Skip to search formSkip to main content
You are currently offline. Some features of the site may not work correctly.

Staurosporine

Known as: Staurosporine [Chemical/Ingredient], (9alpha,10beta,11beta,13alpha)-(+)-2,3,10,11,12,13-Hexahydro-10-methoxy-9-methyl-11-(methylamino)-9,13-epoxy-1H-9H-diindolo[1,2,3-gh:3',2',1'-lm]pyrrolo[3,4-j][1,7]benzodiazonin-1-one, CGP-39360 
A cell permeable alkaloid isolated from Streptomyces staurosporeus exhibiting anti-cancer activity. Staurosporine is a potent, non-selective… Expand
National Institutes of Health

Papers overview

Semantic Scholar uses AI to extract papers important to this topic.
Highly Cited
2005
Highly Cited
2005
Mitochondria play a critical role in mediating both apoptotic and necrotic cell death. The mitochondrial permeability transition… Expand
  • figure 1
  • figure 2
  • figure 3
  • figure 4
Highly Cited
2001
Highly Cited
2001
Multiple death signals influence mitochondria during apoptosis, yet the critical initiating event for mitochondrial dysfunction… Expand
Highly Cited
2001
Highly Cited
2001
Sensitivity of tumor cells to anticancer therapy depends on the ability of the drug to induce apoptosis. However, multiple… Expand
  • figure 1
  • figure 2
  • figure 3
  • figure 5
  • figure 4
Highly Cited
2001
Highly Cited
2001
Increased levels of DNA fragments have frequently been found in the blood plasma of cancer patients. Published data suggest that… Expand
  • table 1
  • figure 1
  • figure 2
  • figure 4
  • figure 3
Highly Cited
2000
Highly Cited
2000
The specific phosphoinositide 3-kinase (PI3K) inhibitors wortmannin and LY294002 have been invaluable tools for elucidating the… Expand
  • figure 2
  • figure 1
  • figure 3
  • figure 4
  • figure 6
Highly Cited
2000
Highly Cited
2000
  • T. Nakagawa, Hong Zhu, +4 authors Junying Yuan
  • Nature
  • 2000
  • Corpus ID: 205065930
Apoptosis, or cellular suicide, is important for normal development and tissue homeostasis, but too much or too little apoptosis… Expand
  • figure 1
  • figure 2
  • figure 3
  • figure 4
  • figure 5
Highly Cited
1998
Highly Cited
1998
The bacterial alkaloid staurosporine is widely employed as an inducer of apoptosis in many cell types including neurons. The… Expand
Highly Cited
1998
Highly Cited
1998
Interleukin 1β-converting enzyme-like proteases (caspases) are crucial components of cell death pathways. Among the caspases… Expand
Highly Cited
1991
Highly Cited
1991
Staurosporine is the most potent inhibitor of protein kinase C (PKC) described in the literature with a half-maximal inhibitory… Expand
Highly Cited
1986
Highly Cited
1986
Staurosporine, microbial alkaloid which has been known to have antifungal activity was found to inhibit markedly phospholipid/Ca… Expand