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Checkpoint kinase 1

Known as: Chk1 Kinase, Checkpoint Kinase 1 [Chemical/Ingredient], Chk1 Protein Kinase 
A serine/threonine-specific protein kinase which is encoded by the CHEK1 gene in humans. Checkpoint kinase 1 (also known as Chk1) coordinates DNA… 
National Institutes of Health

Related topics

Related topics

12 relations
CHEK1 geneIn BloodProcess of secretionantagonists & inhibitors

Narrower (4)

CHEK1 protein, humanChek1 protein, mouseChek1 protein, ratChk1 protein, Xenopus

Papers overview

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Highly Cited
2011
Highly Cited
2011
Assessment of Chk1 Phosphorylation as a Pharmacodynamic Biomarker of Chk1 Inhibition
Purpose: Chk1 inhibitors, such as AZD7762, are in clinical development in combination with cytotoxic agents for the treatment of… 
Highly Cited
2010
Highly Cited
2010
Histone Deacetylase Inhibitors Downregulate Checkpoint Kinase 1 Expression to Induce Cell Death in Non-Small Cell Lung Cancer Cells
Background Histone deacetylase inhibitors (HDACis) are promising anticancer drugs; however, the molecular mechanisms leading to… 
Highly Cited
2009
Highly Cited
2009
Gemcitabine sensitization by checkpoint kinase 1 inhibition correlates with inhibition of a Rad51 DNA damage response in pancreatic cancer cells
The protein kinase checkpoint kinase 1 (Chk1) has been implicated as a key regulator of cell cycle progression and DNA repair… 
Highly Cited
2006
Highly Cited
2006
Adaptation to the ionizing radiation-induced G2 checkpoint occurs in human cells and depends on checkpoint kinase 1 and Polo-like kinase 1 kinases.
Checkpoint adaptation was originally defined in yeast as the ability to divide despite the presence of damaged DNA. An important… 
Highly Cited
2006
Highly Cited
2006
Checkpoint kinase 1 (Chk1) is required for mitotic progression through negative regulation of polo-like kinase 1 (Plk1)
Although the essential function of checkpoint kinase 1 (Chk1) in DNA damage response has been well established, the role of Chk1… 
Highly Cited
2006
Highly Cited
2006
Chaperoning Checkpoint Kinase 1 (Chk1), an Hsp90 Client, with Purified Chaperones*
Checkpoint kinase 1 (Chk1), a serine/threonine kinase that regulates DNA damage checkpoints, is destabilized when heat shock… 
Highly Cited
2006
Highly Cited
2006
Differential roles of checkpoint kinase 1, checkpoint kinase 2, and mitogen-activated protein kinase–activated protein kinase 2 in mediating DNA damage–induced cell cycle arrest: implications for…
Mammalian cells initiate cell cycle arrest at different phases of the cell cycle in response to various forms of genotoxic stress… 
Highly Cited
2005
Highly Cited
2005
Checkpoint Kinase 1 Regulates Diallyl Trisulfide-induced Mitotic Arrest in Human Prostate Cancer Cells*
We have shown previously that diallyl trisulfide (DATS), a constituent of processed garlic, inhibits proliferation of PC-3 and… 
Review
2000
Review
2000
Small molecule modulators of cyclin-dependent kinases for cancer therapy
The majority of human malignancies have aberrancies in the Retinoblastoma (Rb) pathway. Loss in Rb function results from the… 
Highly Cited
1998
Highly Cited
1998
Analysis of Rad3 and Chk1 protein kinases defines different checkpoint responses
Eukaryotic cells respond to DNA damage and S phase replication blocks by arresting cell‐cycle progression through the DNA… 
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