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NF-κB-dependent induction of microRNA miR-146, an inhibitor targeted to signaling proteins of innate immune responses
A role is proposed for miR-146 in control of Toll-like receptor and cytokine signaling through a negative feedback regulation loop involving down-regulation of IL-1 receptor-associated kinase 1 and TNF receptor- associated factor 6 protein levels. Expand
Germline Transmission and Tissue-Specific Expression of Transgenes Delivered by Lentiviral Vectors
Transgenic mice carrying the green fluorescent protein (GFP) gene driven by a ubiquitously expressing promoter are generated and transgenic rats that express GFP at high levels are generated, suggesting that this technique can be used to produce other transgenic animal species. Expand
A new DNA binding and dimerization motif in immunoglobulin enhancer binding, daughterless, MyoD, and myc proteins
Two cDNAs were isolated whose dimerized products bind specifically to a DNA sequence, kappa E2, located in the immunoglobulin kappa chain enhancer, which plays a crucial role in both dimerization and DNA binding. Expand
MicroRNA-155 is induced during the macrophage inflammatory response
This study uses microarray technology to identify miRNAs induced in primary murine macrophages after exposure to polyriboinosinic:polyribocytidylic acid or the cytokine IFN-β and characterize miR-155 as a common target of a broad range of inflammatory mediators. Expand
Production of high-titer helper-free retroviruses by transient transfection.
The generation of high-titer, helper-free retroviruses by transient transfection has been achieved by using the highly transfectable 293T cell line into which are stably introduced constructs thatExpand
The IkappaB-NF-kappaB signaling module: temporal control and selective gene activation.
The model demonstrates that IkappaBalpha is responsible for strong negative feedback that allows for a fast turn-off of the NF-kappaB response, whereas IkappaBbeta and - epsilon function to reduce the system's oscillatory potential and stabilize NF- kappaB responses during longer stimulations. Expand
Daxx, a Novel Fas-Binding Protein That Activates JNK and Apoptosis
Daxx and FADD define two distinct apoptotic pathways downstream of Fas, which are sensitive to both Bcl-2 and dominant-negative JNK pathway components and acts cooperatively with the FADD pathway. Expand
An Essential Role for NF-κB in Preventing TNF-α-Induced Cell Death
Reintroduction of RelA into RelA−/− fibroblasts resulted in enhanced survival, demonstrating that the presence ofrelA is required for protection from TNF-α. Expand
RAG-1 and RAG-2, adjacent genes that synergistically activate V(D)J recombination.
The vast repertoire of immunoglobulins and T cell receptors is generated, in part, by V(D)J recombination, a series of genomic rearrangements that occur specifically in developing lymphocytes. TheExpand
The IκB-NF-κB Signaling Module: Temporal Control and Selective Gene Activation
A computational model is presented that describes the temporal control of NF-κB activation by the coordinated degradation and synthesis of IκB proteins and demonstrates that IπκBα is responsible for strong negative feedback that allows for a fast turn-off of the NF-σB response. Expand