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Guidelines for the use and interpretation of assays for monitoring autophagy (3rd edition)
TLDR
There continues to be confusion regarding acceptable methods to measure autophagy, especially in multicellular eukaryotes, so it is important to update guidelines for monitoring autophagic activity in different organisms.
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Targeting multiple signaling pathways by green tea polyphenol (-)-epigallocatechin-3-gallate.
TLDR
The modulations of important signaling events by EGCG are discussed and their implications in cancer management are discussed.
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Tea polyphenols for health promotion.
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Tea polyphenols: prevention of cancer and optimizing health.
TLDR
This study will examine the safety and possible efficacy of consuming the equivalent of > or =10 cups (> or =2.4 L) of green tea per day to evaluate the usefulness of tea polyphenols for humans.
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Green tea constituent epigallocatechin-3-gallate and induction of apoptosis and cell cycle arrest in human carcinoma cells.
TLDR
Green tea may protect against cancer by causing cell cycle arrest and inducing apoptosis, and needs to be evaluated in human trials.
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Green tea polyphenol epigallocatechin-3-gallate differentially modulates nuclear factor kappaB in cancer cells versus normal cells.
TLDR
EGCG was found to impart differential dose-based NF-kappaB inhibitory response in cancer cells vs normal cells, and suggests that EGCG-caused cell cycle deregulation and apoptosis of cancer cells may be mediated through NF- kappaB inhibition.
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Inhibition of prostate carcinogenesis in TRAMP mice by oral infusion of green tea polyphenols
TLDR
It is shown that oral infusion of a polyphenolic fraction isolated from green tea (GTP) at a human achievable dose (equivalent to six cups of green tea per day) significantly inhibits CaP development and increases survival in male TRAMP mice.
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Prevention of collagen-induced arthritis in mice by a polyphenolic fraction from green tea.
TLDR
These studies suggest that a polyphenolic fraction from green tea that is rich in antioxidants may be useful in the prevention of onset and severity of arthritis.
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Inhibition of UVB-induced oxidative stress-mediated phosphorylation of mitogen-activated protein kinase signaling pathways in cultured human epidermal keratinocytes by green tea polyphenol…
TLDR
It is demonstrated that pretreatment of NHEK with (-)-epigallocatechin-3-gallate (EGCG), an antioxidant from green tea, inhibits UVB-induced hydrogen peroxide production and H(2)O(2)-mediated phosphorylation of MAPK signaling pathways, suggesting that EGCG could be useful in attenuation of oxidative stress-mediated and MAPK-caused skin disorders in humans.
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Cannabinoid receptor as a novel target for the treatment of prostate cancer.
TLDR
The results suggest that WIN-55,212-2 or other non-habit-forming cannabinoid receptor agonists could be developed as novel therapeutic agents for the treatment of prostate cancer.
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