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Neurogenesis in the adult human hippocampus
The genesis of new cells, including neurons, in the adult human brain has not yet been demonstrated. This study was undertaken to investigate whether neurogenesis occurs in the adult human brain, inExpand
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Mechanisms and Functional Implications of Adult Neurogenesis
The generation of new neurons is sustained throughout adulthood in the mammalian brain due to the proliferation and differentiation of adult neural stem cells. In this review, we discuss the factorsExpand
  • 2,663
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Running increases cell proliferation and neurogenesis in the adult mouse dentate gyrus
Exposure to an enriched environment increases neurogenesis in the dentate gyrus of adult rodents. Environmental enrichment, however, typically consists of many components, such as expanded learningExpand
  • 3,473
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In Vivo Gene Delivery and Stable Transduction of Nondividing Cells by a Lentiviral Vector
A retroviral vector system based on the human immunodeficiency virus (HIV) was developed that, in contrast to a murine leukemia virus-based counterpart, transduced heterologous sequences into HeLaExpand
  • 4,301
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Distinct Morphological Stages of Dentate Granule Neuron Maturation in the Adult Mouse Hippocampus
Adult neurogenesis in the dentate gyrus may contribute to hippocampus-dependent functions, yet little is known about when and how newborn neurons are functional because of limited information aboutExpand
  • 1,076
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Running enhances neurogenesis, learning, and long-term potentiation in mice.
Running increases neurogenesis in the dentate gyrus of the hippocampus, a brain structure that is important for memory function. Consequently, spatial learning and long-term potentiation (LTP) wereExpand
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More hippocampal neurons in adult mice living in an enriched environment
Neurogenesis occurs in the dentate gyrus of the hippocampus throughout the life of a rodent1–4, but the function of these new neurons and the mechanisms that regulate their birth are unknown. Here weExpand
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Mechanisms Underlying Inflammation in Neurodegeneration
Inflammation is associated with many neurodegenerative diseases, including Alzheimer's disease, Parkinson's disease, amyotrophic lateral sclerosis, and multiple sclerosis. In this Review, we discussExpand
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Mammalian neural stem cells.
  • F. Gage
  • Medicine, Biology
  • Science
  • 25 February 2000
Neural stem cells exist not only in the developing mammalian nervous system but also in the adult nervous system of all mammalian organisms, including humans. Neural stem cells can also be derivedExpand
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Neurogenesis in the dentate gyrus of the adult rat: age-related decrease of neuronal progenitor proliferation
The hippocampus is one of the few areas of the rodent brain that continues to produce neurons postnatally. Neurogenesis reportedly persists in rats up to 11 months of age. Using bromodeoxyuridineExpand
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