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Mitochondria play a critical role in mediating both apoptotic and necrotic cell death. The mitochondrial permeability transition… Expand Multiple death signals influence mitochondria during apoptosis, yet the critical initiating event for mitochondrial dysfunction… Expand Sensitivity of tumor cells to anticancer therapy depends on the ability of the drug to induce apoptosis. However, multiple… Expand Increased levels of DNA fragments have frequently been found in the blood plasma of cancer patients. Published data suggest that… Expand The specific phosphoinositide 3-kinase (PI3K) inhibitors wortmannin and LY294002 have been invaluable tools for elucidating the… Expand Apoptosis, or cellular suicide, is important for normal development and tissue homeostasis, but too much or too little apoptosis… Expand The bacterial alkaloid staurosporine is widely employed as an inducer of apoptosis in many cell types including neurons. The… Expand Interleukin 1β-converting enzyme-like proteases (caspases) are crucial components of cell death pathways. Among the caspases… Expand Staurosporine is the most potent inhibitor of protein kinase C (PKC) described in the literature with a half-maximal inhibitory… Expand Staurosporine, microbial alkaloid which has been known to have antifungal activity was found to inhibit markedly phospholipid/Ca… Expand