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Multiancestry genome-wide association study of 520,000 subjects identifies 32 loci associated with stroke and stroke subtypes
A multiancestry genome-wide-association meta-analysis and discovered 22 new stroke risk loci, indicating mechanisms not previously implicated in stroke pathophysiology, with prioritization of risk variants and genes accomplished through bioinformatics analyses using extensive functional datasets. Expand
Genetic analysis of over 1 million people identifies 535 new loci associated with blood pressure traits
The largest genetic association study of blood pressure traits (systolic, diastolic and pulse pressure) to date in over 1 million people of European ancestry identifies 535 novel blood pressure loci that offer new insights into blood pressure regulation. Expand
Fifteen new risk loci for coronary artery disease highlight arterial-wall-specific mechanisms
25 new SNP–CAD associations are identified from 15 genomic regions, including SNPs in or near genes involved in cellular adhesion, leukocyte migration and atherosclerosis, coagulation and inflammation and vascular smooth muscle cell differentiation, which sheds light on potential disease mechanisms. Expand
Comparison between extracorporeal shock wave lithotripsy and semirigid ureterorenoscope with holmium:YAG laser lithotripsy for treating large proximal ureteral stones.
- Ching-Fang Wu, J. Shee, Wei-Yu Lin, Chun-Liang Lin, Chih-Shou Chen
- The Journal of urology
- 1 November 2004
This study demonstrated that URSL achieved excellent results for upper ureteral calculi greater than 1 cm and should be considered first line therapy for large proximal ureTERal stones. Expand
The methylenetetrahydrofolate reductase 677C-->T polymorphism and lung cancer risk in a Chinese population.
Results suggest that the MTHFR 677T variant genotype reduces the risk of lung cancer, and larger studies incorporating dietary folate intake and the variant genotypes are needed to clarify the results. Expand
Therapeutic options for proximal ureter stone: extracorporeal shock wave lithotripsy versus semirigid ureterorenoscope with holmium:yttrium-aluminum-garnet laser lithotripsy.
The results of this study have demonstrated that URSL achieved excellent results for upper ureter calculi and should be the first-line therapy for proximal Ureteral stones in terms of cost and effectiveness. Expand
Meta Association of Colorectal Cancer Confirms Risk Alleles at 8q24 and 18q21
- K. Curtin, Wei-Yu Lin, +6 authors N. Camp
- Cancer Epidemiology Biomarkers & Prevention
- 1 February 2009
This investigation confirms that variants across multiple risk regions of 8q24 are associated with CRC, and that associations at 18q21 differ by tumor site, as confirmed in a three-center collaborative study. Expand
Genetic Variants in XRCC2: New Insights Into Colorectal Cancer Tumorigenesis
- K. Curtin, Wei-Yu Lin, +7 authors N. Camp
- Cancer Epidemiology, Biomarkers & Prevention
- 1 September 2009
A role for XRCC2 in colorectal cancer tumorigenesis, conferring susceptibility to rectal tumors is supported, and a novel, highly significant association of a common SNP, rs3218499G>C, with increased risk of rectal cancers is observed. Expand
Polymorphic catechol-O-methyltransferase gene, duration of estrogen exposure, and breast cancer risk: a nested case-control study in Taiwan.
It is suggested that there may be no overall association of COMT genotype with breast cancer, but the COMT-L allele could pose enhanced risk of breast cancer in the presence of relevant environmental exposures, as most low penetrance gene are expected to act through gene-environment interactions. Expand
Whole-Genome Sequencing Coupled to Imputation Discovers Genetic Signals for Anthropometric Traits
- I. Tachmazidou, D. Süveges, +100 authors E. Zeggini
- Biology, Medicine
- American journal of human genetics
- 25 May 2017
This work applied a hybrid whole-genome sequencing (WGS) and deep imputation approach to examine the broader allelic architecture of 12 anthropometric traits associated with height, body mass, and fat distribution in up to 267,616 individuals to report 106 genome-wide significant signals that have not been previously identified. Expand