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A Mammalian microRNA Expression Atlas Based on Small RNA Library Sequencing
TLDR
A relatively small set of miRNAs, many of which are ubiquitously expressed, account for most of the differences in miRNA profiles between cell lineages and tissues. Expand
Stressor specificity of central neuroendocrine responses: implications for stress-related disorders.
TLDR
This review focuses mainly on the similarities and differences between the neuroendocrine responses (especially the sympathoadrenal and the sympathoneuronal systems and the hypothalamo-pituitary-adrenocortical axis) among various stressors and a strategy for testing Selye's doctrine of nonspecificity. Expand
Catecholaminergic systems in stress: structural and molecular genetic approaches.
TLDR
Data summarized here indicate that catecholaminergic systems are activated in different ways following exposure to distinct stressful stimuli. Expand
Physiological role of a novel neuropeptide, apelin, and its receptor in the rat brain
TLDR
Results suggest that neuronal apelin plays an important role in the central control of body fluid homeostasis through its role in internalization and the pharmacological profile of the apelin receptor. Expand
Axonal changes in chronic demyelinated cervical spinal cord plaques.
TLDR
The results on the cervical cord combined with other observations support the concept of slow axonal degeneration rather than acute damage as a cause of chronic disability in multiple sclerosis. Expand
Expression of Angiotensin Type-1 (AT1) and Type-2 (AT2) Receptor mRNAs in the Adult Rat Brain: A Functional Neuroanatomical Review
TLDR
In several functional entities of the brain, such as the preoptic region, the hypothalamus, the olivocerebellary system, and the brainstem baroreflex arc, the colocalization of receptor mRNA, binding sites, and angiotensin immunoreactive nerve terminals suggests local synthesis and expression of angiotENSin II receptors. Expand
Dopamine Biosynthesis Is Selectively Abolished in Substantia Nigra/Ventral Tegmental Area but Not in Hypothalamic Neurons in Mice with Targeted Disruption of the Nurr1 Gene
TLDR
Dopamine was absent in the substantia nigra and ventral tegmental area of Nurr1-null mice, consistent with absent tyrosine hydroxylase (TH), L-aromatic amino acid decarboxylase, and other DA neuron markers, providing evidence for a new mechanism of DA depletion in vivo and suggesting a unique role for Nurr 1 in fetal development and/or postnatal survival. Expand
Isolation and measurement of the endogenous cannabinoid receptor agonist, anandamide, in brain and peripheral tissues of human and rat
TLDR
The distribution of anandamide in human brain and spleen supports its potential role as an endogenous agonist in central and peripheral tissues and suggests that it is metabolized in tissues where it is synthesized, and that its action is probably not hormonal in nature. Expand
The LIM-homeobox gene Lhx8 is required for the development of many cholinergic neurons in the mouse forebrain
TLDR
Genetic evidence supporting an important role for Lhx8 in development of cholinergic neurons in the forebrain is provided, as indicated by a presence of cells expressing a truncated Lx8 mRNA and mRNA of the homeobox gene Gbx1. Expand
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