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ATM Signaling Pathway

The ataxia telangiectasia-mutated gene (ATM) encodes a protein kinase that acts as a tumor suppressor. ATM activation by ionizing radiation damage to… Expand
National Institutes of Health

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34 relations
ABL1 wt AlleleATM protein, humanATM wt AlleleATRIP protein, human
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Papers overview

Semantic Scholar uses AI to extract papers important to this topic.
2015
2015
Sodium glycididazole enhances the radiosensitivity of laryngeal cancer cells through downregulation of ATM signaling pathway
The purpose of this study was to evaluate the radiation-enhancing effect of sodium glycididazole, and the corresponding… Expand
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2012
2012
Competition between NBS1 and ATMIN controls ATM signaling pathway choice.
Ataxia telangiectasia mutated (ATM) protein kinase activation by DNA double-strand breaks (DSBs) requires the Mre11-Rad50-NBS1… Expand
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2011
2011
Autophagy inhibition enhances apoptosis triggered by BO-1051, an N-mustard derivative, and involves the ATM signaling pathway.
In a previous study, BO-1051, an N-mustard linked with a DNA-affinic molecule, was shown to target various types of cancer cell… Expand
Highly Cited
2009
Highly Cited
2009
Stabilization of quadruplex DNA perturbs telomere replication leading to the activation of an ATR-dependent ATM signaling pathway
Functional telomeres are required to maintain the replicative ability of cancer cells and represent putative targets for G… Expand
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2009
2009
Induction of G2/M arrest by pseudolaric acid B is mediated by activation of the ATM signaling pathway
AbstractAim:The aim of this study was to investigate the mechanism of pseudolaric acid B (PLAB)-induced cell cycle arrest in… Expand
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2008
2008
Activation of ATM signaling pathway is involved in oxidative stress-induced expression of mito-inhibitory p21WAF1/Cip1 in chronic non-suppurative destructive cholangitis in primary biliary cirrhosis…
Biliary epithelial cells (BECs) of chronic non-suppurative destructive cholangitis (CNSDC) in primary biliary cirrhosis (PBC… Expand
2006
2006
Oncogenes and the DNA Damage Response: Myc and E2F1 Engage the ATM Signaling Pathway to Activate p53 and Induce Apoptosis
Activation of the ATM DNA damage response pathway is commonly observed in avariety of early-stage neoplasias. It has been… Expand
Highly Cited
2006
Highly Cited
2006
Indole‐3‐carbinol activates the ATM signaling pathway independent of DNA damage to stabilize p53 and induce G1 arrest of human mammary epithelial cells
The phytochemical indole‐3‐carbinol (I3C), from cruciferous vegetables such as broccoli, has been shown to elicit a potent anti… Expand
Highly Cited
2004
Highly Cited
2004
E2F1 uses the ATM signaling pathway to induce p53 and Chk2 phosphorylation and apoptosis.
The p53 tumor suppressor protein is phosphorylated and activated by several DNA damage-inducible kinases, such as ATM, and is a… Expand
Highly Cited
2001
Highly Cited
2001
The yeast Xrs2 complex functions in S phase checkpoint regulation.
The Nbs1 complex is an evolutionarily conserved multisubunit nuclease composed of the Mre11, Rad50, and Nbs1 proteins… Expand
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