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Staurosporine

Known as: Staurosporine [Chemical/Ingredient], (9alpha,10beta,11beta,13alpha)-(+)-2,3,10,11,12,13-Hexahydro-10-methoxy-9-methyl-11-(methylamino)-9,13-epoxy-1H-9H-diindolo[1,2,3-gh:3',2',1'-lm]pyrrolo[3,4-j][1,7]benzodiazonin-1-one, CGP-39360 
A cell permeable alkaloid isolated from Streptomyces staurosporeus exhibiting anti-cancer activity. Staurosporine is a potent, non-selective… 
National Institutes of Health

Papers overview

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Highly Cited
2001
Highly Cited
2001
Multiple death signals influence mitochondria during apoptosis, yet the critical initiating event for mitochondrial dysfunction… 
Highly Cited
2001
Highly Cited
2001
Hyperglycemia is the major causal factor in the development of endothelial dysfunction in patients with diabetes mellitus… 
Highly Cited
2001
Highly Cited
2001
Sensitivity of tumor cells to anticancer therapy depends on the ability of the drug to induce apoptosis. However, multiple… 
Highly Cited
2000
Highly Cited
2000
Apoptosis, or cellular suicide, is important for normal development and tissue homeostasis, but too much or too little apoptosis… 
Highly Cited
1994
Highly Cited
1994
The present observations show that staurosporine can rapidly trigger both the morphological changes and intranucleosomal DNA… 
Highly Cited
1991
Highly Cited
1991
Highly Cited
1986