The DNA-damage response in human biology and disease
- S. Jackson, J. Bartek
- BiologyNature
- 22 October 2009
The authors' improving understanding of DNA-damage responses is providing new avenues for disease management, and these responses are biologically significant because they prevent diverse human diseases.
RNF8 Ubiquitylates Histones at DNA Double-Strand Breaks and Promotes Assembly of Repair Proteins
- N. Mailand, S. Bekker-Jensen, J. Lukas
- BiologyCell
- 30 November 2007
Cell-cycle checkpoints and cancer
All life on earth must cope with constant exposure to DNA-damaging agents such as the Sun's radiation, and how cells respond to DNA damage are critical determinants of whether that individual will develop cancer.
Human CtIP promotes DNA end resection
- A. Sartori, C. Lukas, S. Jackson
- BiologyNature
- 22 November 2007
These findings establish evolutionarily conserved roles for CtIP-like proteins in controlling DSB resection, checkpoint signalling and homologous recombination.
DNA damage response as a candidate anti-cancer barrier in early human tumorigenesis
- J. Bártková, Z. HoÅ™ejÅ¡Ã, J. Bartek
- BiologyNature
- 14 April 2005
It is shown that in clinical specimens from different stages of human tumours of the urinary bladder, breast, lung and colon, the early precursor lesions commonly express markers of an activated DNA damage response.
RNF168 Binds and Amplifies Ubiquitin Conjugates on Damaged Chromosomes to Allow Accumulation of Repair Proteins
- C. Doil, N. Mailand, C. Lukas
- BiologyCell
- 6 February 2009
ATM- and cell cycle-dependent regulation of ATR in response to DNA double-strand breaks
- A. Jazayeri, J. Falck, S. Jackson
- BiologyNature Cell Biology
- 2006
It is shown that ATM and the nuclease activity of meiotic recombination 11 are required for the processing of DNA double-strand breaks (DSBs) to generate the replication protein A (RPA)-coated ssDNA that is needed for ATR recruitment and the subsequent phosphorylation and activation of Chk1.
The ATM–Chk2–Cdc25A checkpoint pathway guards against radioresistant DNA synthesis
- J. Falck, N. Mailand, R. Syljuåsen, J. Bartek, J. Lukas
- BiologyNature
- 12 April 2001
A functional link between ATM, the checkpoint signalling kinase Chk2/Cds1 (Chk2) and Cdc25A is reported, and this mechanism in controlling the S-phase checkpoint is identified as a genomic integrity checkpoint that prevents radioresistant DNA synthesis.
Chromatin relaxation in response to DNA double-strand breaks is modulated by a novel ATM- and KAP-1 dependent pathway
- Y. Ziv, D. Bielopolski, Y. Shiloh
- BiologyNature Cell Biology
- 23 July 2006
It is shown that DSB formation is followed by ATM-dependent chromatin relaxation, which suggests that chromatin Relaxation is a fundamental pathway in the DNA-damage response and identifies its primary mediators.
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