Checkpoint kinase 1

Known as: Chk1 Kinase, Checkpoint Kinase 1 [Chemical/Ingredient], Chk1 Protein Kinase 
A serine/threonine-specific protein kinase which is encoded by the CHEK1 gene in humans. Checkpoint kinase 1 (also known as Chk1) coordinates DNA… (More)
National Institutes of Health

Papers overview

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Review
2013
Review
2013
Originally identified as a mediator of DNA damage response (DDR), checkpoint kinase 1 (Chk1) has a broader role in checkpoint… (More)
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Highly Cited
2011
Highly Cited
2011
Neuroblastoma is a childhood cancer that is often fatal despite intense multimodality therapy. In an effort to identify… (More)
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Review
2010
Review
2010
The DNA damage response (DDR) represents a complex network of multiple signaling pathways involving cell cycle checkpoints, DNA… (More)
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2009
2009
Defective genome maintenance mechanisms, involving DNA repair and cell-cycle checkpoint pathways, initiate genetic instability in… (More)
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Highly Cited
2009
Highly Cited
2009
The protein kinase checkpoint kinase 1 (Chk1) has been implicated as a key regulator of cell cycle progression and DNA repair… (More)
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Highly Cited
2006
Highly Cited
2006
Checkpoint adaptation was originally defined in yeast as the ability to divide despite the presence of damaged DNA. An important… (More)
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Highly Cited
2006
Highly Cited
2006
Although the essential function of checkpoint kinase 1 (Chk1) in DNA damage response has been well established, the role of Chk1… (More)
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2006
2006
Checkpoint kinase 1 (Chk1), a serine/threonine kinase that regulates DNA damage checkpoints, is destabilized when heat shock… (More)
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Highly Cited
2005
Highly Cited
2005
We have shown previously that diallyl trisulfide (DATS), a constituent of processed garlic, inhibits proliferation of PC-3 and… (More)
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Highly Cited
2002
Highly Cited
2002
The breast cancer tumor-suppressor gene, BRCA1, encodes a protein with a BRCT domain—a motif that is found in many proteins that… (More)
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