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tryptophan 5-monooxygenase activity

Known as: tryptophan hydroxylase activity, tryptophan 5-hydroxylase activity, L-tryptophan,tetrahydrobiopterin:oxygen oxidoreductase (5-hydroxylating) 
Catalysis of the reaction: L-tryptophan + tetrahydrobiopterin + O2 = 5-hydroxy-L-tryptophan + 4-alpha-hydroxytetrahydrobiopterin + H2O. [EC:1.14.16.4… 
National Institutes of Health

Papers overview

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Highly Cited
1989
Highly Cited
1989
Increase in the activity of tryptophan hydroxylase from cortex and midbrain of male Fischer 344 rats in response to acute or repeated sound stress
Highly Cited
1987
Highly Cited
1987
Depression of rat brain tryptophan hydroxylase activity following the acute administration of methylenedioxymethamphetamine.
Highly Cited
1985
Highly Cited
1985
Role of the dopamine uptake carrier in the neurochemical response to methamphetamine: effects of amfonelic acid.
Highly Cited
1976
Highly Cited
1976
Histologic and enzymatic studies of the mesolimbic and mesostriatal serotonergic pathways
Highly Cited
1975
Highly Cited
1975
Long-term effects of p-chloroamphetamine and related drugs on central serotonergic mechanisms.
Earlier studies from our laboratory have demonstrated a marked reduction in the brain level of 5-hydroxytryptamine (5-HT) and in… 
Highly Cited
1974
Highly Cited
1974
Adrenalcortical influence on rat brain tryptophan hydroxylase activity.
Highly Cited
1972
Highly Cited
1972
Long-term effects of p-chloroamphetamine on tryptophan hydroxylase activity and on the levels of 5-hydroxytryptamine and 5-hydroxyindole acetic acid in brain.
Highly Cited
1971
Highly Cited
1971
Selective reduction of tryptophan hydroxylase activity in rat forebrain after midbrain raphe lesions.
Highly Cited
1969
Highly Cited
1969
Corticosterone Regulation of Tryptophan Hydroxylase in Midbrain of the Rat
The tryptophan hydroxylase activity in the rat midbrain decreases after adrenalectomy and is restored by treatment with… 
Highly Cited
1967
Highly Cited
1967
The biosynthesis of 5-hydroxytryptamine in brain.
1. Studies on the anatomical distribution of tryptophan 5-hydroxylase in dog brain show that the activity of this enzyme… 
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