• Publications
  • Influence
Oxidative stress in the pathogenesis of skin disease.
  • D. Bickers, M. Athar
  • Biology, Medicine
  • The Journal of investigative dermatology
  • 1 December 2006
One approach to preventing or treating these ROS-mediated disorders is based on the administration of various antioxidants in an effort to restore homeostasis. Expand
The burden of skin diseases: 2004 a joint project of the American Academy of Dermatology Association and the Society for Investigative Dermatology.
Based on a methodology of willingness to pay for symptom relief, the additional economic burden of skin disease on quality of life amounted to an estimated 56.2 billion dollars. Expand
Inhibiting the hedgehog pathway in patients with the basal-cell nevus syndrome.
Vismodegib reduces the basal-cell carcinoma tumor burden and blocks growth of new basal- cell carcinomas in patients with the basal -cell nevus syndrome and the adverse events associated with treatment led to discontinuation in over half of treated patients. Expand
Resveratrol: a review of preclinical studies for human cancer prevention.
The current preclinical and mechanistic data available and resveratrol's anticancer effects are assessed to support its potential as an anticancer agent in human populations are discussed. Expand
Cyclooxygenase-2 Expression in Murine and Human Nonmelanoma Skin Cancers: Implications for Therapeutic Approaches¶
Enhanced COX-2 expression serves as a marker of epidermal UVB exposure for murine and human NMSC and is suggested to have potent anticarcinogenic effects in UVB-induced skin cancer. Expand
A randomized vehicle-controlled trial of topical capsaicin in the treatment of postherpetic neuralgia.
It is concluded that capsaicin 0.075% cream is a safe and effective treatment for the pain of postherpetic neuralgia and should be considered for initial management of patients with this condition. Expand
Dioxin‐induced chloracne – reconstructing the cellular and molecular mechanisms of a classic environmental disease
It is proposed that the dioxin‐induced activation of skin stem cells and a shift in differentiation commitment of their progeny may represent a major mechanism of chloracne development. Expand
A toxicological and dermatological assessment of aryl alkyl alcohols when used as fragrance ingredients.
It is concluded that these materials would not present a safety concern at current levels of use as fragrance ingredients and the potential for photosensitization is low. Expand
Multiple molecular targets of resveratrol: Anti-carcinogenic mechanisms.
There is increasing evidence that resveratrol exhibits pro-oxidant activity under certain experimental conditions, causing oxidative DNA damage that may lead to cell cycle arrest or apoptosis. Expand
Topical capsaicin treatment of chronic postherpetic neuralgia.
It is suggested that topical capsaicin be considered for initial management of postherpetic neuralgia and avoids problems with drug interactions and systemic toxicity. Expand