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Tumor Cells Circulate in the Peripheral Blood of All Major Carcinomas but not in Healthy Subjects or Patients With Nonmalignant Diseases
Purpose: The purpose of this study was to determine the accuracy, precision, and linearity of the CellSearch system and evaluate the number of circulating tumor cells (CTCs) per 7.5 mL of blood inExpand
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Circulating Tumor Cells in Patients with Breast Cancer Dormancy
Purpose: The purpose of this study was to test the hypothesis that circulating tumor cells (CTCs) are present in patients many years after mastectomy without evidence of disease and that these CTCsExpand
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Detection and characterization of carcinoma cells in the blood.
  • E. Racila, D. Euhus, +4 authors J. Uhr
  • Biology, Medicine
  • Proceedings of the National Academy of Sciences…
  • 14 April 1998
A highly sensitive assay combining immunomagnetic enrichment with multiparameter flow cytometric and immunocytochemical analysis has been developed to detect, enumerate, and characterize carcinomaExpand
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HER-2 gene amplification can be acquired as breast cancer progresses.
Amplification and overexpression of the HER-2 oncogene in breast cancer is felt to be stable over the course of disease and concordant between primary tumor and metastases. Therefore, patients withExpand
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Regulatory effect of antibody on the immune response.
Publisher Summary This chapter deals with the regulatory effect of antibody on antibody formation. It is possible to analyze those factors that influence the process of antibody synthesis. CertainlyExpand
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Increased expression of Ia antigens on resting B cells: an additional role for B-cell growth factor.
The present studies demonstrate that both T-cell-derived supernatants containing B-cell growth factor (BCGF or BSF) and a partially purified preparation of the B-cell growth factor (BSF-p1) induce anExpand
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Synthesis of germ-line gamma 1 immunoglobulin heavy-chain transcripts in resting B cells: induction by interleukin 4 and inhibition by interferon gamma.
Interleukin 4 (IL-4) induces the expression of IgG1 and IgE in lipopolysaccharide-stimulated B cells. Previous studies have suggested that heavy-chain class switching may be regulated by increasingExpand
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uPAR and HER-2 gene status in individual breast cancer cells from blood and tissues
  • S. Meng, D. Tripathy, +17 authors J. Uhr
  • Biology, Medicine
  • Proceedings of the National Academy of Sciences
  • 14 November 2006
Overexpression of urokinase plasminogen activator system or HER-2 (erbB-2) in breast cancer is associated with a poor prognosis. HER-2 overexpression is caused by HER-2 gene amplification. TheExpand
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Challenges in the Enumeration and Phenotyping of CTC
Purpose: Presence of circulating tumor cells (CTC) in metastatic carcinoma is associated with poor survival. Phenotyping and genotyping of CTC may permit “real-time” treatment decisions, providedExpand
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Antibody formation. I. The suppression of antibody formation by passively administered antibody.
The suppression of antibody formation by passively administered antibody is influenced by the dose and nature of the antigen, type of immunization procedure, ratio of antibody to antigen, speciesExpand
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