Skip to search formSkip to main contentSkip to account menu

UCN 01

Known as: (+)-UCN-01, UCN-01 
National Institutes of Health

Related topics

Related topics

1 relation

Broader (1)

7-hydroxystaurosporine

Papers overview

Semantic Scholar uses AI to extract papers important to this topic.
2007
2007
ATR signaling mediates an S-phase checkpoint after inhibition of poly(ADP-ribose) polymerase activity.
Highly Cited
2006
Highly Cited
2006
Phase I trial of UCN-01 in combination with topotecan in patients with advanced solid cancers: a Princess Margaret Hospital Phase II Consortium study.
BACKGROUND 7-Hydroxystaurosporine (UCN-01) inhibits serine-threonine kinases including the Ca2+ and phospholipid-dependent… 
Highly Cited
2005
Highly Cited
2005
A phase I and pharmacokinetic study of short infusions of UCN-01 in patients with refractory solid tumors.
Purpose: To define the maximum tolerated dose and the dose-limiting toxicity of the kinase modulator UCN-01 administered as a… 
Highly Cited
2005
Highly Cited
2005
Phase I trial of the cyclin-dependent kinase inhibitor and protein kinase C inhibitor 7-hydroxystaurosporine in combination with Fluorouracil in patients with advanced solid tumors.
PURPOSE Preclinical studies indicate that the cyclin-dependent kinase and protein kinase C inhibitor 7-hydroxystaurosporine (UCN… 
2005
2005
Involvement of poly(ADP-ribose) polymerase activity in regulating Chk1-dependent apoptotic cell death.
2005
2005
The Farnesyltransferase Inhibitor L744832 Potentiates UCN-01–Induced Apoptosis in Human Multiple Myeloma Cells
Purpose: The purpose of this study was to characterize interactions between the farnesyltransferase inhibitor L744832 and the… 
Highly Cited
2004
Highly Cited
2004
7-Hydroxystaurosporine (UCN-01) Inhibition of Akt Thr308 but not Ser473 Phosphorylation
7-Hydroxystaurosporine (UCN-01) infused for 72 hours by continuous i.v. infusion induced insulin resistance during phase I… 
Highly Cited
2002
Highly Cited
2002
Abrogation of the S Phase DNA Damage Checkpoint Results in S Phase Progression or Premature Mitosis Depending on the Concentration of 7-Hydroxystaurosporine and the Kinetics of Cdc25C Activation*
DNA damage causes cell cycle arrest in G1, S, or G2 to prevent replication on damaged DNA or to prevent aberrant mitosis. The G1… 
2000
2000
Physiological Modeling of Altered Pharmacokinetics of a Novel Anticancer Drug, UCN-01 (7-Hydroxystaurosporine), Caused by Slow Dissociation of UCN-01 from Human α1-Acid Glycoprotein
AbstractPurpose. The extremely low clearance and small distribution volumeof UCN-01 in humans could be partly due to the high… 
1999
1999
Pharmacokinetics and pharmacodynamics of a novel protein kinase inhibitor, UCN-01
Purpose: 7-Hydroxystaurosporine (UCN-01) is a potent protein kinase inhibitor and is being developed as a novel anticancer agent… 
By clicking accept or continuing to use the site, you agree to the terms outlined in our Privacy Policy (opens in a new tab), Terms of Service (opens in a new tab), and Dataset License (opens in a new tab)