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ARRY 520

Known as: ARRY-520, KSP Inhibitor ARRY-520 
A synthetic, small molecule targeting the kinesin spindle protein (KSP) with potential antineoplastic activity. KSP inhibitor ARRY-520 specifically… Expand
National Institutes of Health

Papers overview

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2015
2015
SummaryPurpose Filanesib (ARRY-520) is a highly selective, targeted inhibitor of kinesin spindle protein (KSP) inhibitor that… Expand
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Review
2014
Review
2014
The development of bortezomib and immunomodulatory agents resulted in a revolution in the treatment of multiple myeloma (MM… Expand
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2013
2013
Background The availability of multiple immunomodulators (IMiDs) and proteasome inhibitors (PIs) has resulted in improved… Expand
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Review
2013
Review
2013
There have been major advances in the past decade in the continuum of therapy for transplantation-eligible multiple myeloma… Expand
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2011
2011
Abstract 1860 Background: ARRY-520 is a potent, selective inhibitor of kinesin spindle protein (KSP, eg5) which is required for… Expand
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2010
2010
Kinesin spindle protein (KSP/Eg5) inhibitors are novel anticancer agents that have thus far shown only modest activity in the… Expand
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2009
2009
Kinesin spindle protein (KSP), a microtubule-associated motor protein essential for cell cycle progression, is overexpressed in… Expand
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2009
2009
AIM Profiling the efficacy and pharmacodynamic activity of the kinesin spindle protein (KSP) inhibitor ARRY-520 will aid the… Expand
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2009
2009
BackgroundWe previously described a sub-population of epithelial ovarian cancer (EOC) cells with a functional TLR-4/MyD88/NF-κB… Expand
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2009
2009
David J Cennimo, MD, FAAP, AAHIVS, Fellow in Infectious Diseases, Department of Pediatrics, University of Medicine and Dentistry… Expand
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