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Oxidative stress in the pathogenesis of skin disease.
One approach to preventing or treating these ROS-mediated disorders is based on the administration of various antioxidants in an effort to restore homeostasis.
Induction of oxyradicals by arsenic: implication for mechanism of genotoxicity.
- S. X. Liu, M. Athar, I. Lippai, C. Waldren, T. Hei
- Biology, ChemistryProceedings of the National Academy of Sciences…
- 13 February 2001
Confocal scanning microscopy shows that arsenite induces, within 5 min after treatment, a dose-dependent increase of up to 3-fold in intracellular oxyradical production, providing convincing evidence that reactive oxygen species, particularly hydroxyl radicals, play an important causal role in the genotoxicity of arsenical compounds in mammalian cells.
Resveratrol: a review of preclinical studies for human cancer prevention.
Cyclooxygenase-2 Expression in Murine and Human Nonmelanoma Skin Cancers: Implications for Therapeutic Approaches¶
Enhanced COX-2 expression serves as a marker of epidermal UVB exposure for murine and human NMSC and is suggested to have potent anticarcinogenic effects in UVB-induced skin cancer.
Punica granatum (pomegranate) flower extract possesses potent antioxidant activity and abrogates Fe-NTA induced hepatotoxicity in mice.
Hedgehog signalling in skin development and cancer
- M. Athar, Xiuwei Tang, Juliette L. Lee, L. Kopelovich, A. Kim
- Biology, MedicineExperimental dermatology
- 1 September 2006
A current understanding of the role of the Shh pathway in skin development and neoplasia is provided, which provides a basis for the molecular target‐based chemoprevention and therapeutic management of skin cancer.
Porphyrin-mediated photosensitization has a weak tumor promoting activity in mouse skin: possible role of in situ-generated reactive oxygen species.
It is shown that in situ-generated ROS act as weak complete tumor promoters in 7,12-dimethylbenz[a]anthracene (DMBA)-initiated mouse skin and porphyrin-mediated photosensitization has a weak tumor promoting effect in mouse skin.
Evaluation of antioxidant activity of Cassia siamea flowers.
Multiple molecular targets of resveratrol: Anti-carcinogenic mechanisms.