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Activation of the TrkB Neurotrophin Receptor Is Induced by Antidepressant Drugs and Is Required for Antidepressant-Induced Behavioral Effects
TLDR
The data suggest that antidepressants acutely increase trkB signaling in a BDNF-dependent manner in cerebral cortex and that this signaling is required for the behavioral effects typical of antidepressant drugs. Expand
The p75 Neurotrophin Receptor Mediates Neuronal Apoptosis and Is Essential for Naturally Occurring Sympathetic Neuron Death
TLDR
It is shown that p75NTR can signal to mediate apoptosis, and that this mechanism is essential for naturally occurring sympathetic neuron death, which is intrinsic to sympathetic neurons. Expand
P53 Is Essential for Developmental Neuron Death as Regulated by the TrkA and p75 Neurotrophin Receptors
TLDR
It is demonstrated that the p53 tumor suppressor protein is an essential component of both of these apoptotic signaling cascades that converge on the MEKK-JNK pathway to regulate the developmental death of sympathetic neurons. Expand
Functionally Antagonistic Interactions between the TrkA and p75 Neurotrophin Receptors Regulate Sympathetic Neuron Growth and Target Innervation
TLDR
Evidence is provided that BDNF, made by sympathetic neurons and/or their target organs, acts via p75NTR to antagonize NGF-mediated growth and target innervation, suggesting that sympathetic target Innervation is determined by the balance of positively and negatively acting neurotrophins present in developing and potentially mature targets. Expand
Ras Regulates Sympathetic Neuron Survival by Suppressing the p53-Mediated Cell Death Pathway
TLDR
Ras is, in part, both necessary and sufficient for survival of sympathetic neurons and that this effect is mediated by activation of both the PI3-K– and MEK-signaling cascades, which in turn suppress a proapoptotic p53 pathway. Expand
Synaptic Innervation Density Is Regulated by Neuron-Derived BDNF
TLDR
Results indicate that variations in neuronal neurotrophin synthesis directly regulate neuronal circuitry by selectively modulating synaptic innervation density. Expand
Transgenic Mice Expressing the Intracellular Domain of the p75 Neurotrophin Receptor Undergo Neuronal Apoptosis
TLDR
Biochemical analyses suggest that the p75NTR intracellular domain may act as a constitutive activator of signaling cascades that regulate apoptosis in both peripheral and central neurons. Expand
Evidence That Helix-Loop-Helix Proteins Collaborate with Retinoblastoma Tumor Suppressor Protein to Regulate Cortical Neurogenesis
TLDR
It is proposed that retinoblastoma tumor suppressor protein (pRb) collaborates with basic helix-loop-helix (bHLH) transcription factors to regulate cortical neurogenesis, taking advantage of the naturally occurring dominant-inhibitory HLH protein Id2. Expand
Oncolytic activity of vesicular stomatitis virus in primary adult T-cell leukemia
TLDR
The findings provide the first essential information for the development of a VSV-based treatment for ATL, emphasizing the concept that VSV targets genetic defects unique to tumor cells to facilitate its replication. Expand
Functional Evidence that BDNF Is an Anterograde Neuronal Trophic Factor in the CNS
TLDR
Results indicate that BDNF is anterogradely transported to fibers and terminals of noradrenergic neurons, that anterogsradely secreted BDNF causes activation of TrkB in target regions, and that this secretion has functional consequences for target neuron survival and differentiation. Expand
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