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tryptophan 5-monooxygenase activity

Known as: tryptophan hydroxylase activity, tryptophan 5-hydroxylase activity, L-tryptophan,tetrahydrobiopterin:oxygen oxidoreductase (5-hydroxylating) 
Catalysis of the reaction: L-tryptophan + tetrahydrobiopterin + O2 = 5-hydroxy-L-tryptophan + 4-alpha-hydroxytetrahydrobiopterin + H2O. [EC:1.14.16.4… Expand
National Institutes of Health

Papers overview

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Highly Cited
2007
Highly Cited
2007
The long-term effects on marine fish populations of the recent increase worldwide in the incidence of coastal hypoxia are unknown… Expand
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2005
2005
The brain neurotransmitter serotonin is involved in the regulation of aggressive behavior. The main factor determining the brain… Expand
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2005
2005
Annotation of the sequenced Drosophila genome suggested the presence of an additional enzyme with extensive homology to mammalian… Expand
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2001
2001
Abstract Mechanisms governing the effect of polychlorinated biphenyl (PCB) toxicity on hypothalamic serotonergic function and the… Expand
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Highly Cited
1998
Highly Cited
1998
The effects of methamphetamine (METH) on pro-oxidant processes and on the production of reactive oxygen species were examined in… Expand
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1990
1990
The role of transmitter release in the serotonergic neurotoxicity of methylenedioxymethamphetamine (MDMA) was examined using… Expand
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Highly Cited
1987
Highly Cited
1987
The psychotomimetic agent, methylenedioxymethamphetamine, produced a rapid, persistent and dose-dependent reduction in cortical… Expand
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Highly Cited
1987
Highly Cited
1987
The effects of subcutaneous injection of 3,4-methylenedioxymethamphetamine (MDMA), a psychoactive amphetamine congener, on mouse… Expand
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1985
1985
Repeated administration of large doses of methamphetamine depresses both neostriatal tyrosine hydroxylase and tryptophan… Expand
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1976
1976
Selective lesions of the dorsal (B7), median (B8), or lateral (B9) raphe nuclei were made stereotaxically in male rats 4 weeks… Expand
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