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A description of the nicotine stimulus and tests of its generalization to amphetamine
- W. Chance, D. Murfin, G. Krynock, J. Rosecrans
- Psychology, Medicine
- 24 November 1977
The discriminative stimulus properties of nicotine were investigated under a variety of conditions in three separate experiments. In each of these experiments the subject's performance was assessed… Expand
Drug‐induced discrimination: A description of the paradigm and a review of its specific application to the study of hallucinogenic agents
Antagonism of the effects of the hallucinogen DOM and the purported 5-HT agonist quipazine by 5-HT2 antagonists.
Rats trained to discriminate 1.0 mg/kg of 1-(2,5-dimethoxy-4-methylphenyl)-2-aminopropane (DOM) from saline in a two-lever operant choice task were administered doses of mescaline, LSD,… Expand
Stimulus properties of drugs : ten years of progress
Disruption of Th1/Th2 cytokine balance by cocaine is mediated by corticosterone.
Cocaine has been shown to affect immune function through the release of corticosterone. Acute administration of both cocaine and corticosterone produces an enhancement of the T-dependent antibody… Expand
Studies on the time course and the effect of cholinergic and adrenergic receptor blockers on the stimulus effect of nicotine
This study investigated the stimulus property of nicotine in the rat. The primary objectives of the study were 1. to determine the time course of the nicotine stimulus and its relationship to brain… Expand
Discriminative stimulus properties of MDA analogs.
Rats trained to discriminate (+/-) 2,5-dimethoxy-4-methylphenylisopropylamine (DOM) (1.0 mg/kg) from saline, using a standard two-lever operant task, were challenged with various doses of… Expand
Pharmacological effects of epibatidine optical enantiomers
- M. I. Damaj, K. Creasy, A. Grove, J. Rosecrans, B. Martin
- Chemistry, Medicine
- Brain Research
- 21 November 1994
The pharmacology of synthetic D- and L-epibatidine, an alkaloid originally characterized from frog skin, were studied in different behavioral tests in mice and rats. The two enantiomers have potent… Expand
DOM-stimulus generalization to LSD and other hallucinogenic indolealkylamines.
- R. Glennon, R. Young, J. Jacyno, M. Slusher, J. Rosecrans
- Psychology, Medicine
- European journal of pharmacology
- 21 January 1983
Stimulus generalization studies were conducted using rats trained to discriminate 1.0 mg/kg of the phenalkylamine hallucinogen 1-(2,5-dimethoxy-4-methylphenyl)-2-aminopropane (DOM) from saline in a… Expand
Nicotine does not interact with the discriminative stimulus effects of clozapine in rats
The purpose of the present study was to assess the potential interaction between clozapine, an atypical antipsychotic recently approved for clinical use in the United States and nicotine. Male… Expand