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tryptophan 5-monooxygenase activity

Known as: tryptophan hydroxylase activity, tryptophan 5-hydroxylase activity, L-tryptophan,tetrahydrobiopterin:oxygen oxidoreductase (5-hydroxylating) 
Catalysis of the reaction: L-tryptophan + tetrahydrobiopterin + O2 = 5-hydroxy-L-tryptophan + 4-alpha-hydroxytetrahydrobiopterin + H2O. [EC:1.14.16.4… Expand
National Institutes of Health

Papers overview

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Highly Cited
2007
Highly Cited
2007
The long-term effects on marine fish populations of the recent increase worldwide in the incidence of coastal hypoxia are unknown… Expand
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Highly Cited
1998
Highly Cited
1998
  • B. Yamamoto, W. Zhu
  • The Journal of pharmacology and experimental…
  • 1998
  • Corpus ID: 5448428
The effects of methamphetamine (METH) on pro-oxidant processes and on the production of reactive oxygen species were examined in… Expand
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Highly Cited
1987
Highly Cited
1987
The psychotomimetic agent, methylenedioxymethamphetamine, produced a rapid, persistent and dose-dependent reduction in cortical… Expand
Highly Cited
1977
Highly Cited
1977
Concentrations of serotonin and tryptophan hydroxylase activity in individual hypothalamic and limbic nuclei, as well as cortical… Expand
Highly Cited
1976
Highly Cited
1976
Selective lesions of the dorsal (B7), median (B8), or lateral (B9) raphe nuclei were made stereotaxically in male rats 4 weeks… Expand
Highly Cited
1975
Highly Cited
1975
Earlier studies from our laboratory have demonstrated a marked reduction in the brain level of 5-hydroxytryptamine (5-HT) and in… Expand
Highly Cited
1974
Highly Cited
1974
Abstract Tryptophan hydroxylase activity in the midbrain of the rat increases as a consequence of electric foot shock, ether… Expand
Highly Cited
1973
Highly Cited
1973
Short-term treatment with lithium chloride stimulates the uptake of tryptophan and its conversion to serotonin by striate… Expand
Highly Cited
1971
Highly Cited
1971
Summary We have found a selective reduction in forebrain tryptophan hydroxylase activity afer placement of electrolytic lesions… Expand
Highly Cited
1969
Highly Cited
1969
The tryptophan hydroxylase activity in the rat midbrain decreases after adrenalectomy and is restored by treatment with… Expand