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Checkpoint kinase 1

Known as: Chk1 Kinase, Checkpoint Kinase 1 [Chemical/Ingredient], Chk1 Protein Kinase 
A serine/threonine-specific protein kinase which is encoded by the CHEK1 gene in humans. Checkpoint kinase 1 (also known as Chk1) coordinates DNA… 
National Institutes of Health

Related topics

Related topics

12 relations
CHEK1 geneIn BloodProcess of secretionantagonists & inhibitors

Narrower (4)

CHEK1 protein, humanChek1 protein, mouseChek1 protein, ratChk1 protein, Xenopus

Papers overview

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2019
2019
The ribonucleoside AICAr induces differentiation of myeloid leukemia by activating the ATR/Chk1 via pyrimidine depletion
Metabolic pathways play important roles in proliferation and differentiation of malignant cells. 5-Aminoimidazole-4-carboxamide… 
2014
2014
Checkpoint kinase 1 negatively regulates somatic hypermutation
Immunoglobulin (Ig) diversification by somatic hypermutation in germinal center B cells is instrumental for maturation of the… 
2013
2013
Cheliensisin A Inhibits EGF-Induced Cell Transformation with Stabilization of p53 Protein Via a Hydrogen Peroxide/Chk1-Dependent Axis
Cheliensisin A (Chel A), a novel styryl-lactone isolated from Goniothalamus cheliensis Hu, has been shown to induce apoptosis in… 
2011
2011
Toxic effects of methylated benzo[a]pyrenes in rat liver stem-like cells.
The methylated benzo[a]pyrenes (MeBaPs) are present at significant levels in the environment, especially in the sediments… 
2008
2008
Checkpoints meet the transcription at a novel histone milestone (H3-T11)
Eukaryotic cells are equipped with coordinated systems to contend with DNA damage, such as those which are used in cell cycle… 
2008
2008
Apoptosis induced by replication inhibitors in Chk1-depleted cells is dependent upon the helicase cofactor Cdc45
Checkpoint kinase 1 (Chk1) responds to disruption of DNA replication to maintain the integrity of stalled forks, promote… 
2006
2006
Phosphorylation of Chk 1 by ATR Is Antagonized by a Chk 1-Regulated Protein Phosphatase 2 A Circuit †
2006
2006
Dissecting the Roles of Checkpoint Kinase 1/CDC2 and Mitogen-Activated Protein Kinase Kinase 1/2/Extracellular Signal-Regulated Kinase 1/2 in Relation to 7-Hydroxystaurosporine-Induced Apoptosis in…
The functional roles of Cdc2 and checkpoint kinase 1 (Chk1) in synergistic interactions between 7-hydroxystaurosporine (UCN-01… 
2006
2006
Antagonism of Chk1 Signaling in the G2 DNA Damage Checkpoint by Dominant Alleles of Cdr1
Activation of the Chk1 protein kinase by DNA damage enforces a checkpoint that maintains Cdc2 in its inactive, tyrosine-15 (Y15… 
2000
2000
Mechanism of ultraviolet B-induced cell cycle arrest in G2/M phase in immortalized skin keratinocytes with defective p53.
The ultraviolet B (UVB) portion (280-320 nm) of solar radiation is considered to be a major etiologic factor in human skin cancer… 
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