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CHEK1 gene

Known as: CHK1 Checkpoint Homolog (S.Pombe) Gene, CHEK1, CHK1 
This gene is involved in the negative regulation of cell growth.
National Institutes of Health

Related topics

Related topics

6 relations
CHEK1 protein, humanCheckpoint kinase 1Negative Regulation of Cell CyclePhosphorylation

Papers overview

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2020
2020
Integrated analysis of key microRNAs /TFs /mRNAs/ in HPV-positive cervical cancer based on microRNA sequencing and bioinformatics analysis.
2020
2020
Next-generation sequencing in thymic epithelial tumors uncovered novel genomic aberration sites and strong correlation between TMB and MSH6 single nucleotide variations.
2018
2018
CHEK1 coordinates DNA damage signaling and meiotic progression in the male germline of mice
The continuity of life depends on mechanisms in the germline that ensure the integrity of the genome. The DNA damage response… 
2017
2017
Molecular characterization and multi-locus genotypes of Enterocytozoon bieneusi from captive red kangaroos (Macropus Rfus) in Jiangsu province, China
Enterocytozoon bieneusi is the most common pathogen of microsporidian species infecting humans worldwide. Although E. bieneusi… 
2017
2017
Associations between mutations of the cell cycle checkpoint kinase 2 gene and gastric carcinogenesis.
Gastric cancer is the most common malignant tumor of the digestive system. The etiology of gastric cancer is complex, and… 
2016
2016
Relationships between cell cycle pathway gene polymorphisms and risk of hepatocellular carcinoma.
AIM To investigate the associiations between the polymorphisms of cell cycle pathway genes and the risk of hepatocellular… 
2016
2016
Screening of Pleural Mesotheliomas for DNA-damage Repair Players by Digital Gene Expression Analysis Can Enhance Clinical Management of Patients Receiving Platin-Based Chemotherapy
Background: Malignant pleural mesothelioma (MPM) is a rare, predominantly asbestos-related and biologically highly aggressive… 
2014
2014
Loss of compensatory pro-survival and anti-apoptotic modulator, IKKε, sensitizes ovarian cancer cells to CHEK1 loss through an increased level of p21
Ovarian cancer (OC) is extremely heterogeneous, implying that therapeutic strategies should be specifically designed based on… 
2013
2013
Associations of ATR and CHEK1 Single Nucleotide Polymorphisms with Breast Cancer
DNA damage and replication checkpoints mediated by the ATR-CHEK1 pathway are key to the maintenance of genome stability, and both… 
2008
2008
Global analysis of gene expression changes during retinoic acid-induced growth arrest and differentiation of melanoma: comparison to differentially expressed genes in melanocytes vs melanoma
BackgroundThe incidence of malignant melanoma has significantly increased over the last decade. Some of these malignancies are… 
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