• Publications
  • Influence
Biochemical and cellular effects of roscovitine, a potent and selective inhibitor of the cyclin-dependent kinases cdc2, cdk2 and cdk5.
TLDR
Through its unique selectivity for some cyclin-dependent kinases, roscovitine provides a useful antimitotic reagent for cell cycle studies and may prove interesting to control cells with deregulated cdc2, cdk2 or cdk5 kinase activities. Expand
Isoquinolinesulfonamides, novel and potent inhibitors of cyclic nucleotide dependent protein kinase and protein kinase C.
TLDR
Both the holoenzyme and the catalytic subunit (or fragment), which is active without an enzyme activator, are susceptible to these compounds with a similar concentration dependency, thereby indicating that the inhibitory effect is attributed to the direct interaction of the compound with the active center of the enzyme but not with the enzymeactivator. Expand
Phosphorylation of Myosin-Binding Subunit (Mbs) of Myosin Phosphatase by Rho-Kinase in Vivo
TLDR
Results indicate that MBS is phosphorylated by Rho-kinase downstream of Rho in vivo, and suggest that myosin phosphatase and Rho -kinase spatiotemporally regulate the phosphorylation state of RHo-kinases substrates including MLC and ERM family proteins in vivo in a cooperative manner. Expand
Direct interaction of Plk4 with STIL ensures formation of a single procentriole per parental centriole
TLDR
It is shown that Plk4 and STIL, the key regulators of centriole formation, form a protein complex that provides a scaffold for recruiting HsSAS-6, a major component of the centriolar cartwheel, at the onset of procentrioles formation. Expand
Identification of a Novel Phosphorylation Site on Histone H3 Coupled with Mitotic Chromosome Condensation*
TLDR
Observations suggest that H3 phosphorylation at Ser28, together with Ser10, is a conserved event and is likely to be involved in mitotic chromosome condensation. Expand
Filament Formation of MSF-A, a Mammalian Septin, in Human Mammary Epithelial Cells Depends on Interactions with Microtubules*
TLDR
Findings of immunocytochemical and biochemical characterization of a mammalian septin, MSF-A, strongly suggest that septin filaments may interact not only with actin filaments but also with microtubule networks and that GTPase activity is not indispensable to incorporation of MSf-A into septin Filaments. Expand
Vimentin organization modulates the formation of lamellipodia
TLDR
The disassembly and withdrawal of vimentin intermediate filaments from the plasma membrane induces membrane ruffling and the formation of a lamellipodium and this formation is inhibited when VIF are present. Expand
Barrier-to-autointegration factor plays crucial roles in cell cycle progression and nuclear organization in Drosophila
TLDR
It is concluded that BAF plays essential roles in nuclear organization and that these BAF functions are required in both M phase and interphase of the cell cycle. Expand
Aurora‐B phosphorylates Histone H3 at serine28 with regard to the mitotic chromosome condensation
TLDR
It is reported that H3 phosphorylation occurs at Ser28, as well as at Ser10 during mitosis, at least in mammals, and Aurora B was recently demonstrated to be responsible for Ser10 phosphorylated in S. cerevisiae, Drosophila and Xenopus egg extract. Expand
Phosphorylation by aurora B converts MgcRacGAP to a RhoGAP during cytokinesis.
TLDR
During cytokinesis, MgcRacGAP, previously known as a GAP for Rac/Cdc42, is functionally converted to a RhoGAP through phosphorylation by Aurora B, which induces latent GAP activity toward RhoA in vitro. Expand
...
1
2
3
4
5
...