Two arginine rich domains in the p14ARF tumour suppressor mediate nucleolar localization

@article{Rizos2000TwoAR,
  title={Two arginine rich domains in the p14ARF tumour suppressor mediate nucleolar localization},
  author={Helen Rizos and Artur P Darmanian and Graham J. Mann and Richard F. Kefford},
  journal={Oncogene},
  year={2000},
  volume={19},
  pages={2978-2985}
}
The INK4a/ARF locus encodes two distinct tumour suppressors, p16INK4a and p14ARF, that regulate cell cycle progression via the pRB and p53 pathways, respectively. The ARF protein inhibits hdm2 activity, leading to the stabilization of the p53 tumour suppressor and cell cycle inhibition. The amino-terminal domain of human p14ARF and of the mouse homologue, p19ARF, is sufficient for these effects. This domain is also sufficient for the nucleolar localization of the mouse ARF protein. In contrast… CONTINUE READING
BETA

From This Paper

Figures, tables, and topics from this paper.

Citations

Publications citing this paper.
SHOWING 1-10 OF 33 CITATIONS

References

Publications referenced by this paper.
SHOWING 1-10 OF 18 REFERENCES

Molec

  • Y Zhang, Y. Xiong
  • Cell, 3, 579 ± 591.
  • 1999
Highly Influential
15 Excerpts

Familial Melanoma Study Group, Be nard

  • N Sou®r, M-F Avril, +5 authors Group
  • J and Bressac-de Paillerets B
  • 1998
Highly Influential
4 Excerpts

Int

  • S Piccinin, C Doglioni, +4 authors M. Boiocchi
  • J. Cancer, 74, 26 ± 30.
  • 1997
Highly Influential
4 Excerpts

Proc

  • DE Quelle, M Cheng, RA Ashmum, CJ. Sherr
  • Natl. Acad. Sci. USA, 94, 669 ± 673.
  • 1997
Highly Influential
12 Excerpts

J

  • A Platz, J Hansson, +6 authors U. Ringborg
  • Nat. Cancer Inst., 89, 697 ± 702.
  • 1997
Highly Influential
6 Excerpts

Curr

  • NE Sharpless, DePinho RA.
  • Opin. Genet. Dev., 9, 22 ± 30.
  • 1999

Exp

  • S Lain, C Midgley, A Sparks, EB Lane, DP. Lane
  • Cell. Res., 248, 457 ± 472.
  • 1999
2 Excerpts

Proc

  • W Tao, Levine AJ.
  • Natl. Acad. Sci. USA, 96, 3077 ± 3080.
  • 1999

Mol

  • I-JL Byeon, J Li, +5 authors M-D. Tsai
  • Cell., 1, 421 ± 431.
  • 1998
3 Excerpts

Proc

  • T Kamijo, JD Weber, G Zambetti, F Zindy, MF Roussel, CJ. Sherr
  • Natl. Acad. Sci. USA, 95, 8292 ± 8297.
  • 1998

Similar Papers

Loading similar papers…