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Neurogenesis in the adult human hippocampus
It is demonstrated that new neurons, as defined by these markers, are generated from dividing progenitor cells in the dentate gyrus of adult humans, indicating that the human hippocampus retains its ability to generate neurons throughout life. Expand
Mechanisms and Functional Implications of Adult Neurogenesis
The factors that regulate proliferation and fate determination of adult neural stem cells are discussed and the potential significance of adult neurogenesis in memory, depression, and neurodegenerative disorders such as Alzheimer's and Parkinson's disease is addressed. Expand
Running increases cell proliferation and neurogenesis in the adult mouse dentate gyrus
It is demonstrated that voluntary exercise is sufficient for enhanced neurogenesis in the adult mouse dentate gyrus, in amounts similar to enrichment conditions. Expand
Distinct Morphological Stages of Dentate Granule Neuron Maturation in the Adult Mouse Hippocampus
The study reveals the key morphological transitions of newborn granule neurons during their course of maturation and shows that the morphological maturation is differentially affected by age and experience, as shown by comparisons between adult and postnatal brains and between housing conditions. Expand
More hippocampal neurons in adult mice living in an enriched environment
It is shown that significantly more new neurons exist in the dentate gyrus of mice exposed to an enriched environment compared with littermates housed in standard cages, and that the enriched mice have a larger hippocampal granule cell layer and 15 per cent moregranule cell neurons in the Dentate Gyrus. Expand
In Vivo Gene Delivery and Stable Transduction of Nondividing Cells by a Lentiviral Vector
The ability of HIV-based viral vectors to deliver genes in vivo into nondividing cells could increase the applicability of retroviral vectors in human gene therapy. Expand
Mechanisms Underlying Inflammation in Neurodegeneration
There is evidence for a remarkable convergence in the mechanisms responsible for the sensing, transduction, and amplification of inflammatory processes that result in the production of neurotoxic mediators in neurodegenerative diseases. Expand
New neurons and new memories: how does adult hippocampal neurogenesis affect learning and memory?
The integration of adult-born neurons into the circuitry of the adult hippocampus suggests an important role for adult hippocampal neurogenesis in learning and memory, but its specific function inExpand
Reactive astrocytes: cellular and molecular cues to biological function
Reactive astrocytes should be considered a key element, like neurons, of a dynamic environment, thus forming with neurons a functional unit involved in homeostasis, plasticity and neurotransmission. Expand
Mammalian neural stem cells.
  • F. Gage
  • Biology, Medicine
  • Science
  • 25 February 2000
Before the full potential of neural stem cells can be realized, the authors need to learn what controls their proliferation, as well as the various pathways of differentiation available to their daughter cells. Expand