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tryptophan 5-monooxygenase activity

Known as: tryptophan hydroxylase activity, tryptophan 5-hydroxylase activity, L-tryptophan,tetrahydrobiopterin:oxygen oxidoreductase (5-hydroxylating) 
Catalysis of the reaction: L-tryptophan + tetrahydrobiopterin + O2 = 5-hydroxy-L-tryptophan + 4-alpha-hydroxytetrahydrobiopterin + H2O. [EC:1.14.16.4… Expand
National Institutes of Health

Papers overview

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Highly Cited
2007
Highly Cited
2007
Widespread endocrine disruption and reproductive impairment in an estuarine fish population exposed to seasonal hypoxia
The long-term effects on marine fish populations of the recent increase worldwide in the incidence of coastal hypoxia are unknown… Expand
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2005
2005
Association between Tph2 gene polymorphism, brain tryptophan hydroxylase activity and aggressiveness in mouse strains.
The brain neurotransmitter serotonin is involved in the regulation of aggressive behavior. The main factor determining the brain… Expand
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2005
2005
Serotonin synthesis by two distinct enzymes in Drosophila melanogaster.
Annotation of the sequenced Drosophila genome suggested the presence of an additional enzyme with extensive homology to mammalian… Expand
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2001
2001
Disruption of Neuroendocrine Control of Luteinizing Hormone Secretion by Aroclor 1254 Involves Inhibition of Hypothalamic Tryptophan Hydroxylase Activity1
Abstract Mechanisms governing the effect of polychlorinated biphenyl (PCB) toxicity on hypothalamic serotonergic function and the… Expand
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Highly Cited
1998
Highly Cited
1998
The effects of methamphetamine on the production of free radicals and oxidative stress.
The effects of methamphetamine (METH) on pro-oxidant processes and on the production of reactive oxygen species were examined in… Expand
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1990
1990
Antagonism of the neurotoxicity due to a single administration of methylenedioxymethamphetamine.
The role of transmitter release in the serotonergic neurotoxicity of methylenedioxymethamphetamine (MDMA) was examined using… Expand
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Highly Cited
1987
Highly Cited
1987
Depression of rat brain tryptophan hydroxylase activity following the acute administration of methylenedioxymethamphetamine.
The psychotomimetic agent, methylenedioxymethamphetamine, produced a rapid, persistent and dose-dependent reduction in cortical… Expand
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Highly Cited
1987
Highly Cited
1987
Differences in the central serotonergic effects of Methylenedioxymethamphetamine (MDMA) in mice and rats
The effects of subcutaneous injection of 3,4-methylenedioxymethamphetamine (MDMA), a psychoactive amphetamine congener, on mouse… Expand
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1985
1985
Role of the dopamine uptake carrier in the neurochemical response to methamphetamine: effects of amfonelic acid.
Repeated administration of large doses of methamphetamine depresses both neostriatal tyrosine hydroxylase and tryptophan… Expand
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1976
1976
Histologic and enzymatic studies of the mesolimbic and mesostriatal serotonergic pathways
Selective lesions of the dorsal (B7), median (B8), or lateral (B9) raphe nuclei were made stereotaxically in male rats 4 weeks… Expand
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