Catecholamine Metabolism: A Contemporary View with Implications for Physiology and Medicine
- G. Eisenhofer, I. Kopin, D. Goldstein
- Biology, ChemistryPharmacological Reviews
- 1 September 2004
The large contribution of intraneuronal deamination to catecholamine turnover, and dependence of this on the vesicular-axoplasmic monoamine exchange process, helps explain how synthesis, release, metabolism, turnovers, and stores of catechlamines are regulated in a coordinated fashion during stress and in disease states.
The Biochemical Basis of Neuropharmacology
- I. Kopin
- MedicineThe Yale Journal of Biology and Medicine
- 1 October 1971
The monograph tells us that EP is the principle hormone which regulates erythropoiesis, and how it acts by causing a committed but undifferentiated cell to differentiate into an erythroblast, and may also have a role in causing maturation of ERYthroblasts.
A primate model of parkinsonism: selective destruction of dopaminergic neurons in the pars compacta of the substantia nigra by N-methyl-4-phenyl-1,2,3,6-tetrahydropyridine.
- R. Burns, C. Chiueh, S. Markey, M. Ebert, D. Jacobowitz, I. Kopin
- BiologyProceedings of the National Academy of Sciences…
- 1 July 1983
The N-methyl-4-phenyl-1,2,3,6-tetrahydropyridine-treated monkey provides a model that can be used to examine mechanisms and explore therapies of parkinsonism and the pathological and biochemical changes produced by NMPTP are similar to the well-established changes in patients with parkinsonistan.
Chronic parkinsonism secondary to intravenous injection of meperidine analogues
- G. Davis, Adrian C. Williams, I. Kopin
- Medicine, BiologyPsychiatry Research
- 1 December 1979
Sources and Significance of Plasma Levels of Catechols and Their Metabolites in Humans
- D. Goldstein, G. Eisenhofer, I. Kopin
- Biology, ChemistryJournal of Pharmacology and Experimental…
- 1 June 2003
Human plasma contains several catechols, including the catecholamines norepinephrine, epinephrine, and dopamine, their precursor, l-3,4-dihydroxyphenylalanine (l-DOPA), and their deaminated…
Catecholamine metabolism: basic aspects and clinical significance.
- I. Kopin
- MedicinePharmacological Reviews
- 1 December 1985
Dopamine Biosynthesis Is Selectively Abolished in Substantia Nigra/Ventral Tegmental Area but Not in Hypothalamic Neurons in Mice with Targeted Disruption of the Nurr1 Gene
- S. O. Castillo, J. Baffi, V. Nikodem
- BiologyMolecular and Cellular Neuroscience
- 1 May 1998
Dopamine was absent in the substantia nigra and ventral tegmental area of Nurr1-null mice, consistent with absent tyrosine hydroxylase (TH), L-aromatic amino acid decarboxylase, and other DA neuron markers, providing evidence for a new mechanism of DA depletion in vivo and suggesting a unique role for Nurr 1 in fetal development and/or postnatal survival.
The analgesic effects of R(+)-WIN 55,212–2 mesylate, a high affinity cannabinoid agonist, in a rat model of neuropathic pain
- U. Herzberg, E. Eliav, G. Bennett, I. Kopin
- Biology, MedicineNeuroscience Letters
- 17 January 1997
- J. Bureš, I. Kopin, B. McEwen, J. McGaugh, W. Montagna
- PsychologyAdvances in behavioral biology
Stress-Induced Norepinephrine Release in the Hypothalamic Paraventricular Nucleus and Pituitary-Adrenocortical and Sympathoadrenal Activity: In Vivo Microdialysis Studies
- K. Pacak, M. Palkovits, I. Kopin, D. Goldstein
- BiologyFrontiers in neuroendocrinology (Print)
- 1 April 1995
Exposure of animals to immobilization (IMMO) markedly and rapidly increases rates of synthesis, release, and metabolism of norepinephrine in all the brain areas mentioned above and supports previous suggestions that in the PVN NE stimulates release of corticotropin-releasing hormone (CRH).