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UTX and JMJD3 are histone H3K27 demethylases involved in HOX gene regulation and development
The trithorax and the polycomb group proteins are chromatin modifiers, which play a key role in the epigenetic regulation of development, differentiation and maintenance of cell fates. The polycomb… Expand
ALL-1 is a histone methyltransferase that assembles a supercomplex of proteins involved in transcriptional regulation.
ALL-1 is a member of the human trithorax/Polycomb gene family and is also involved in acute leukemia. ALL-1 is present within a stable, very large multiprotein supercomplex composed of > or =29… Expand
A histone H3 lysine 27 demethylase regulates animal posterior development
The recent discovery of a large number of histone demethylases suggests a central role for these enzymes in regulating histone methylation dynamics. Histone H3K27 trimethylation (H3K27me3) has been… Expand
Knockdown of ALR (MLL2) Reveals ALR Target Genes and Leads to Alterations in Cell Adhesion and Growth
- I. Issaeva, Yulia Zonis, +6 authors E. Canaani
- Medicine, Biology
- Molecular and Cellular Biology
- 18 December 2006
ABSTRACT ALR (MLL2) is a member of the human MLL family, which belongs to a larger SET1 family of histone methyltransferases. We found that ALR is present within a stable multiprotein complex… Expand
The t(4;11) chromosome translocation of human acute leukemias fuses the ALL-1 gene, related to Drosophila trithorax, to the AF-4 gene
The ALL-1 gene located at human chromosome 11 band q23 is rearranged in acute leukemias with interstitial deletions or reciprocal translocations between this region and chromosomes 1, 4, 6, 9, 10, or… Expand
Global and Hox-specific roles for the MLL1 methyltransferase.
- M. Guenther, R. Jenner, +4 authors R. Young
- Biology, Medicine
- Proceedings of the National Academy of Sciences…
- 14 June 2005
The mixed-lineage leukemia (MLL1/ALL-1/HRX) histone methyltransferase is involved in the epigenetic maintenance of transcriptional memory and the pathogenesis of human leukemias. To understand its… Expand
Fused transcript of abl and bcr genes in chronic myelogenous leukaemia
Human chronic myelogenous leukaemia is characterized by a reciprocal translocation between chromosomes 9 and 22 resulting in an abbreviated form of chromosome 22 and the transfer of the abl cellular… Expand
Aberrant chromatin at genes encoding stem cell regulators in human mixed-lineage leukemia.
Mixed-lineage leukemia (MLL) fusion proteins are potent inducers of leukemia, but how these proteins generate aberrant gene expression programs is poorly understood. Here we show that the MLL-AF4… Expand
Trithorax and dCBP Acting in a Complex to Maintain Expression of a Homeotic Gene
Trithorax (Trx) is a member of the trithorax group (trxG) of epigenetic regulators, which is required to maintain active states of Hox gene expression during development. We have purified from… Expand
Modulation of heat shock gene expression by the TAC1 chromatin-modifying complex
Rapid induction of the Drosophila melanogaster heat shock gene hsp70 is achieved through the binding of heat shock factor (HSF) to heat shock elements (HSEs) located upstream of the transcription… Expand