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ABL1 wt Allele

Known as: JTK7, c-ABL, v-Abl Abelson Murine Leukemia Viral Oncogene Homolog 1 wt Allele 
Human ABL1 wild-type allele is located in the vicinity of 9q34.1 and is approximately 173 kb in length. This allele, which encodes proto-oncogene… 
National Institutes of Health

Related topics

Related topics

24 relations
9q34.1ABL1 geneATM Signaling PathwayApoptosis

Papers overview

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Review
2005
Review
2005
Enabling Death by the Abl Tyrosine Kinase: Mechanisms for Nuclear Shuttling of c-Abl in Response to DNA Damage
c-Abl is a ubiquitously expressed tyrosine kinase that participates in a diverse array of cellular signaling cascades. The… 
Highly Cited
2004
Highly Cited
2004
Imatinib sensitizes CLL lymphocytes to chlorambucil
The effect of imatinib on chlorambucil (CLB) cytotoxicity in chronic lymphocytic leukemia (CLL) lymphocytes was examined in vitro… 
Highly Cited
1999
Highly Cited
1999
c-Abl-induced apoptosis, but not cell cycle arrest, requires mitogen-activated protein kinase kinase 6 activation.
c-Abl is a ubiquitously expressed protein tyrosine kinase activated by DNA damage and implicated in two responses: cell cycle… 
Highly Cited
1996
Highly Cited
1996
Identification of a binding site in c-Ab1 tyrosine kinase for the C-terminal repeated domain of RNA polymerase II
The c-abl proto-oncogene encodes a nuclear tyrosine kinase that can phosphorylate the mammalian RNA polymerase II (RNAP II) on… 
Review
1988
Review
1988
Molecular biology of chronic myelogenous leukemia.
In this review we have described molecular consequences of the t(9;22) translocation typical of CML and some cases of ALL. This… 
Highly Cited
1987
Highly Cited
1987
Nucleotide sequence of testis-derived c-abl cDNAs: implications for testis-specific transcription and abl oncogene activation.
The c-abl gene codes for a protein-tyrosine kinase and is expressed in most examined murine cell types as two distinct mRNA… 
1986
1986
Induction of growth alterations in factor-dependent hematopoietic progenitor cell lines by cocultivation with irradiated bone marrow stromal cell lines.
We studied the production of hemopoietins by x-irradiated plateau-phase cultures of cloned marrow stromal cell lines derived from… 
Highly Cited
1985
Highly Cited
1985
Translocation of c-abl to "masked" Ph in chronic myeloid leukemia.
Highly Cited
1983
Highly Cited
1983
Cellular RNA homologous to the Abelson murine leukemia virus transforming gene: expression and relationship to the viral sequence
To examine the expression of the cellular homolog of the Abelson murine leukemia virus transforming gene (the v-abl sequence), a… 
Highly Cited
1983
Highly Cited
1983
Homology between phosphotyrosine acceptor site of human c-abl and viral oncogene products
The human homologues of several independent viral oncogenes, each of which encodes tyrosine-specific protein kinases, have been… 
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