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tryptophan 5-monooxygenase activity

Known as: tryptophan hydroxylase activity, tryptophan 5-hydroxylase activity, L-tryptophan,tetrahydrobiopterin:oxygen oxidoreductase (5-hydroxylating) 
Catalysis of the reaction: L-tryptophan + tetrahydrobiopterin + O2 = 5-hydroxy-L-tryptophan + 4-alpha-hydroxytetrahydrobiopterin + H2O. [EC:1.14.16.4… 
National Institutes of Health

Papers overview

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Highly Cited
1999
Highly Cited
1999
Peroxynitrite Inactivates Tryptophan Hydroxylase via Sulfhydryl Oxidation
Tryptophan hydroxylase, the initial and rate-limiting enzyme in serotonin biosynthesis, is inactivated by peroxynitrite in a… 
Highly Cited
1990
Highly Cited
1990
Antagonism of the neurotoxicity due to a single administration of methylenedioxymethamphetamine.
Highly Cited
1989
Highly Cited
1989
Increase in the activity of tryptophan hydroxylase from cortex and midbrain of male Fischer 344 rats in response to acute or repeated sound stress
Highly Cited
1987
Highly Cited
1987
Differences in the central serotonergic effects of Methylenedioxymethamphetamine (MDMA) in mice and rats
Highly Cited
1983
Highly Cited
1983
Tyrosine hydroxylase activation in depolarized dopaminergic terminals—involvement of Ca2+ -dependent phosphorylation
Tyrosine hydroxylase (tyrosine 3-monoxygenase, EC 1.14.16.2, TH) catalyses the rate limiting step of catecholamine biosynthesis… 
Highly Cited
1977
Highly Cited
1977
Serotonergic innervation of the forebrain: Effect of lesions on serotonin and tryptophan hydroxylase levels
Highly Cited
1976
Highly Cited
1976
Histologic and enzymatic studies of the mesolimbic and mesostriatal serotonergic pathways
Highly Cited
1975
Highly Cited
1975
Long-term effects of p-chloroamphetamine and related drugs on central serotonergic mechanisms.
Earlier studies from our laboratory have demonstrated a marked reduction in the brain level of 5-hydroxytryptamine (5-HT) and in… 
Highly Cited
1974
Highly Cited
1974
Adrenalcortical influence on rat brain tryptophan hydroxylase activity.
Highly Cited
1971
Highly Cited
1971
Selective reduction of tryptophan hydroxylase activity in rat forebrain after midbrain raphe lesions.
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