FAQ

tryptophan 5-monooxygenase activity

Known as: tryptophan hydroxylase activity, tryptophan 5-hydroxylase activity, L-tryptophan,tetrahydrobiopterin:oxygen oxidoreductase (5-hydroxylating) 
Catalysis of the reaction: L-tryptophan + tetrahydrobiopterin + O2 = 5-hydroxy-L-tryptophan + 4-alpha-hydroxytetrahydrobiopterin + H2O. [EC:1.14.16.4… (More)
National Institutes of Health

Topic mentions per year

Topic mentions per year

1967-2015
051019672015

Papers overview

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2007
2007
Widespread endocrine disruption and reproductive impairment in an estuarine fish population exposed to seasonal hypoxia.
The long-term effects on marine fish populations of the recent increase worldwide in the incidence of coastal hypoxia are unknown… (More)
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1999
1999
Peroxynitrite inactivates tryptophan hydroxylase via sulfhydryl oxidation. Coincident nitration of enzyme tyrosyl residues has minimal impact on catalytic activity.
Tryptophan hydroxylase, the initial and rate-limiting enzyme in serotonin biosynthesis, is inactivated by peroxynitrite in a… (More)
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1992
1992
Lack of serotonin neurotoxicity after intraraphe microinjection of (+)-3,4-methylenedioxymethamphetamine (MDMA).
Systemic administration of 3,4-methylenedioxymethamphetamine (MDMA) produces depletions of serotonin (5-HT) and its primary… (More)
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1990
1990
Antagonism of the neurotoxicity due to a single administration of methylenedioxymethamphetamine.
The role of transmitter release in the serotonergic neurotoxicity of methylenedioxymethamphetamine (MDMA) was examined using… (More)
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1989
1989
In vitro reactivation of rat cortical tryptophan hydroxylase following in vivo inactivation by methylenedioxymethamphetamine.
The activity of tryptophan hydroxylase (EC 1.14.16.4) from rat brain was significantly decreased 1 h following a single systemic… (More)
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Highly Cited
1987
Highly Cited
1987
Depression of rat brain tryptophan hydroxylase activity following the acute administration of methylenedioxymethamphetamine.
The psychotomimetic agent, methylenedioxymethamphetamine, produced a rapid, persistent and dose-dependent reduction in cortical… (More)
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1987
1987
Differences in the central serotonergic effects of methylenedioxymethamphetamine (MDMA) in mice and rats.
The effects of subcutaneous injection of 3,4-methylenedioxymethamphetamine (MDMA), a psychoactive amphetamine congener, on mouse… (More)
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1976
1976
Influence of neonatal and adult hyperthyroidism on behavior and biosynthetic capacity for norepinephrine, dopamine and 5-hydroxytryptamine in rat brain.
In neonatal rats, administration of l-triiodothyronine (10 mug/100 g/day) for 30 days presented signs of hyperthyroidism which… (More)
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1976
1976
Histologic and enzymatic studies of the mesolimbic and mesostriatal serotonergic pathways.
Selective lesions of the dorsal (B7), median (B8), or lateral (B9) raphe nuclei were made stereotaxically in male rats 4 weeks… (More)
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1969
1969
Corticosterone regulation of tryptophan hydroxylase in midbrain of the rat.
The tryptophan hydroxylase activity in the rat midbrain decreases after adrenalectomy and is restored by treatment with… (More)
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