Staurosporine

Known as: Staurosporine [Chemical/Ingredient], (9alpha,10beta,11beta,13alpha)-(+)-2,3,10,11,12,13-Hexahydro-10-methoxy-9-methyl-11-(methylamino)-9,13-epoxy-1H-9H-diindolo[1,2,3-gh:3',2',1'-lm]pyrrolo[3,4-j][1,7]benzodiazonin-1-one, CGP-39360 
A cell permeable alkaloid isolated from Streptomyces staurosporeus exhibiting anti-cancer activity. Staurosporine is a potent, non-selective… (More)
National Institutes of Health

Papers overview

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Highly Cited
2004
Highly Cited
2004
Staurosporine has long been used in vitro as an initiator of apoptosis in many different cell types, but the mechanism involved… (More)
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Highly Cited
2003
Highly Cited
2003
Apoptosis provoked by DNA damage requires the p53 tumor suppressor, but which of the many p53-regulated genes are required has… (More)
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Highly Cited
2001
Highly Cited
2001
Increased levels of DNA fragments have frequently been found in the blood plasma of cancer patients. Published data suggest that… (More)
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Highly Cited
2001
Highly Cited
2001
Sensitivity of tumor cells to anticancer therapy depends on the ability of the drug to induce apoptosis. However, multiple… (More)
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Highly Cited
2001
Highly Cited
2001
Incubation of endothelial cells in vitro with high concentrations of glucose activates protein kinase C (PKC) and increases… (More)
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Highly Cited
2000
Highly Cited
2000
The specific phosphoinositide 3-kinase (PI3K) inhibitors wortmannin and LY294002 have been invaluable tools for elucidating the… (More)
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Highly Cited
2000
Highly Cited
2000
Apoptosis, or cellular suicide, is important for normal development and tissue homeostasis, but too much or too little apoptosis… (More)
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Highly Cited
1998
Highly Cited
1998
Mitochondrial cytochrome c, which functions as an electron carrier in the respiratory chain, translocates to the cytosol in cells… (More)
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Highly Cited
1995
Highly Cited
1995
Staurosporine, a nonselective protein kinase inhibitor, has been shown to induce apoptosis in several different nonneuronal cell… (More)
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Highly Cited
1994
Highly Cited
1994
The present observations show that staurosporine can rapidly trigger both the morphological changes and intranucleosomal DNA… (More)
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