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Staurosporine

Known as: Staurosporine [Chemical/Ingredient], (9alpha,10beta,11beta,13alpha)-(+)-2,3,10,11,12,13-Hexahydro-10-methoxy-9-methyl-11-(methylamino)-9,13-epoxy-1H-9H-diindolo[1,2,3-gh:3',2',1'-lm]pyrrolo[3,4-j][1,7]benzodiazonin-1-one, CGP-39360 
A cell permeable alkaloid isolated from Streptomyces staurosporeus exhibiting anti-cancer activity. Staurosporine is a potent, non-selective… Expand
National Institutes of Health

Papers overview

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Highly Cited
2005
Highly Cited
2005
Mitochondria play a critical role in mediating both apoptotic and necrotic cell death. The mitochondrial permeability transition… Expand
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Highly Cited
2001
Highly Cited
2001
Multiple death signals influence mitochondria during apoptosis, yet the critical initiating event for mitochondrial dysfunction… Expand
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Highly Cited
2001
Highly Cited
2001
Sensitivity of tumor cells to anticancer therapy depends on the ability of the drug to induce apoptosis. However, multiple… Expand
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Highly Cited
2000
Highly Cited
2000
The specific phosphoinositide 3-kinase (PI3K) inhibitors wortmannin and LY294002 have been invaluable tools for elucidating the… Expand
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Highly Cited
2000
Highly Cited
2000
Apoptosis, or cellular suicide, is important for normal development and tissue homeostasis, but too much or too little apoptosis… Expand
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Highly Cited
1998
Highly Cited
1998
The bacterial alkaloid staurosporine is widely employed as an inducer of apoptosis in many cell types including neurons. The… Expand
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Highly Cited
1998
Highly Cited
1998
Interleukin 1β-converting enzyme-like proteases (caspases) are crucial components of cell death pathways. Among the caspases… Expand
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Highly Cited
1994
Highly Cited
1994
The present observations show that staurosporine can rapidly trigger both the morphological changes and intranucleosomal DNA… Expand
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Highly Cited
1991
Highly Cited
1991
Staurosporine is the most potent inhibitor of protein kinase C (PKC) described in the literature with a half-maximal inhibitory… Expand
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Highly Cited
1986
Highly Cited
1986
Staurosporine, microbial alkaloid which has been known to have antifungal activity was found to inhibit markedly phospholipid/Ca… Expand
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