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Staurosporine

Known as: Staurosporine [Chemical/Ingredient], (9alpha,10beta,11beta,13alpha)-(+)-2,3,10,11,12,13-Hexahydro-10-methoxy-9-methyl-11-(methylamino)-9,13-epoxy-1H-9H-diindolo[1,2,3-gh:3',2',1'-lm]pyrrolo[3,4-j][1,7]benzodiazonin-1-one, CGP-39360 
A cell permeable alkaloid isolated from Streptomyces staurosporeus exhibiting anti-cancer activity. Staurosporine is a potent, non-selective… 
National Institutes of Health

Related topics

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31 relations

Narrower (17)

3'-demethoxy-3'-hydroxystaurosporine4'-demethylamino-4'-hydroxystaurosporine5'-hydroxystaurosporine7-O-methyl-UCN 01

Broader (2)

AlkaloidsEnzyme Inhibitors
Antineoplastic AgentsIn BloodNCIt Antineoplastic Agent TerminologyProcess of secretion

Papers overview

Semantic Scholar uses AI to extract papers important to this topic.
Highly Cited
1993
Highly Cited
1993
Expression of an oncogenic rasHa gene in murine keratinocytes induces tyrosine phosphorylation and reduced activity of protein kinase C delta.
Highly Cited
1993
Highly Cited
1993
Differential inhibition of multiple vesicular transport steps between the endoplasmic reticulum and trans Golgi network.
Highly Cited
1993
Highly Cited
1993
Protein kinase C is activated in platelets subjected to pathological shear stress.
Highly Cited
1992
Highly Cited
1992
Interleukin 1 induces NF-kappa B through its type I but not its type II receptor in lymphocytes.
Highly Cited
1992
Highly Cited
1992
The cytoplasmic domain of tissue factor is phosphorylated by a protein kinase C-dependent mechanism.
Highly Cited
1991
Highly Cited
1991
Collagen-induced exposure of anionic phospholipid in platelets and platelet-derived microparticles.
Highly Cited
1991
Highly Cited
1991
T-cell antigen receptor ligation induces tyrosine phosphorylation of phospholipase C-gamma 1.
Highly Cited
1990
Highly Cited
1990
Expression, purification, and characterization of protein kinase C-epsilon.
Highly Cited
1989
Highly Cited
1989
Regulation of muscle AChR α subunit gene expression by electrical activity: Involvement of protein kinase C and Ca 2+
Highly Cited
1988
Highly Cited
1988
A role for Gi in control of thrombin receptor-phospholipase C coupling in human platelets.
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