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Negative Regulation of G1 to S Transition

Known as: G1-S Arrest, G1/S Arrest 
G1-S Arrest consists of cellular biochemical mechanisms, responsive to diverse governing conditions (DNA damage, contact inhibition, growth factors… 
National Institutes of Health

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7-hydroxystaurosporineAd5CMV-p53 geneCell ProliferationG1 to S Transition Process

Papers overview

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2014
2014
Inhibition of Rac 1 activity induces G 1 / S phase arrest through the GSK 3 / cyclin D 1 pathway in human cancer cells
Rac1 has been shown to regulate the cell cycle in cancer cells. Yet, the related mechanism remains unclear. Thus, the present… 
2014
2014
Knock-down of ABCE 1 gene induces G 1 / S arrest in human oral cancer cells
Purpose: This study aims to explore the clinical characteristics of ATP binding cassette E1 (ABCE1) in oral squamous cell… 
2013
2013
The RASSF 6 Tumor Suppressor Protein Regulates Apoptosis and the Cell Cycle via MDM 2 Protein and p 53 Protein *
Ras association domain family (RASSF) 6 is a member of the C-terminal RASSF proteins such as RASSF1A and RASSF3. RASSF6 is… 
2005
2005
p 53-mediated cellular response to DNA damage in cells with replicative hepatitis B virus ( tumor suppressor gene / p 21 CIPl / wAFl / DNA-damaging agent / viral carcinogenesis )
Wild-type p53 acts as a tumor suppressor gene by protecting cells from deleterious effects of genotoxic agents through the… 
2005
2005
[E1A oncogene effect on the ability of p21(Waf1) to regulate G1/S arrest in E1A-expressing transformants following irradiation].
P21(Waf1) cyclin-dependent kinase inhibitor blocks cell cycle transition from G1 phase into DNA replication after DNA damage. The…