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ATM Signaling Pathway
The ataxia telangiectasia-mutated gene (ATM) encodes a protein kinase that acts as a tumor suppressor. ATM activation by ionizing radiation damage to…
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National Institutes of Health
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34 relations
ABL1 wt Allele
ATM protein, human
ATM wt Allele
ATRIP protein, human
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Papers overview
Semantic Scholar uses AI to extract papers important to this topic.
2016
2016
Sodium glycididazole enhances the radiosensitivity of laryngeal cancer cells through downregulation of ATM signaling pathway
Yuecan Zeng
,
R. Xing
,
+9 authors
R. Wu
Tumor Biology
2016
Corpus ID: 31145531
The purpose of this study was to evaluate the radiation-enhancing effect of sodium glycididazole, and the corresponding…
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2012
2012
Competition between NBS1 and ATMIN controls ATM signaling pathway choice.
Tianyi Zhang
,
K. Penicud
,
+4 authors
A. Behrens
Cell Reports
2012
Corpus ID: 5160738
2011
2011
Autophagy inhibition enhances apoptosis triggered by BO-1051, an N-mustard derivative, and involves the ATM signaling pathway.
Li-Hsin Chen
,
C. Loong
,
+8 authors
S. Chiou
Biochemical Pharmacology
2011
Corpus ID: 25388241
Highly Cited
2009
Highly Cited
2009
Stabilization of quadruplex DNA perturbs telomere replication leading to the activation of an ATR-dependent ATM signaling pathway
A. Rizzo
,
E. Salvati
,
+7 authors
A. Biroccio
Nucleic Acids Research
2009
Corpus ID: 16386925
Functional telomeres are required to maintain the replicative ability of cancer cells and represent putative targets for G…
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2009
2009
Induction of G2/M arrest by pseudolaric acid B is mediated by activation of the ATM signaling pathway
A. Meng
,
Ling-ling Jiang
Acta Pharmacologica Sinica
2009
Corpus ID: 16682968
AbstractAim:The aim of this study was to investigate the mechanism of pseudolaric acid B (PLAB)-induced cell cycle arrest in…
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2008
2008
Activation of ATM signaling pathway is involved in oxidative stress-induced expression of mito-inhibitory p21WAF1/Cip1 in chronic non-suppurative destructive cholangitis in primary biliary cirrhosis…
M. Sasaki
,
H. Ikeda
,
Y. Nakanuma
Journal of Autoimmunity
2008
Corpus ID: 37266543
2006
2006
Oncogenes and the DNA Damage Response: Myc and E2F1 Engage the ATM Signaling Pathway to Activate p53 and Induce Apoptosis
Sungki Hong
,
R. Pusapati
,
John T. Powers
,
David G Johnson
Cell Cycle
2006
Corpus ID: 1385157
Activation of the ATM DNA damage response pathway is commonly observed in avariety of early-stage neoplasias. It has been…
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Highly Cited
2006
Highly Cited
2006
Indole‐3‐carbinol activates the ATM signaling pathway independent of DNA damage to stabilize p53 and induce G1 arrest of human mammary epithelial cells
C. Brew
,
I. Aronchik
,
+4 authors
G. Firestone
International Journal of Cancer
2006
Corpus ID: 22137693
The phytochemical indole‐3‐carbinol (I3C), from cruciferous vegetables such as broccoli, has been shown to elicit a potent anti…
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Highly Cited
2004
Highly Cited
2004
E2F1 uses the ATM signaling pathway to induce p53 and Chk2 phosphorylation and apoptosis.
John T. Powers
,
Sungki Hong
,
C. Mayhew
,
P. Rogers
,
E. Knudsen
,
David G Johnson
Molecular Cancer Research
2004
Corpus ID: 22775033
The p53 tumor suppressor protein is phosphorylated and activated by several DNA damage-inducible kinases, such as ATM, and is a…
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Highly Cited
2001
Highly Cited
2001
The yeast Xrs2 complex functions in S phase checkpoint regulation.
D. D'Amours
,
S. Jackson
Genes & Development
2001
Corpus ID: 23531870
The Nbs1 complex is an evolutionarily conserved multisubunit nuclease composed of the Mre11, Rad50, and Nbs1 proteins…
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