oncology has developed from an experimental application of X-rays to a highly sophisticated treatment of cancer. Experts from many disciplines —Expand
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