UCN 01

Known as: (+)-UCN-01, UCN-01 
 
National Institutes of Health

Papers overview

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Highly Cited
2004
Highly Cited
2004
Squamous carcinomas of the head and neck (HNSCC) represent the sixth most common cancer among men worldwide and a major cause of… (More)
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Highly Cited
2002
Highly Cited
2002
3-Phosphoinositide-dependent protein kinase-1 (PDK1) plays a central role in activating the AGC subfamily of protein kinases. In… (More)
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Highly Cited
2001
Highly Cited
2001
PURPOSE To define the maximum tolerated dose (MTD) and dose-limiting toxicity (DLT) of the novel protein kinase inhibitor, UCN-01… (More)
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Highly Cited
2000
Highly Cited
2000
A checkpoint operating in the G(2) phase of the cell cycle prevents entry into mitosis in the presence of DNA damage. UCN-01, a… (More)
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Highly Cited
2000
Highly Cited
2000
The investigational anticancer agent 7-hydroxystaurosporine (UCN-01) abrogates the G2 checkpoint in tumor cells and sensitizes… (More)
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Highly Cited
1999
Highly Cited
1999
Caffeine exposure sensitizes tumor cells to ionizing radiation and other genotoxic agents. The radiosensitizing effects of… (More)
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Highly Cited
1998
Highly Cited
1998
The pharmacokinetics of UCN-01 after administration as a 72- or 3-h infusion to cancer patients in initial Phase I trials… (More)
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Highly Cited
1996
Highly Cited
1996
BACKGROUND Arrest of the cell cycle in G2 phase following DNA damage helps protect cell viability by allowing time for DNA repair… (More)
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Highly Cited
1996
Highly Cited
1996
DNA-damaging agents arrest cell cycle progression at either G1 or G2. A variety of agents such as caffeine have been shown to… (More)
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Highly Cited
1991
Highly Cited
1991
Antitumor activity of UCN-01 (7-hydroxy staurosporine), a selective inhibitor of Ca2+- and phospholipid-dependent protein kinase… (More)
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