• Publications
  • Influence
Protective and damaging effects of stress mediators.
  • B. McEwen
  • Medicine
  • The New England journal of medicine
  • 15 January 1998
TLDR
The long-term effect of the physiologic response to stress is reviewed, which I refer to as allostatic load, which is the ability to achieve stability through change. Expand
The concept of allostasis in biology and biomedicine
TLDR
The concept of allostasis is discussed, maintaining stability through change, as a fundamental process through which organisms actively adjust to both predictable and unpredictable events, using the balance between energy input and expenditure as the basis for applying the concept. Expand
Effects of stress throughout the lifespan on the brain, behaviour and cognition
TLDR
In this Review a model is developed to explain why different disorders emerge in individuals exposed to stress at different times in their lives. Expand
Allostatic load biomarkers of chronic stress and impact on health and cognition
TLDR
This article reviews theoretical and empirical work using the allostatic load model vis-à-vis the effects of chronic stress on physical and mental health and proposes policies for promoting successful aging. Expand
Central effects of stress hormones in health and disease: Understanding the protective and damaging effects of stress and stress mediators.
  • B. McEwen
  • Psychology, Medicine
  • European journal of pharmacology
  • 7 April 2008
TLDR
The adaptive plasticity of chronic stress involves many mediators, including glucocorticoids, excitatory amino acids, endogenous factors such as brain neurotrophic factor (BDNF), polysialated neural cell adhesion molecule (PSA-NCAM) and tissue plasminogen activator (tPA), which leads to a different way of regarding more holistic manipulations. Expand
Stress and the individual. Mechanisms leading to disease.
TLDR
A new formulation of the relationship between stress and the processes leading to disease is presented, emphasizing the cascading relationships between environmental factors and genetic predispositions that lead to large individual differences in susceptibility to stress and, in some cases, to disease. Expand
The neurobiology of stress: from serendipity to clinical relevance 1 1 Published on the World Wide Web on 22 November 2000.
  • B. McEwen
  • Biology, Psychology
  • Brain Research
  • 1 December 2000
TLDR
Comparison of the effects of experimenter-applied stressors and psychosocial stressors show that what animals do to each other is often more potent than what experimenters do to them, and yet the brain is resilient and capable of adaptive plasticity. Expand
Stress and hippocampal plasticity.
  • B. McEwen
  • Psychology, Medicine
  • Annual review of neuroscience
  • 1999
TLDR
The hippocampus is a target of stress hormones, and it is an especially plastic and vulnerable region of the brain that undergoes a selective atrophy in a number of disorders, accompanied by deficits in declarative episodic, spatial, and contextual memory performance. Expand
Astrocytes Give Rise to New Neurons in the Adult Mammalian Hippocampus
TLDR
It is shown that SGL cells, which express glial fibrillary acidic protein and have the characteristics of astrocytes, divide and generate new neurons under normal conditions or after the chemical removal of actively dividing cells. Expand
Allostasis and Allostatic Load: Implications for Neuropsychopharmacology
  • B. McEwen
  • Psychology, Medicine
  • Neuropsychopharmacology
  • 1 February 2000
TLDR
In anxiety disorders, depressive illness, hostile and aggressive states, substance abuse, and post-traumatic stress disorder, allostatic load takes the form of chemical imbalances as well as perturbations in the diurnal rhythm, and in some cases, atrophy of brain structures. Expand
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