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Negative Regulation of Cell Cycle

Known as: negative regulation of progression through cell cycle, downregulation of progression through cell cycle, Cell Cycle Inhibition 
An interruption in the periodic biochemical and structural events occurring during proliferation of cells such as in tissue culture; the cycle is… 
National Institutes of Health

Related topics

Related topics

50 relations
ARRY 520AZD 4877CDK inhibitor AT7519MCDK2/5/9 Inhibitor CYC065

Broader (1)

biological control

Papers overview

Semantic Scholar uses AI to extract papers important to this topic.
Review
2008
Review
2008
PTEN: a new guardian of the genome
The phosphatase and tensin homolog deleted on chromosome 10 (PTEN) tumor suppressor is a phosphatase that antagonizes the… 
Highly Cited
2006
Highly Cited
2006
Antibody-maytansinoid conjugates are activated in targeted cancer cells by lysosomal degradation and linker-dependent intracellular processing.
Antibody-drug conjugates are targeted anticancer agents consisting of a cytotoxic drug covalently linked to a monoclonal antibody… 
Highly Cited
2006
Highly Cited
2006
Berberine, a natural product, induces G1-phase cell cycle arrest and caspase-3-dependent apoptosis in human prostate carcinoma cells
Berberine, a naturally occurring isoquinoline alkaloid, has been shown to possess anti-inflammatory and antitumor properties in… 
Highly Cited
2005
Highly Cited
2005
Cell cycle inhibition provides neuroprotection and reduces glial proliferation and scar formation after traumatic brain injury.
Traumatic brain injury (TBI) causes neuronal apoptosis, inflammation, and reactive astrogliosis, which contribute to secondary… 
Highly Cited
2004
Highly Cited
2004
Methylation of Histone H4 Lysine 20 Controls Recruitment of Crb2 to Sites of DNA Damage
Highly Cited
2004
Highly Cited
2004
Sulforaphane-induced G2/M Phase Cell Cycle Arrest Involves Checkpoint Kinase 2-mediated Phosphorylation of Cell Division Cycle 25C*
Previously, we showed that sulforaphane (SFN), a naturally occurring cancer chemopreventive agent, effectively inhibits… 
Highly Cited
2003
Highly Cited
2003
Disruption of the nucleolus mediates stabilization of p53 in response to DNA damage and other stresses
p53 protects against cancer through its capacity to induce cell cycle arrest or apoptosis under a large variety of cellular… 
Highly Cited
1998
Highly Cited
1998
p21 binding to PCNA causes G1 and G2 cell cycle arrest in p53-deficient cells
A unique feature of p21 that distinguishes it from the other cyclin-dependent kinase (CDK) inhibitors is its ability to associate… 
Highly Cited
1997
Highly Cited
1997
The polyproline region of p53 is required to activate apoptosis but not growth arrest
p53 is a pivotal regulator of apoptosis but its mechanism of action is obscure. We report that the polyproline (PP) region… 
Highly Cited
1994
Highly Cited
1994
Myc-mediated apoptosis requires wild-type p53 in a manner independent of cell cycle arrest and the ability of p53 to induce p21waf1/cip1.
Deregulated expression of the c-myc proto-oncogene can lead to apoptosis under certain physiological conditions. By introducing a… 
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