Skip to search formSkip to main contentSkip to account menu

Staurosporine

Known as: Staurosporine [Chemical/Ingredient], (9alpha,10beta,11beta,13alpha)-(+)-2,3,10,11,12,13-Hexahydro-10-methoxy-9-methyl-11-(methylamino)-9,13-epoxy-1H-9H-diindolo[1,2,3-gh:3',2',1'-lm]pyrrolo[3,4-j][1,7]benzodiazonin-1-one, CGP-39360 
A cell permeable alkaloid isolated from Streptomyces staurosporeus exhibiting anti-cancer activity. Staurosporine is a potent, non-selective… 
National Institutes of Health

Related topics

Related topics

31 relations

Narrower (17)

3'-demethoxy-3'-hydroxystaurosporine4'-demethylamino-4'-hydroxystaurosporine5'-hydroxystaurosporine7-O-methyl-UCN 01

Broader (2)

AlkaloidsEnzyme Inhibitors
Antineoplastic AgentsIn BloodNCIt Antineoplastic Agent TerminologyProcess of secretion

Papers overview

Semantic Scholar uses AI to extract papers important to this topic.
2004
2004
Signaling cascade of ANG II-induced inhibition of α-MG uptake in renal proximal tubule cells
ANG II and Na+-glucose cotransporter have been reported to be associated with the onset of diverse renal diseases. However, the… 
Highly Cited
2003
Highly Cited
2003
Cytometric analysis of protein expression and apoptosis in human primary cells with a novel microfluidic chip‐based system
Work with primary cells is inherently limited by source availability and life span in culture. Flow cytometry offers extensive… 
2002
2002
Defective Bax activation in Hodgkin B-cell lines confers resistance to staurosporine-induced apoptosis
Deregulated apoptosis represents an important hallmark of tumor cells. Here we investigated the induction of cell death signaling… 
Highly Cited
1998
Highly Cited
1998
Extracellular calcium influx stimulates metalloproteinase cleavage and secretion of heparin‐binding EGF‐like growth factor independently of protein kinase C
The phorbol ester, tetradecanoyl‐phorbol 13‐acetate (TPA), stimulates rapid proteolytic processing of the transmembrane, pro… 
1996
1996
Expression of the nucleoside triphosphate pyrophosphohydrolase PC‐1 is induced by basic fibroblast growth factor (bFGF) and modulated by activation of the protein kinase A and C pathways in…
The closely related cytokines bFGF and aFGF regulate the function of bone cells and mineralization. Osteoblasts express PPi… 
1993
1993
Inhibition of multidrug resistance by a new staurosporine derivative, NA-382, in vitro and in vivo.
The effects of a newly synthesized compound, N-ethoxycarbonyl-7-oxo-staurosporine (NA-382), on multidrug resistance in tumor… 
1993
1993
Stimulation of the human neutrophil respiratory burst by formyl peptides is primed by a protein kinase inhibitor, staurosporine.
Stimulation of polymorphonuclear neutrophils (PMN) by phorbol esters or formyl peptides (fMLP) generates large quantities of… 
Highly Cited
1992
Highly Cited
1992
Signal transduction mechanisms of C1q-mediated superoxide production. Evidence for the involvement of temporally distinct staurosporine-insensitive and sensitive pathways.
C1q, a plasma glycoprotein and the recognition component of the classical complement pathway, interacts with specific cells of… 
1992
1992
Staurosporine overrides checkpoints for mitotic onset in BHK cells.
Under normal conditions, mammalian cells will not initiate mitosis in the presence of either unreplicated or damaged DNA. We… 
Highly Cited
1988
Highly Cited
1988
Staurosporine, a novel protein kinase inhibitor, enhances HL-60-cell differentiation induced by various compounds.
The effect of staurosporine, a novel calcium/phospholipid-dependent protein kinase (protein kinase C) inhibitor, on… 
By clicking accept or continuing to use the site, you agree to the terms outlined in our Privacy Policy (opens in a new tab), Terms of Service (opens in a new tab), and Dataset License (opens in a new tab)