Author pages are created from data sourced from our academic publisher partnerships and public sources.
- Publications
- Influence
Share This Author
Membrane transporters in drug development
- K. Giacomini, Shiew-Mei Huang, Lei Zhang
- Biology, MedicineNature Reviews Drug Discovery
- 1 March 2010
TLDR
Prediction of pharmacokinetic alterations caused by drug-drug interactions: metabolic interaction in the liver.
- K. Ito, T. Iwatsubo, S. Kanamitsu, K. Ueda, H. Suzuki, Y. Sugiyama
- Medicine, BiologyPharmacological reviews
- 1 September 1998
Serious side-effects caused by drug interactions have attracted a great deal of attention and have become a social problem since the coadministration of ketoconazole and terfenadine was reported to…
Pharmacokinetic and pharmacodynamic alterations of 3-hydroxy-3-methylglutaryl coenzyme A (HMG-CoA) reductase inhibitors: drug-drug interactions and interindividual differences in transporter and…
- Y. Shitara, Y. Sugiyama
- Biology, ChemistryPharmacology & therapeutics
- 1 October 2006
Molecular Cloning and Characterization of a New Multispecific Organic Anion Transporter from Rat Brain*
- H. Kusuhara, T. Sekine, H. Endou
- Biology, ChemistryThe Journal of Biological Chemistry
- 7 May 1999
TLDR
Contribution of OATP2 (OATP1B1) and OATP8 (OATP1B3) to the Hepatic Uptake of Pitavastatin in Humans
- M. Hirano, K. Maeda, Y. Shitara, Y. Sugiyama
- Biology, ChemistryJournal of Pharmacology and Experimental…
- 1 October 2004
TLDR
Recent advances in 2D and 3D in vitro systems using primary hepatocytes, alternative hepatocyte sources and non-parenchymal liver cells and their use in investigating mechanisms of hepatotoxicity,…
- P. Godoy, N. Hewitt, J. Hengstler
- Biology, MedicineArchives of Toxicology
- 23 August 2013
TLDR
Involvement of Multiple Transporters in the Hepatobiliary Transport of Rosuvastatin
- S. Kitamura, K. Maeda, Yi Wang, Y. Sugiyama
- BiologyDrug Metabolism and Disposition
- 1 October 2008
Rosuvastatin is an HMG-CoA reductase inhibitor and one of the most hydrophilic among the commercially available statins. It is efficiently accumulated in the liver and excreted into the bile in an…
Prediction of in vivo drug metabolism in the human liver from in vitro metabolism data.
- T. Iwatsubo, N. Hirota, Y. Sugiyama
- Biology, MedicinePharmacology & therapeutics
- 1997
Gemfibrozil and Its Glucuronide Inhibit the Organic Anion Transporting Polypeptide 2 (OATP2/OATP1B1:SLC21A6)-Mediated Hepatic Uptake and CYP2C8-Mediated Metabolism of Cerivastatin: Analysis of the…
- Y. Shitara, M. Hirano, Hitoshi Sato, Y. Sugiyama
- Biology, ChemistryJournal of Pharmacology and Experimental…
- 1 October 2004
TLDR
Molecular Cloning and Characterization of Multispecific Organic Anion Transporter 4 Expressed in the Placenta*
TLDR
...
1
2
3
4
5
...