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ABL1 wt Allele

Known as: JTK7, c-ABL, v-Abl Abelson Murine Leukemia Viral Oncogene Homolog 1 wt Allele 
Human ABL1 wild-type allele is located in the vicinity of 9q34.1 and is approximately 173 kb in length. This allele, which encodes proto-oncogene… 
National Institutes of Health

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24 relations
9q34.1ABL1 geneATM Signaling PathwayApoptosis

Papers overview

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Highly Cited
2005
Highly Cited
2005
JNK phosphorylation of 14-3-3 proteins regulates nuclear targeting of c-Abl in the apoptotic response to DNA damage
The ubiquitously expressed c-Abl tyrosine kinase localizes to the cytoplasm and nucleus. Nuclear c-Abl is activated by diverse… 
Highly Cited
2003
Highly Cited
2003
Specific inhibition of bcr-abl gene expression by small interfering RNA.
Small interfering RNAs (siRNAs) were designed to target the bcr-abl oncogene, which causes chronic myeloid leukemia (CML) and bcr… 
Highly Cited
2002
Highly Cited
2002
DNA damage-dependent acetylation of p73 dictates the selective activation of apoptotic target genes.
Review
2000
Review
2000
Regulation of cell death by the Abl tyrosine kinase
The c-abl proto-oncogene encodes a protein tyrosine kinase that is distributed in the nucleus and the cytoplasm of proliferating… 
Highly Cited
1994
Highly Cited
1994
The nuclear tyrosine kinase c-abl negatively regulates cell growth
Highly Cited
1993
Highly Cited
1993
An actin‐binding function contributes to transformation by the Bcr‐Abl oncoprotein of Philadelphia chromosome‐positive human leukemias.
In Philadelphia chromosome‐positive human leukemias, which include chronic myelogenous leukemia and some acute lymphocytic… 
Highly Cited
1992
Highly Cited
1992
Identification of a protein that binds to the SH3 region of Abl and is similar to Bcr and GAP-rho.
A Src homology 3 (SH3) region is a sequence of approximately 50 amino acids found in many nonreceptor tyrosine kinases and other… 
Highly Cited
1991
Highly Cited
1991
BCR first exon sequences specifically activate the BCR/ABL tyrosine kinase oncogene of Philadelphia chromosome-positive human leukemias
The c-abl proto-oncogene encodes a cytoplasmic tyrosine kinase which is homologous to the src gene product in its kinase domain… 
Highly Cited
1991
Highly Cited
1991
Activation of tyrosinase kinase and microfilament-binding functions of c-abl by bcr sequences in bcr/abl fusion proteins
Chronic myelogenous leukemia and one type of acute lymphoblastic leukemia are characterized by a 9;22 chronosome translocation in… 
Highly Cited
1986
Highly Cited
1986
Sequential expression of protooncogenes during lectin-stimulated mitogenesis of normal human lymphocytes.
The proliferation of non-neoplastic T lymphocytes is regulated, in part, by the coordinated expression of genes encoding T-cell… 
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